SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a3t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 4a3t DNA MISMATCH REPAIR
PROTEIN HSM3
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 175
LEU A 178
PHE A 174
PHE A 217
LEU A 200
 None
 1.07A 1ao8A-4a3tA:
undetectable		 1ao8A-4a3tA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 4a3t DNA MISMATCH REPAIR
PROTEIN HSM3
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 138
ASN A 133
LEU A 101
LEU A 105
 None
 1.04A 1e7cA-4a3tA:
undetectable		 1e7cA-4a3tA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 4a3t DNA MISMATCH REPAIR
PROTEIN HSM3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 415
TYR A 384
GLY A 417
VAL A 430
LEU A 427
 None
 1.06A 1vptA-4a3tA:
undetectable		 1vptA-4a3tA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 4a3t DNA MISMATCH REPAIR
PROTEIN HSM3
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 135
LEU A 160
ILE A 156
ALA A 159
LEU A 105
 None
 1.21A 3a50A-4a3tA:
undetectable		 3a50A-4a3tA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 4a3t DNA MISMATCH REPAIR
PROTEIN HSM3
(Saccharomyces
cerevisiae) 		3 / 3 CYH A 218
PHE A 217
PHE A 244
 None
 1.01A 3cr5X-4a3tA:
undetectable		 3cr5X-4a3tA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4a3t DNA MISMATCH REPAIR
PROTEIN HSM3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 380
VAL A 411
SER A 414
VAL A 349
LEU A 357
 None
 1.42A 3vt3A-4a3tA:
undetectable		 3vt3A-4a3tA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4a3t DNA MISMATCH REPAIR
PROTEIN HSM3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 380
VAL A 411
SER A 414
VAL A 349
LEU A 357
 None
 1.42A 3vt7A-4a3tA:
undetectable		 3vt7A-4a3tA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 4a3t DNA MISMATCH REPAIR
PROTEIN HSM3
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 120
LEU A 173
ASP A 166
GLY A 127
PHE A 129
 None
 1.47A 4foxF-4a3tA:
undetectable		 4foxF-4a3tA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4a3t DNA MISMATCH REPAIR
PROTEIN HSM3
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 347
ILE A 378
VAL A 379
THR A 400
VAL A 390
 None
 1.12A 4r20B-4a3tA:
undetectable		 4r20B-4a3tA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4a3t DNA MISMATCH REPAIR
PROTEIN HSM3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 291
LEU A 314
ALA A 268
LEU A 264
ILE A 298
 None
 1.17A 4x1yB-4a3tA:
undetectable		 4x1yB-4a3tA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4a3t DNA MISMATCH REPAIR
PROTEIN HSM3
(Saccharomyces
cerevisiae) 		4 / 6 ILE A  29
VAL A  79
PHE A  61
THR A  57
 None
 1.13A 4xe5A-4a3tA:
undetectable		 4xe5A-4a3tA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 4a3t DNA MISMATCH REPAIR
PROTEIN HSM3
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 247
LYS A 253
ASN A 250
 None
 0.89A 4y1dA-4a3tA:
undetectable
4y1dD-4a3tA:
undetectable		 4y1dA-4a3tA:
16.49
4y1dD-4a3tA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 4a3t DNA MISMATCH REPAIR
PROTEIN HSM3
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  29
THR A  57
ILE A  58
LEU A  13
 None
 0.68A 5fukA-4a3tA:
undetectable
5fukB-4a3tA:
undetectable		 5fukA-4a3tA:
19.19
5fukB-4a3tA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4a3t DNA MISMATCH REPAIR
PROTEIN HSM3
(Saccharomyces
cerevisiae) 		3 / 3 LYS A  72
ASP A  74
ARG A  34
 None
 1.01A 5jwaA-4a3tA:
undetectable
5jwaH-4a3tA:
undetectable		 5jwaA-4a3tA:
23.56
5jwaH-4a3tA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4a3t DNA MISMATCH REPAIR
PROTEIN HSM3
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 150
GLU A 157
ASP A 198
GLU A 236
 None
 1.50A 6mn5A-4a3tA:
undetectable		 6mn5A-4a3tA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4a3t DNA MISMATCH REPAIR
PROTEIN HSM3
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 150
GLU A 157
ASP A 198
GLU A 236
 None
 1.40A 6mn5C-4a3tA:
undetectable		 6mn5C-4a3tA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4a3t DNA MISMATCH REPAIR
PROTEIN HSM3
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 150
GLU A 157
ASP A 198
GLU A 236
 None
 1.44A 6mn5D-4a3tA:
undetectable		 6mn5D-4a3tA:
10.11