SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a4l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 6 LEU A 314
ILE A 316
GLU A 186
ASP A 187
 None
 1.19A 1ditH-4a4lA:
undetectable
1ditP-4a4lA:
undetectable		 1ditH-4a4lA:
19.94
1ditP-4a4lA:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 6 CYH A 164
ASP A 233
VAL A 161
HIS A 168
 None
 1.21A 1ekjG-4a4lA:
undetectable
1ekjH-4a4lA:
undetectable		 1ekjG-4a4lA:
21.77
1ekjH-4a4lA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		5 / 12 ALA A 219
LYS A 284
ILE A 296
LEU A 299
ILE A 237
 None
 0.98A 1rb3B-4a4lA:
undetectable		 1rb3B-4a4lA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 ALA A  80
GLU A 101
CYH A 133
LEU A 167
HIS A 174
GLY A 193
 939  A1331 (-3.5A)
None
939  A1331 (-4.0A)
None
None
None
 0.71A 1uwhA-4a4lA:
24.5		 1uwhA-4a4lA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		7 / 12 ALA A  80
LYS A  82
GLU A 101
CYH A 133
LEU A 167
HIS A 174
GLY A 193
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
939  A1331 (-4.0A)
None
None
None
 0.71A 1uwhB-4a4lA:
24.3		 1uwhB-4a4lA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 ALA A  80
GLU A 101
CYH A 133
LEU A 167
HIS A 174
GLY A 193
 939  A1331 (-3.5A)
None
939  A1331 (-4.0A)
None
None
None
 0.71A 1uwjA-4a4lA:
6.7		 1uwjA-4a4lA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 ALA A  80
GLU A 101
CYH A 133
LEU A 167
HIS A 174
GLY A 193
 939  A1331 (-3.5A)
None
939  A1331 (-4.0A)
None
None
None
 0.71A 1uwjB-4a4lA:
6.7		 1uwjB-4a4lA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 7 ILE A 237
GLY A 238
LEU A 245
PHE A 305
 None
 0.92A 2vctD-4a4lA:
undetectable		 2vctD-4a4lA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		7 / 10 ARG A  57
LEU A  59
ALA A  80
LYS A  82
VAL A 114
LEU A 130
LEU A 132
 939  A1331 (-3.9A)
939  A1331 (-3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
939  A1331 ( 4.7A)
939  A1331 (-4.4A)
 0.76A 3aoxA-4a4lA:
23.5		 3aoxA-4a4lA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 LEU A  59
GLY A  60
ALA A  80
LYS A  82
VAL A 114
CYH A 133
 939  A1331 (-3.7A)
939  A1331 ( 4.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
939  A1331 (-4.0A)
 0.53A 3c7qA-4a4lA:
21.8		 3c7qA-4a4lA:
27.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 8 ALA A  80
LYS A  82
GLU A 101
LEU A 132
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
939  A1331 (-4.4A)
 0.43A 3lfaA-4a4lA:
19.1		 3lfaA-4a4lA:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		5 / 12 ALA A  80
LYS A  82
CYH A 133
PHE A 183
PHE A 195
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-4.0A)
None
 0.72A 3og7A-4a4lA:
18.3		 3og7A-4a4lA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 8 THR A 243
TYR A 268
TYR A 242
TRP A 235
 None
 1.24A 3wipD-4a4lA:
undetectable
3wipE-4a4lA:
undetectable		 3wipD-4a4lA:
20.74
3wipE-4a4lA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 8 VAL A 113
VAL A 114
CYH A 133
ILE A 192
 None
None
939  A1331 (-4.0A)
None
 0.48A 3wzeA-4a4lA:
16.6		 3wzeA-4a4lA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 8 VAL A 113
VAL A 114
ILE A 192
ASP A 194
 None
None
None
939  A1331 (-3.1A)
 0.55A 3wzeA-4a4lA:
16.6		 3wzeA-4a4lA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 LEU A  59
ALA A  80
LEU A 130
LEU A 132
GLY A 193
ASP A 194
 939  A1331 (-3.7A)
939  A1331 (-3.5A)
939  A1331 ( 4.7A)
939  A1331 (-4.4A)
None
939  A1331 (-3.1A)
 0.45A 3zbfA-4a4lA:
20.8		 3zbfA-4a4lA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		7 / 12 LEU A  59
GLY A  62
ALA A  80
LYS A  82
LEU A 130
LEU A 132
ASP A 194
 939  A1331 (-3.7A)
939  A1331 ( 3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 ( 4.7A)
939  A1331 (-4.4A)
939  A1331 (-3.1A)
 0.61A 4mkcA-4a4lA:
24.8		 4mkcA-4a4lA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		5 / 12 ALA A 219
LYS A 284
ILE A 296
LEU A 299
ILE A 237
 None
 1.07A 4nx6A-4a4lA:
undetectable		 4nx6A-4a4lA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		5 / 11 LEU A 182
VAL A 113
ILE A 296
VAL A 190
ILE A 192
 None
 0.97A 4qgiB-4a4lA:
undetectable		 4qgiB-4a4lA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 5 LEU A  59
VAL A 114
VAL A 128
ARG A 175
 939  A1331 (-3.7A)
None
None
None
 0.59A 4r7iA-4a4lA:
22.5		 4r7iA-4a4lA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 ALA A  80
LYS A  82
SER A 137
PHE A 183
GLY A 193
GLY A 196
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-3.5A)
939  A1331 (-4.0A)
None
None
 1.35A 4rzvA-4a4lA:
6.6		 4rzvA-4a4lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 ALA A  80
LYS A  82
SER A 137
PHE A 183
GLY A 193
PHE A 195
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-3.5A)
939  A1331 (-4.0A)
None
None
 0.92A 4rzvA-4a4lA:
6.6		 4rzvA-4a4lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 ALA A  80
LYS A  82
CYH A 133
PHE A 183
GLY A 193
GLY A 196
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-4.0A)
None
None
 1.36A 4rzvB-4a4lA:
23.7		 4rzvB-4a4lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 ALA A  80
LYS A  82
CYH A 133
PHE A 183
GLY A 193
PHE A 195
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-4.0A)
None
None
 0.90A 4rzvB-4a4lA:
23.7		 4rzvB-4a4lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 ALA A  80
LYS A  82
CYH A 133
SER A 137
PHE A 183
GLY A 193
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-3.5A)
939  A1331 (-4.0A)
None
 0.72A 4rzvB-4a4lA:
23.7		 4rzvB-4a4lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 10 LEU A  59
LEU A 108
VAL A 114
VAL A 128
ARG A 175
ILE A 192
 939  A1331 (-3.7A)
None
None
None
None
None
 0.82A 4u0iA-4a4lA:
22.8		 4u0iA-4a4lA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		7 / 12 ALA A  80
LYS A  82
CYH A 133
PHE A 183
GLY A 193
ASP A 194
PHE A 195
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-4.0A)
None
939  A1331 (-3.1A)
None
 0.68A 4xv2A-4a4lA:
18.4		 4xv2A-4a4lA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		7 / 12 ALA A  80
LYS A  82
CYH A 133
PHE A 183
GLY A 193
ASP A 194
PHE A 195
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-4.0A)
None
939  A1331 (-3.1A)
None
 0.65A 4xv2B-4a4lA:
24.7		 4xv2B-4a4lA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 ALA A  80
LYS A  82
CYH A 133
PHE A 183
GLY A 193
PHE A 195
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-4.0A)
None
None
 0.68A 5cswA-4a4lA:
24.3		 5cswA-4a4lA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 ALA A  80
LYS A  82
CYH A 133
PHE A 183
GLY A 193
PHE A 195
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-4.0A)
None
None
 0.71A 5cswB-4a4lA:
18.2		 5cswB-4a4lA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		7 / 12 ALA A  80
LYS A  82
GLU A 101
CYH A 133
LEU A 167
HIS A 174
GLY A 193
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
939  A1331 (-4.0A)
None
None
None
 0.78A 5hi2A-4a4lA:
15.2		 5hi2A-4a4lA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		5 / 12 GLY A  62
ALA A  80
LYS A  82
PHE A 183
GLY A 193
 939  A1331 ( 3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
None
 0.75A 5hieA-4a4lA:
23.5		 5hieA-4a4lA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		5 / 12 GLY A  62
ALA A  80
LYS A  82
PHE A 183
GLY A 193
 939  A1331 ( 3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
None
 0.77A 5hieB-4a4lA:
23.4		 5hieB-4a4lA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 GLY A  60
ALA A  80
LYS A  82
PHE A 183
GLY A 193
ASP A 194
 939  A1331 ( 4.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
None
939  A1331 (-3.1A)
 0.82A 5hieC-4a4lA:
20.4		 5hieC-4a4lA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 GLY A  60
GLY A  62
ALA A  80
LYS A  82
PHE A 183
GLY A 193
 939  A1331 ( 4.7A)
939  A1331 ( 3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
None
 0.83A 5hieC-4a4lA:
20.4		 5hieC-4a4lA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		5 / 12 GLY A  62
ALA A  80
LYS A  82
PHE A 183
GLY A 193
 939  A1331 ( 3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
None
 0.76A 5hieD-4a4lA:
23.7		 5hieD-4a4lA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 8 ALA A  80
GLU A 101
CYH A 133
ASP A 194
 939  A1331 (-3.5A)
None
939  A1331 (-4.0A)
939  A1331 (-3.1A)
 0.44A 5owrA-4a4lA:
24.3		 5owrA-4a4lA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 LEU A  59
ALA A  80
GLU A 101
VAL A 114
PHE A 183
GLY A 193
 939  A1331 (-3.7A)
939  A1331 (-3.5A)
None
None
939  A1331 (-4.0A)
None
 0.45A 5vcvA-4a4lA:
26.1		 5vcvA-4a4lA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 LEU A  59
ALA A  80
LYS A  82
GLU A 101
VAL A 114
PHE A 183
 939  A1331 (-3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
None
939  A1331 (-4.0A)
 0.60A 5vcvA-4a4lA:
26.1		 5vcvA-4a4lA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 5 HIS A 105
LEU A 132
CYH A 133
ASP A 194
 None
939  A1331 (-4.4A)
939  A1331 (-4.0A)
939  A1331 (-3.1A)
 0.72A 5vcvA-4a4lA:
26.1		 5vcvA-4a4lA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 4 VAL A 114
LEU A 132
ASN A 181
ASP A 194
 None
939  A1331 (-4.4A)
None
939  A1331 (-3.1A)
 0.80A 5vcyA-4a4lA:
26.0		 5vcyA-4a4lA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		7 / 12 ARG A  57
LEU A  59
ALA A  80
LYS A  82
GLU A 101
LEU A 132
CYH A 133
 939  A1331 (-3.9A)
939  A1331 (-3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
939  A1331 (-4.4A)
939  A1331 (-4.0A)
 0.89A 5y7zA-4a4lA:
28.4		 5y7zA-4a4lA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		7 / 12 ARG A  57
LEU A  59
ALA A  80
LYS A  82
GLU A 101
LEU A 132
CYH A 133
 939  A1331 (-3.9A)
939  A1331 (-3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
939  A1331 (-4.4A)
939  A1331 (-4.0A)
 0.89A 5y7zA-4a4lA:
28.4		 5y7zA-4a4lA:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		7 / 12 LEU A  59
ALA A  80
LYS A  82
GLU A 101
LEU A 132
CYH A 133
ASP A 194
 939  A1331 (-3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
939  A1331 (-4.4A)
939  A1331 (-4.0A)
939  A1331 (-3.1A)
 0.62A 5y80A-4a4lA:
27.9		 5y80A-4a4lA:
12.54