SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a3x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 4a3x EPA1P
([Candida]
glabrata) 		4 / 8 ALA A 163
ASP A 165
ILE A 109
VAL A 169
 None
LAT  A1269 ( 2.5A)
None
None
 0.72A 3nu9A-4a3xA:
undetectable		 3nu9A-4a3xA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4a3x EPA1P
([Candida]
glabrata) 		5 / 11 LEU A 207
PHE A 248
ILE A 219
VAL A 169
LEU A 221
 None
 0.96A 3w67A-4a3xA:
undetectable		 3w67A-4a3xA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4a3x EPA1P
([Candida]
glabrata) 		5 / 12 LEU A 207
PHE A 248
ILE A 219
VAL A 169
LEU A 221
 None
 1.04A 3w67B-4a3xA:
undetectable		 3w67B-4a3xA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4a3x EPA1P
([Candida]
glabrata) 		5 / 12 LEU A 207
PHE A 248
ILE A 219
VAL A 169
ILE A 109
 None
 0.90A 3w67D-4a3xA:
undetectable		 3w67D-4a3xA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4a3x EPA1P
([Candida]
glabrata) 		5 / 12 LEU A 207
PHE A 248
VAL A 169
LEU A 221
ILE A 109
 None
 0.88A 3w67D-4a3xA:
undetectable		 3w67D-4a3xA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4a3x EPA1P
([Candida]
glabrata) 		5 / 12 LEU A 207
PHE A 248
ILE A 219
VAL A 169
LEU A 221
 None
 0.84A 3w68A-4a3xA:
undetectable		 3w68A-4a3xA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4a3x EPA1P
([Candida]
glabrata) 		5 / 12 LEU A 207
PHE A 248
ILE A 219
VAL A 169
LEU A 221
 None
 0.86A 3w68D-4a3xA:
undetectable		 3w68D-4a3xA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 4a3x EPA1P
([Candida]
glabrata) 		5 / 12 LEU A 207
PHE A 234
PHE A 252
VAL A 169
PHE A 248
 None
 1.40A 4c9wA-4a3xA:
undetectable		 4c9wA-4a3xA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4a3x EPA1P
([Candida]
glabrata) 		4 / 7 PHE A 111
MET A 138
THR A 137
LEU A 136
 None
 0.84A 5b1bN-4a3xA:
undetectable
5b1bW-4a3xA:
undetectable		 5b1bN-4a3xA:
17.93
5b1bW-4a3xA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4a3x EPA1P
([Candida]
glabrata) 		4 / 7 PHE A 111
MET A 138
THR A 137
LEU A 136
 None
 0.85A 5b3sN-4a3xA:
undetectable
5b3sW-4a3xA:
undetectable		 5b3sN-4a3xA:
17.93
5b3sW-4a3xA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4a3x EPA1P
([Candida]
glabrata) 		4 / 7 PHE A 111
MET A 138
THR A 137
LEU A 136
 None
 0.84A 5iy5N-4a3xA:
undetectable
5iy5W-4a3xA:
undetectable		 5iy5N-4a3xA:
17.93
5iy5W-4a3xA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4a3x EPA1P
([Candida]
glabrata) 		5 / 12 PHE A 248
ILE A 219
VAL A 169
LEU A 221
ILE A 109
 None
 0.80A 5mueA-4a3xA:
undetectable		 5mueA-4a3xA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 4a3x EPA1P
([Candida]
glabrata) 		5 / 12 GLY A 172
ALA A 173
ASP A 178
PRO A  52
SER A  51
 None
 0.91A 5t2zA-4a3xA:
undetectable		 5t2zA-4a3xA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4a3x EPA1P
([Candida]
glabrata) 		4 / 7 ASP A 257
ARG A 182
TYR A 148
GLU A  64
 None
 1.36A 6mn5E-4a3xA:
undetectable		 6mn5E-4a3xA:
16.91