SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a5g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 4a5g ANIONIC PEROXIDASE
(Raphanus
sativus) 		4 / 8 HIS A 171
GLY A 174
LEU A 245
ASP A 248
 HEM  A1307 (-3.4A)
HEM  A1307 (-3.3A)
HEM  A1307 ( 4.7A)
None
 0.41A 1aegA-4a5gA:
24.3		 1aegA-4a5gA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 4a5g ANIONIC PEROXIDASE
(Raphanus
sativus) 		5 / 12 PHE A 266
LEU A 272
ALA A 276
ALA A 166
THR A 161
 None
NAG  A1324 (-3.9A)
None
None
None
 1.04A 1cbsA-4a5gA:
undetectable		 1cbsA-4a5gA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 4a5g ANIONIC PEROXIDASE
(Raphanus
sativus) 		4 / 7 PHE A 273
SER A 265
SER A 280
ALA A 276
 None
 1.18A 1fxvA-4a5gA:
undetectable
1fxvB-4a5gA:
undetectable		 1fxvA-4a5gA:
20.68
1fxvB-4a5gA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4a5g ANIONIC PEROXIDASE
(Raphanus
sativus) 		5 / 9 ALA A 131
ASN A  72
ILE A 140
ILE A  55
THR A 130
 None
 1.27A 1j3jB-4a5gA:
undetectable		 1j3jB-4a5gA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4a5g ANIONIC PEROXIDASE
(Raphanus
sativus) 		5 / 12 ALA A 106
SER A 107
SER A  17
ALA A  88
ILE A  23
 None
 1.16A 1nt2A-4a5gA:
undetectable		 1nt2A-4a5gA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 4a5g ANIONIC PEROXIDASE
(Raphanus
sativus) 		5 / 12 PHE A 266
LEU A 272
ALA A 276
ALA A 166
THR A 161
 None
NAG  A1324 (-3.9A)
None
None
None
 1.00A 2fr3A-4a5gA:
undetectable		 2fr3A-4a5gA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4a5g ANIONIC PEROXIDASE
(Raphanus
sativus) 		3 / 3 SER A  37
ASP A 228
ASP A  31
 HEM  A1307 (-2.6A)
None
None
 0.81A 2plwA-4a5gA:
undetectable		 2plwA-4a5gA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 4a5g ANIONIC PEROXIDASE
(Raphanus
sativus) 		5 / 10 ILE A  34
ASP A  31
LEU A 103
THR A 128
ILE A 140
 None
 1.24A 3prsA-4a5gA:
undetectable		 3prsA-4a5gA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 4a5g ANIONIC PEROXIDASE
(Raphanus
sativus) 		4 / 6 THR A   7
ASN A   5
ASP A 122
ILE A 282
 NAG  A1310 ( 4.5A)
NAG  A1310 (-1.9A)
None
None
 1.42A 3w9tB-4a5gA:
undetectable		 3w9tB-4a5gA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 4a5g ANIONIC PEROXIDASE
(Raphanus
sativus) 		5 / 11 SER A 107
PHE A 277
PHE A 173
SER A 114
PHE A 230
 None
None
HEM  A1307 (-4.8A)
None
None
 1.44A 4evrA-4a5gA:
undetectable		 4evrA-4a5gA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 4a5g ANIONIC PEROXIDASE
(Raphanus
sativus) 		4 / 7 ALA A  36
LEU A  38
SER A 110
SER A 114
 HEM  A1307 (-3.5A)
None
None
None
 0.94A 4iklA-4a5gA:
undetectable
4iklB-4a5gA:
undetectable		 4iklA-4a5gA:
17.86
4iklB-4a5gA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4a5g ANIONIC PEROXIDASE
(Raphanus
sativus) 		4 / 8 ALA A 131
GLU A  66
GLN A 133
ASP A  58
 None
CA  A1308 ( 4.5A)
NAG  A1316 (-3.8A)
None
 0.89A 4kttB-4a5gA:
undetectable		 4kttB-4a5gA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 4a5g ANIONIC PEROXIDASE
(Raphanus
sativus) 		4 / 5 PHE A 235
HIS A 171
LEU A 245
PRO A 143
 None
HEM  A1307 (-3.4A)
HEM  A1307 ( 4.7A)
HEM  A1307 (-4.1A)
 1.43A 4o8zA-4a5gA:
undetectable		 4o8zA-4a5gA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4a5g ANIONIC PEROXIDASE
(Raphanus
sativus) 		4 / 7 THR A 161
LEU A 164
THR A 254
THR A 151
 None
 0.82A 4z90A-4a5gA:
undetectable
4z90B-4a5gA:
undetectable
4z90C-4a5gA:
undetectable
4z90D-4a5gA:
undetectable
4z90E-4a5gA:
undetectable		 4z90A-4a5gA:
19.53
4z90B-4a5gA:
19.53
4z90C-4a5gA:
19.53
4z90D-4a5gA:
19.53
4z90E-4a5gA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4a5g ANIONIC PEROXIDASE
(Raphanus
sativus) 		4 / 8 THR A 161
LEU A 164
THR A 254
THR A 151
 None
 0.77A 4z90F-4a5gA:
undetectable
4z90G-4a5gA:
undetectable
4z90H-4a5gA:
undetectable
4z90I-4a5gA:
undetectable
4z90J-4a5gA:
undetectable		 4z90F-4a5gA:
19.53
4z90G-4a5gA:
19.53
4z90H-4a5gA:
19.53
4z90I-4a5gA:
19.53
4z90J-4a5gA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4a5g ANIONIC PEROXIDASE
(Raphanus
sativus) 		4 / 7 THR A 161
LEU A 164
THR A 254
THR A 151
 None
 0.83A 4z91F-4a5gA:
undetectable
4z91G-4a5gA:
undetectable
4z91H-4a5gA:
undetectable
4z91I-4a5gA:
undetectable
4z91J-4a5gA:
1.3		 4z91F-4a5gA:
19.53
4z91G-4a5gA:
19.53
4z91H-4a5gA:
19.53
4z91I-4a5gA:
19.53
4z91J-4a5gA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4a5g ANIONIC PEROXIDASE
(Raphanus
sativus) 		4 / 7 THR A 254
THR A 151
THR A 161
LEU A 164
 None
 0.90A 4z91F-4a5gA:
undetectable
4z91G-4a5gA:
undetectable
4z91H-4a5gA:
undetectable
4z91I-4a5gA:
undetectable
4z91J-4a5gA:
1.3		 4z91F-4a5gA:
19.53
4z91G-4a5gA:
19.53
4z91H-4a5gA:
19.53
4z91I-4a5gA:
19.53
4z91J-4a5gA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4a5g ANIONIC PEROXIDASE
(Raphanus
sativus) 		5 / 12 ILE A  55
VAL A  82
ALA A 109
ALA A 106
VAL A 102
 None
 1.26A 5igpA-4a5gA:
undetectable		 5igpA-4a5gA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 4a5g ANIONIC PEROXIDASE
(Raphanus
sativus) 		5 / 12 ALA A 166
GLY A 169
SER A 168
LEU A 251
ASP A 223
 None
None
HEM  A1307 (-3.6A)
None
CA  A1309 (-3.3A)
 1.42A 5vlmF-4a5gA:
undetectable		 5vlmF-4a5gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4a5g ANIONIC PEROXIDASE
(Raphanus
sativus) 		3 / 3 ASP A  31
SER A 110
SER A 114
 None
 0.69A 6mxtA-4a5gA:
undetectable		 6mxtA-4a5gA:
20.45