SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a4p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4a4p CYTOHESIN1
(Homo
sapiens) 		5 / 11 ALA A 115
ASN A 127
ILE A 101
LEU A  94
PHE A 104
 None
 1.30A 3fl9C-4a4pA:
undetectable		 3fl9C-4a4pA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4a4p CYTOHESIN1
(Homo
sapiens) 		5 / 12 GLU A 122
GLY A 121
VAL A 130
GLY A 117
PHE A 156
 None
 1.06A 3sglA-4a4pA:
undetectable		 3sglA-4a4pA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 4a4p CYTOHESIN1
(Homo
sapiens) 		4 / 7 ARG A 157
THR A 114
ASP A 118
GLY A 160
 None
 1.03A 5hwaA-4a4pA:
undetectable		 5hwaA-4a4pA:
20.82