SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a3u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		5 / 12 ILE A 216
ALA A 157
SER A  54
ILE A  53
PRO A  23
 None
None
None
ACT  A1358 (-4.7A)
FMN  A1357 (-4.2A)
 1.16A 1dlsA-4a3uA:
undetectable		 1dlsA-4a3uA:
19.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H60_A_STRA500_1
(PENTAERYTHRITOL
TETRANITRATE
REDUCTASE)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		5 / 9 THR A  25
HIS A 172
TYR A 177
GLN A 232
TYR A 343
 NCA  A1359 ( 3.2A)
FMN  A1357 ( 3.6A)
NCA  A1359 (-4.5A)
None
FMN  A1357 ( 4.2A)
 0.52A 1h60A-4a3uA:
54.7		 1h60A-4a3uA:
41.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		5 / 11 LEU A 204
PHE A 182
LEU A 151
LEU A 142
LEU A 150
 None
 1.32A 1mx1B-4a3uA:
3.5		 1mx1B-4a3uA:
22.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ABA_A_STRA1500_1
(PENTAERYTHRITOL
TETRANITRATE
REDUCTASE)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		5 / 9 THR A  25
HIS A 172
TYR A 177
GLN A 232
TYR A 343
 NCA  A1359 ( 3.2A)
FMN  A1357 ( 3.6A)
NCA  A1359 (-4.5A)
None
FMN  A1357 ( 4.2A)
 0.57A 2abaA-4a3uA:
54.8		 2abaA-4a3uA:
41.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		5 / 12 LEU A 225
ILE A 231
ILE A 281
SER A 278
ALA A 246
 None
 1.13A 2ejtA-4a3uA:
undetectable		 2ejtA-4a3uA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		4 / 5 GLY A 315
TRP A 342
ARG A 316
LEU A  24
 FMN  A1357 (-3.2A)
FMN  A1357 (-3.8A)
FMN  A1357 (-3.8A)
FMN  A1357 (-4.5A)
 1.35A 2j2pD-4a3uA:
undetectable
2j2pF-4a3uA:
undetectable		 2j2pD-4a3uA:
19.27
2j2pF-4a3uA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		4 / 8 SER A 186
THR A 187
PRO A 118
LEU A 178
 None
 1.14A 2v0zO-4a3uA:
undetectable		 2v0zO-4a3uA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		4 / 7 GLU A  55
ILE A  95
ALA A 311
ILE A   8
 None
 0.73A 2xkwA-4a3uA:
undetectable		 2xkwA-4a3uA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		5 / 12 ALA A 300
ARG A 316
PRO A  23
LEU A 324
THR A 299
 None
FMN  A1357 (-3.8A)
FMN  A1357 (-4.2A)
None
None
 1.01A 3nrrA-4a3uA:
undetectable		 3nrrA-4a3uA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		5 / 12 ALA A 300
ARG A 316
PRO A  23
LEU A 324
THR A 299
 None
FMN  A1357 (-3.8A)
FMN  A1357 (-4.2A)
None
None
 1.04A 3nrrB-4a3uA:
undetectable		 3nrrB-4a3uA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		3 / 3 THR A 335
ASP A 323
GLU A 330
 None
 0.84A 3qowA-4a3uA:
undetectable		 3qowA-4a3uA:
22.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UPW_A_NCAA412_0
(OLD YELLOW ENZYME
2.6 (OYE2.6), NADPH
DEHYDROGENASE)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		5 / 9 THR A  25
ALA A  56
HIS A 172
TYR A 177
TYR A 343
 NCA  A1359 ( 3.2A)
FMN  A1357 (-3.1A)
FMN  A1357 ( 3.6A)
NCA  A1359 (-4.5A)
FMN  A1357 ( 4.2A)
 0.34A 3upwA-4a3uA:
47.0		 3upwA-4a3uA:
33.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		4 / 6 ASN A 175
GLY A 176
ASP A 180
ILE A 183
 NCA  A1359 ( 3.3A)
None
None
None
 0.94A 3w9tF-4a3uA:
undetectable		 3w9tF-4a3uA:
21.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		5 / 9 ALA A  22
PRO A  23
GLN A  98
ARG A 224
ASN A 292
 FMN  A1357 (-3.6A)
FMN  A1357 (-4.2A)
FMN  A1357 (-3.0A)
FMN  A1357 ( 3.0A)
FMN  A1357 (-3.1A)
 1.33A 4a3uA-4a3uA:
69.6		 4a3uA-4a3uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		9 / 9 ALA A  22
PRO A  23
ILE A  53
GLN A 170
ARG A 224
GLY A 259
VAL A 290
ASN A 292
SER A 313
 FMN  A1357 (-3.6A)
FMN  A1357 (-4.2A)
ACT  A1358 (-4.7A)
ACT  A1358 (-3.3A)
FMN  A1357 ( 3.0A)
ACT  A1358 (-3.6A)
ACT  A1358 ( 4.8A)
FMN  A1357 (-3.1A)
ACT  A1358 (-2.4A)
 0.01A 4a3uA-4a3uA:
69.6		 4a3uA-4a3uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		7 / 7 THR A  25
TRP A  66
TRP A 100
HIS A 172
ASN A 175
TYR A 177
TYR A 343
 NCA  A1359 ( 3.2A)
NCA  A1359 (-4.7A)
None
FMN  A1357 ( 3.6A)
NCA  A1359 ( 3.3A)
NCA  A1359 (-4.5A)
FMN  A1357 ( 4.2A)
 0.01A 4a3uA-4a3uA:
69.6		 4a3uA-4a3uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		7 / 7 PRO A  23
ILE A  53
GLN A 170
ARG A 224
GLY A 259
VAL A 290
SER A 313
 FMN  A1357 (-4.2A)
ACT  A1358 (-4.7A)
ACT  A1358 (-3.3A)
FMN  A1357 ( 3.0A)
ACT  A1358 (-3.6A)
ACT  A1358 ( 4.8A)
ACT  A1358 (-2.4A)
 0.20A 4a3uB-4a3uA:
65.8		 4a3uB-4a3uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		7 / 7 THR A  25
TRP A  66
TRP A 100
HIS A 172
ASN A 175
TYR A 177
TYR A 343
 NCA  A1359 ( 3.2A)
NCA  A1359 (-4.7A)
None
FMN  A1357 ( 3.6A)
NCA  A1359 ( 3.3A)
NCA  A1359 (-4.5A)
FMN  A1357 ( 4.2A)
 0.17A 4a3uB-4a3uA:
65.8		 4a3uB-4a3uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		5 / 7 THR A  25
TRP A 100
HIS A 172
ASN A 175
TYR A 177
 NCA  A1359 ( 3.2A)
None
FMN  A1357 ( 3.6A)
NCA  A1359 ( 3.3A)
NCA  A1359 (-4.5A)
 0.28A 4awuA-4a3uA:
56.0		 4awuA-4a3uA:
43.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		4 / 6 THR A  25
HIS A 172
TYR A 177
TYR A 343
 NCA  A1359 ( 3.2A)
FMN  A1357 ( 3.6A)
NCA  A1359 (-4.5A)
FMN  A1357 ( 4.2A)
 0.29A 4df2A-4a3uA:
47.0		 4df2A-4a3uA:
33.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		4 / 6 GLY A  65
PRO A  67
GLY A  27
TYR A  68
 None
 0.83A 4dxuA-4a3uA:
undetectable		 4dxuA-4a3uA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		5 / 12 ILE A 216
ALA A 157
SER A  54
ILE A  53
PRO A  23
 None
None
None
ACT  A1358 (-4.7A)
FMN  A1357 (-4.2A)
 1.22A 4gh8B-4a3uA:
undetectable		 4gh8B-4a3uA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		3 / 3 LEU A 150
ASP A 153
TYR A 154
 None
 0.56A 4qc6B-4a3uA:
undetectable		 4qc6B-4a3uA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1007_1
(SERUM ALBUMIN)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		5 / 9 LEU A 205
LEU A 253
ILE A 255
SER A 251
ALA A 247
 None
 1.22A 4z69A-4a3uA:
undetectable		 4z69A-4a3uA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		3 / 3 THR A 335
ASP A 323
GLU A 330
 None
 0.81A 5fa8A-4a3uA:
undetectable		 5fa8A-4a3uA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		3 / 3 GLU A  41
TYR A  42
ARG A  46
 None
 0.77A 5uunA-4a3uA:
undetectable		 5uunA-4a3uA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		3 / 3 GLU A  41
TYR A  42
ARG A  46
 None
 0.83A 5uunB-4a3uA:
undetectable		 5uunB-4a3uA:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		6 / 8 THR A  25
TRP A 100
HIS A 172
ASN A 175
TYR A 177
TYR A 343
 NCA  A1359 ( 3.2A)
None
FMN  A1357 ( 3.6A)
NCA  A1359 ( 3.3A)
NCA  A1359 (-4.5A)
FMN  A1357 ( 4.2A)
 0.35A 5v4vA-4a3uA:
48.9		 5v4vA-4a3uA:
36.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		6 / 8 THR A  25
TRP A 100
HIS A 172
ASN A 175
TYR A 177
TYR A 343
 NCA  A1359 ( 3.2A)
None
FMN  A1357 ( 3.6A)
NCA  A1359 ( 3.3A)
NCA  A1359 (-4.5A)
FMN  A1357 ( 4.2A)
 0.34A 5v4vB-4a3uA:
49.0		 5v4vB-4a3uA:
36.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		3 / 3 THR A 234
THR A 187
ARG A 104
 None
 0.91A 5wm2A-4a3uA:
2.3		 5wm2A-4a3uA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		4 / 5 GLN A 170
THR A  85
HIS A  89
LEU A  51
 ACT  A1358 (-3.3A)
None
NA  A1360 (-3.7A)
None
 1.37A 6aphA-4a3uA:
undetectable		 6aphA-4a3uA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		5 / 9 HIS A 238
ASP A 236
LEU A 204
ARG A 184
ASP A 180
 None
 1.09A 6c2mB-4a3uA:
undetectable		 6c2mB-4a3uA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Zymomonas
mobilis) 		5 / 9 VAL A 242
ASP A 236
LEU A 204
ARG A 184
ASP A 180
 None
 1.00A 6c2mB-4a3uA:
undetectable		 6c2mB-4a3uA:
14.18