SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a4k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A25_A_SAMA279_1 (UNCHARACTERIZED PROTEIN PH0793)	4a4k	ANTIVIRAL HELICASE SKI2 (Saccharomyces cerevisiae)	3 / 3	MET A 875 GLU A 981 ASP A 909	None	0.76A	3a25A-4a4kA: undetectable	3a25A-4a4kA: 25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JUS_B_ECNB602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	4a4k	ANTIVIRAL HELICASE SKI2 (Saccharomyces cerevisiae)	5 / 9	LEU A 885 THR A 882 TYR A 878 ALA A 906 THR A 984	None	1.47A	3jusB-4a4kA: undetectable	3jusB-4a4kA: 20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NBQ_A_URFA400_1 (URIDINE PHOSPHORYLASE 1)	4a4k	ANTIVIRAL HELICASE SKI2 (Saccharomyces cerevisiae)	5 / 9	THR A 935 GLY A 917 LEU A 916 LEU A 904 ILE A1013	None	1.44A	3nbqA-4a4kA: undetectable	3nbqA-4a4kA: 23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NBQ_D_URFD400_1 (URIDINE PHOSPHORYLASE 1)	4a4k	ANTIVIRAL HELICASE SKI2 (Saccharomyces cerevisiae)	5 / 9	THR A 935 GLY A 917 LEU A 916 LEU A 904 ILE A1013	None	1.44A	3nbqD-4a4kA: undetectable	3nbqD-4a4kA: 23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MUE_A_VIVA302_0 (ALPHA-TOCOPHEROL TRANSFER PROTEIN)	4a4k	ANTIVIRAL HELICASE SKI2 (Saccharomyces cerevisiae)	5 / 12	ILE A1035 ILE A 983 LEU A 899 VAL A 922 ILE A 895	None	0.95A	5mueA-4a4kA: undetectable	5mueA-4a4kA: 24.46

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3A25_A_SAMA279_1","UNCHARACTERIZED PROTEIN PH0793","4a4k","ANTIVIRAL HELICASE SKI2","Saccharomyces cerevisiae",3,"MET A 875;GLU A 981;ASP A 909","None","0.76A","3a25A-4a4kA:undetectable","3a25A-4a4kA:25.62"],["3JUS_B_ECNB602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","4a4k","ANTIVIRAL HELICASE SKI2","Saccharomyces cerevisiae",5,"LEU A 885;THR A 882;TYR A 878;ALA A 906;THR A 984","None","1.47A","3jusB-4a4kA:undetectable","3jusB-4a4kA:20.51"],["3NBQ_A_URFA400_1","URIDINE PHOSPHORYLASE 1","4a4k","ANTIVIRAL HELICASE SKI2","Saccharomyces cerevisiae",5,"THR A 935;GLY A 917;LEU A 916;LEU A 904;ILE A1013","None","1.44A","3nbqA-4a4kA:undetectable","3nbqA-4a4kA:23.78"],["3NBQ_D_URFD400_1","URIDINE PHOSPHORYLASE 1","4a4k","ANTIVIRAL HELICASE SKI2","Saccharomyces cerevisiae",5,"THR A 935;GLY A 917;LEU A 916;LEU A 904;ILE A1013","None","1.44A","3nbqD-4a4kA:undetectable","3nbqD-4a4kA:23.78"],["5MUE_A_VIVA302_0","ALPHA-TOCOPHEROL TRANSFER PROTEIN","4a4k","ANTIVIRAL HELICASE SKI2","Saccharomyces cerevisiae",5,"ILE A1035;ILE A 983;LEU A 899;VAL A 922;ILE A 895","None","0.95A","5mueA-4a4kA:undetectable","5mueA-4a4kA:24.46"]]