SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a4z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 11 LEU A1171
MET A1212
VAL A1215
LEU A1129
LEU A1132
 None
 1.04A 1dtlA-4a4zA:
undetectable		 1dtlA-4a4zA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 7 ARG A1095
ASN A 813
ARG A 454
ASN A1122
 None
 1.46A 1f9gA-4a4zA:
2.9		 1f9gA-4a4zA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 6 THR A 793
VAL A 792
LEU A 752
ALA A 761
 None
 0.95A 2e1qA-4a4zA:
2.3		 2e1qA-4a4zA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 6 THR A 793
VAL A 792
LEU A 752
ALA A 761
 None
 0.96A 2e1qC-4a4zA:
undetectable		 2e1qC-4a4zA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 391
GLU A 708
LEU A 731
LEU A 384
 None
EDO  A2291 (-2.7A)
None
None
 0.89A 2q0iA-4a4zA:
undetectable		 2q0iA-4a4zA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 7 SER A1123
ILE A1121
THR A1102
ILE A1248
 None
 0.95A 2v0mB-4a4zA:
undetectable		 2v0mB-4a4zA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 499
ALA A 351
ILE A 442
VAL A 347
THR A 501
 None
 1.17A 2w3aA-4a4zA:
undetectable		 2w3aA-4a4zA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 8 THR A 793
VAL A 792
LEU A 752
ALA A 761
 None
 1.02A 3ax7A-4a4zA:
undetectable		 3ax7A-4a4zA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 404
GLY A 402
ILE A 401
VAL A 438
ILE A 376
 None
 1.25A 3ekyB-4a4zA:
undetectable		 3ekyB-4a4zA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 762
GLN A 759
ILE A 510
VAL A 775
VAL A 736
 None
 1.43A 3fi0C-4a4zA:
undetectable		 3fi0C-4a4zA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 784
SER A 785
PHE A 789
ILE A 741
 None
 0.83A 3ko0B-4a4zA:
undetectable		 3ko0B-4a4zA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 784
SER A 785
PHE A 789
ILE A 741
 None
 0.84A 3ko0S-4a4zA:
undetectable		 3ko0S-4a4zA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 446
VAL A 449
TRP A 458
 None
 0.97A 3l8lC-4a4zA:
undetectable
3l8lD-4a4zA:
undetectable		 3l8lC-4a4zA:
1.31
3l8lD-4a4zA:
1.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1248
PHE A1153
LEU A1245
VAL A1215
LEU A1171
 None
 1.21A 3ozuA-4a4zA:
undetectable		 3ozuA-4a4zA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 699
ALA A 643
ASP A 644
LEU A 687
 None
 1.03A 3rozA-4a4zA:
undetectable		 3rozA-4a4zA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 7 THR A 793
VAL A 792
LEU A 752
ALA A 761
 None
 1.01A 3uniA-4a4zA:
undetectable		 3uniA-4a4zA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPW_A_NCAA412_0
(OLD YELLOW ENZYME
2.6 (OYE2.6), NADPH
DEHYDROGENASE)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 9 THR A 358
ALA A 361
ILE A 442
TYR A 377
ASN A 730
 ANP  A2288 (-3.5A)
None
None
None
None
 1.49A 3upwA-4a4zA:
undetectable		 3upwA-4a4zA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		3 / 3 GLY A1124
SER A1123
TRP A1244
 None
 0.73A 4e7cD-4a4zA:
1.0		 4e7cD-4a4zA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		3 / 3 PHE A1189
TYR A1125
TYR A1182
 None
 0.88A 4ffwA-4a4zA:
undetectable		 4ffwA-4a4zA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 533
ILE A 519
PRO A 520
PHE A 789
 None
 1.27A 4fgkA-4a4zA:
undetectable		 4fgkA-4a4zA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 780
ASP A 607
SER A 782
ALA A 779
 None
 1.23A 4lv9A-4a4zA:
undetectable
4lv9B-4a4zA:
undetectable		 4lv9A-4a4zA:
19.48
4lv9B-4a4zA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 761
ILE A 510
LEU A 518
LEU A 621
ILE A 737
 None
 0.96A 4m2xA-4a4zA:
undetectable		 4m2xA-4a4zA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 761
ILE A 510
LEU A 518
LEU A 621
ILE A 737
 None
 1.03A 4m2xC-4a4zA:
undetectable		 4m2xC-4a4zA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 761
ILE A 510
LEU A 518
LEU A 621
ILE A 737
 None
 1.08A 4m2xE-4a4zA:
undetectable		 4m2xE-4a4zA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 836
LYS A 827
ASN A 833
 None
 1.10A 4y1dA-4a4zA:
undetectable
4y1dD-4a4zA:
undetectable		 4y1dA-4a4zA:
11.32
4y1dD-4a4zA:
0.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 12 PHE A1209
ILE A1181
PHE A1137
LEU A1138
PHE A1153
 None
 1.13A 5b8iC-4a4zA:
undetectable		 5b8iC-4a4zA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 721
THR A 722
VAL A 633
HIS A 695
 None
EDO  A2290 (-3.1A)
None
None
 0.90A 5eckA-4a4zA:
undetectable		 5eckA-4a4zA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 721
THR A 722
VAL A 633
HIS A 695
 None
EDO  A2290 (-3.1A)
None
None
 0.91A 5eckD-4a4zA:
undetectable		 5eckD-4a4zA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 721
THR A 722
VAL A 633
HIS A 695
 None
EDO  A2290 (-3.1A)
None
None
 0.96A 5eclA-4a4zA:
undetectable		 5eclA-4a4zA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 721
THR A 722
VAL A 633
HIS A 695
 None
EDO  A2290 (-3.1A)
None
None
 0.99A 5ecoA-4a4zA:
undetectable		 5ecoA-4a4zA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 7 VAL A1252
LEU A1264
GLU A1251
LEU A1150
 None
 0.63A 5jq7A-4a4zA:
undetectable		 5jq7A-4a4zA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 536
LYS A 537
PHE A 533
 None
 1.22A 5klaA-4a4zA:
undetectable		 5klaA-4a4zA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 450
THR A 798
GLN A 759
GLY A 755
 None
 0.93A 5nzxA-4a4zA:
undetectable		 5nzxA-4a4zA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 7 ASN A 450
THR A 798
GLN A 759
GLY A 755
 None
 1.01A 5nzyA-4a4zA:
3.0		 5nzyA-4a4zA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 767
ARG A 504
ARG A 766
 ANP  A2288 (-3.5A)
None
None
 0.84A 5vcgA-4a4zA:
undetectable		 5vcgA-4a4zA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		3 / 3 TYR A1286
LEU A 384
ASP A 444
 None
 0.62A 5zv2B-4a4zA:
undetectable		 5zv2B-4a4zA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 709
LEU A 688
HIS A 695
ALA A 693
 None
 0.97A 6ck2C-4a4zA:
undetectable
6ck2D-4a4zA:
undetectable		 6ck2C-4a4zA:
4.41
6ck2D-4a4zA:
2.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4a4z ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 6 THR A 353
ARG A 504
PRO A 732
ARG A 763
 ANP  A2288 (-3.5A)
None
None
ANP  A2288 (-3.5A)
 1.21A 6ef6A-4a4zA:
undetectable		 6ef6A-4a4zA:
15.55