SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a4y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4a4y PROTEIN MXIG
(Shigella
flexneri) 		4 / 8 LYS A 106
LEU A 105
PHE A 103
PHE A  79
 None
 0.72A 1v54C-4a4yA:
undetectable
1v54J-4a4yA:
undetectable		 1v54C-4a4yA:
19.17
1v54J-4a4yA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4a4y PROTEIN MXIG
(Shigella
flexneri) 		4 / 8 LYS A 106
LEU A 105
PHE A 103
PHE A  79
 None
 0.69A 1v54P-4a4yA:
undetectable
1v54W-4a4yA:
undetectable		 1v54P-4a4yA:
19.17
1v54W-4a4yA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4a4y PROTEIN MXIG
(Shigella
flexneri) 		4 / 8 LYS A 106
LEU A 105
PHE A 103
PHE A  79
 None
 0.72A 2dyrC-4a4yA:
undetectable
2dyrJ-4a4yA:
undetectable		 2dyrC-4a4yA:
19.17
2dyrJ-4a4yA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4a4y PROTEIN MXIG
(Shigella
flexneri) 		4 / 8 LYS A 106
LEU A 105
PHE A 103
PHE A  79
 None
 0.67A 2dyrP-4a4yA:
undetectable
2dyrW-4a4yA:
undetectable		 2dyrP-4a4yA:
19.17
2dyrW-4a4yA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4a4y PROTEIN MXIG
(Shigella
flexneri) 		4 / 8 LYS A 106
LEU A 105
PHE A 103
PHE A  79
 None
 0.67A 2eikP-4a4yA:
undetectable
2eikW-4a4yA:
undetectable		 2eikP-4a4yA:
19.17
2eikW-4a4yA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4a4y PROTEIN MXIG
(Shigella
flexneri) 		4 / 8 LYS A 106
LEU A 105
PHE A 103
PHE A  79
 None
 0.73A 2eilC-4a4yA:
undetectable
2eilJ-4a4yA:
undetectable		 2eilC-4a4yA:
19.17
2eilJ-4a4yA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4a4y PROTEIN MXIG
(Shigella
flexneri) 		4 / 7 LYS A 106
LEU A 105
PHE A 103
PHE A  79
 None
 0.65A 2eimP-4a4yA:
undetectable
2eimW-4a4yA:
undetectable		 2eimP-4a4yA:
19.17
2eimW-4a4yA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4a4y PROTEIN MXIG
(Shigella
flexneri) 		5 / 12 PRO A  57
VAL A  58
PHE A  96
ILE A  67
PHE A 103
 None
 1.30A 2v95A-4a4yA:
undetectable		 2v95A-4a4yA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4a4y PROTEIN MXIG
(Shigella
flexneri) 		4 / 7 LYS A 106
LEU A 105
PHE A 103
PHE A  79
 None
 0.69A 3asnP-4a4yA:
undetectable
3asnW-4a4yA:
undetectable		 3asnP-4a4yA:
19.17
3asnW-4a4yA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4a4y PROTEIN MXIG
(Shigella
flexneri) 		4 / 7 LYS A 106
LEU A 105
PHE A 103
PHE A  79
 None
 0.67A 3asoP-4a4yA:
undetectable
3asoW-4a4yA:
undetectable		 3asoP-4a4yA:
19.17
3asoW-4a4yA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4a4y PROTEIN MXIG
(Shigella
flexneri) 		5 / 12 ILE A  89
PHE A  96
ILE A  35
VAL A  58
LEU A  37
 None
 1.08A 3w67B-4a4yA:
undetectable		 3w67B-4a4yA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4a4y PROTEIN MXIG
(Shigella
flexneri) 		4 / 7 LYS A 106
LEU A 105
PHE A 103
PHE A  79
 None
 0.69A 5b3sP-4a4yA:
undetectable		 5b3sP-4a4yA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4a4y PROTEIN MXIG
(Shigella
flexneri) 		4 / 6 LYS A 106
LEU A 105
PHE A 103
PHE A  79
 None
 0.65A 5x19P-4a4yA:
undetectable		 5x19P-4a4yA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4a4y PROTEIN MXIG
(Shigella
flexneri) 		4 / 7 LYS A 106
LEU A 105
PHE A 103
PHE A  79
 None
 0.70A 5x1fP-4a4yA:
undetectable
5x1fW-4a4yA:
undetectable		 5x1fP-4a4yA:
19.17
5x1fW-4a4yA:
16.54