SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a56'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4a56 PULLULANASE
SECRETION PROTEIN
PULS
(Klebsiella
oxytoca) 		5 / 12 LEU A  96
VAL A  42
GLY A  45
ALA A  46
LEU A  58
 None
 1.08A 1pxxC-4a56A:
undetectable		 1pxxC-4a56A:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4a56 PULLULANASE
SECRETION PROTEIN
PULS
(Klebsiella
oxytoca) 		4 / 6 ASN A  54
GLU A 103
TYR A  48
LEU A  49
 MRD  A1123 (-4.3A)
None
None
None
 1.18A 4twdB-4a56A:
undetectable
4twdC-4a56A:
undetectable		 4twdB-4a56A:
15.73
4twdC-4a56A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4a56 PULLULANASE
SECRETION PROTEIN
PULS
(Klebsiella
oxytoca) 		4 / 6 ASN A  54
GLU A 103
TYR A  48
LEU A  49
 MRD  A1123 (-4.3A)
None
None
None
 1.15A 4twdD-4a56A:
undetectable
4twdE-4a56A:
undetectable		 4twdD-4a56A:
15.73
4twdE-4a56A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4a56 PULLULANASE
SECRETION PROTEIN
PULS
(Klebsiella
oxytoca) 		4 / 6 ASN A  54
GLU A 103
TYR A  48
LEU A  49
 MRD  A1123 (-4.3A)
None
None
None
 1.27A 4twdI-4a56A:
undetectable
4twdJ-4a56A:
undetectable		 4twdI-4a56A:
15.73
4twdJ-4a56A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4a56 PULLULANASE
SECRETION PROTEIN
PULS
(Klebsiella
oxytoca) 		5 / 12 LEU A  96
VAL A  42
GLY A  45
ALA A  46
LEU A  58
 None
 1.03A 5ikqA-4a56A:
undetectable		 5ikqA-4a56A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4a56 PULLULANASE
SECRETION PROTEIN
PULS
(Klebsiella
oxytoca) 		5 / 12 LEU A  96
VAL A  42
GLY A  45
ALA A  46
LEU A  58
 None
 1.07A 5ikqB-4a56A:
undetectable		 5ikqB-4a56A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4a56 PULLULANASE
SECRETION PROTEIN
PULS
(Klebsiella
oxytoca) 		5 / 12 LEU A  96
VAL A  42
GLY A  45
ALA A  46
LEU A  58
 None
 1.06A 5iktA-4a56A:
undetectable		 5iktA-4a56A:
11.01