SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a45'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 4a45 ALPHA-N-ACETYLGLUCOS
AMINIDASE FAMILY
PROTEIN
(Clostridium
perfringens) 		5 / 12 HIS A1392
ALA A1484
GLY A1429
LEU A1401
PRO A1402
 NGA  A2494 (-3.6A)
None
None
None
None
 1.14A 1mjqC-4a45A:
undetectable
1mjqD-4a45A:
undetectable		 1mjqC-4a45A:
18.12
1mjqD-4a45A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 4a45 ALPHA-N-ACETYLGLUCOS
AMINIDASE FAMILY
PROTEIN
(Clostridium
perfringens) 		5 / 12 HIS A1392
ALA A1484
GLY A1429
LEU A1401
PRO A1402
 NGA  A2494 (-3.6A)
None
None
None
None
 1.15A 1mjqI-4a45A:
undetectable
1mjqJ-4a45A:
undetectable		 1mjqI-4a45A:
18.12
1mjqJ-4a45A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 4a45 ALPHA-N-ACETYLGLUCOS
AMINIDASE FAMILY
PROTEIN
(Clostridium
perfringens) 		4 / 8 SER A1368
ALA A1379
ALA A1486
ARG A1423
 None
None
None
NGA  A2494 (-2.6A)
 0.72A 2bxmA-4a45A:
undetectable		 2bxmA-4a45A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 4a45 ALPHA-N-ACETYLGLUCOS
AMINIDASE FAMILY
PROTEIN
(Clostridium
perfringens) 		5 / 12 VAL A1472
LEU A1436
PHE A1464
ALA A1493
PHE A1492
 None
 1.18A 2jj8C-4a45A:
undetectable		 2jj8C-4a45A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4a45 ALPHA-N-ACETYLGLUCOS
AMINIDASE FAMILY
PROTEIN
(Clostridium
perfringens) 		4 / 6 ASN A1430
TYR A1395
GLU A1376
ILE A1390
 None
NGA  A2494 (-3.3A)
NGA  A2494 (-2.7A)
None
 0.92A 3q5sA-4a45A:
undetectable		 3q5sA-4a45A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 4a45 ALPHA-N-ACETYLGLUCOS
AMINIDASE FAMILY
PROTEIN
(Clostridium
perfringens) 		4 / 7 ILE A1431
ALA A1476
VAL A1475
ALA A1486
 None
 0.76A 4g77A-4a45A:
undetectable		 4g77A-4a45A:
18.35