SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a5o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		4 / 8 PHE A  63
ILE A  19
PRO A  34
LEU A 276
 None
 0.85A 1hmyA-4a5oA:
undetectable		 1hmyA-4a5oA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		4 / 4 ASP A  84
LEU A  79
LEU A  82
LEU A  80
 None
 1.29A 1u18A-4a5oA:
undetectable		 1u18A-4a5oA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 137
VAL A  38
ILE A 114
ARG A 268
 None
 0.95A 2hyyA-4a5oA:
undetectable		 2hyyA-4a5oA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		5 / 12 VAL A  38
ILE A  92
VAL A 120
LEU A 271
THR A 275
 None
 1.03A 2jn3A-4a5oA:
undetectable		 2jn3A-4a5oA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 230
ALA A 209
PRO A 265
THR A 267
 None
 1.04A 2q6oA-4a5oA:
3.4		 2q6oA-4a5oA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		4 / 8 ARG A 239
SER A 152
VAL A 263
GLY A 262
 None
 1.07A 2qd3A-4a5oA:
3.5		 2qd3A-4a5oA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 101
PRO A 102
LEU A 105
 None
 0.50A 2qd5B-4a5oA:
2.9		 2qd5B-4a5oA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		5 / 12 LEU A   5
VAL A 227
ILE A 221
GLY A 218
ILE A 256
 None
 1.07A 2r5pA-4a5oA:
undetectable		 2r5pA-4a5oA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		5 / 12 LEU A   5
VAL A 227
ILE A 221
GLY A 218
ILE A 256
 None
 1.07A 2r5pC-4a5oA:
undetectable		 2r5pC-4a5oA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 171
ASP A 121
ILE A 232
ASN A 169
 None
 1.04A 3avpA-4a5oA:
2.7		 3avpA-4a5oA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		6 / 12 ARG A  32
GLY A  94
VAL A  38
ALA A 278
THR A 275
LEU A 271
 None
 1.34A 3dh0B-4a5oA:
undetectable		 3dh0B-4a5oA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 162
ASP A 161
ASP A 204
GLY A 183
ILE A 146
 None
 0.96A 3s53A-4a5oA:
undetectable		 3s53A-4a5oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 101
PRO A 102
LEU A 105
 None
 0.49A 3w1wB-4a5oA:
3.7		 3w1wB-4a5oA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  15
ILE A  19
ARG A  22
 None
 0.70A 4mk4B-4a5oA:
3.5		 4mk4B-4a5oA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		3 / 3 PRO A 102
LEU A 101
GLN A  76
 None
 0.65A 4pevB-4a5oA:
4.4		 4pevB-4a5oA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  52
VAL A  51
LEU A  86
ALA A  67
LEU A  70
 None
 1.02A 4qrcA-4a5oA:
undetectable		 4qrcA-4a5oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		3 / 3 ASP A  57
HIS A  53
LYS A  54
 None
 0.83A 4qzuD-4a5oA:
undetectable		 4qzuD-4a5oA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 211
GLY A 145
VAL A 263
ILE A 146
GLY A 166
 None
 0.78A 5koxA-4a5oA:
undetectable		 5koxA-4a5oA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		4 / 4 GLU A 178
PRO A 174
ILE A 128
LEU A 131
 None
 1.34A 5m45D-4a5oA:
undetectable		 5m45D-4a5oA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		4 / 8 ILE A 226
ALA A 253
LEU A   5
ILE A 228
 None
 0.88A 5uihA-4a5oA:
undetectable		 5uihA-4a5oA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 264
GLY A 262
ILE A  11
LEU A  15
ALA A 269
 None
 0.89A 5vm8B-4a5oA:
2.8		 5vm8B-4a5oA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		4 / 8 TYR A 126
ASP A 119
ASP A 121
PRO A 140
 None
 0.94A 6ag0A-4a5oA:
undetectable		 6ag0A-4a5oA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		4 / 8 TYR A 126
ASP A 119
ASP A 121
PRO A 140
 None
 1.02A 6ag0C-4a5oA:
undetectable		 6ag0C-4a5oA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		7 / 12 LEU A  96
GLN A  98
LEU A  99
PRO A 100
ASP A 121
THR A 142
VAL A 171
 None
 1.02A 6debB-4a5oA:
36.8		 6debB-4a5oA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		7 / 12 LEU A  96
GLN A  98
PRO A 100
ASP A 121
THR A 142
VAL A 171
THR A 267
 None
 0.79A 6debB-4a5oA:
36.8		 6debB-4a5oA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		5 / 12 PRO A 100
THR A 142
ILE A 170
VAL A 171
THR A 267
 None
 1.04A 6debB-4a5oA:
36.8		 6debB-4a5oA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		4 / 5 TYR A  50
LYS A  54
GLN A  98
GLY A 211
 None
 0.88A 6debB-4a5oA:
36.8		 6debB-4a5oA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  94
LEU A  36
GLY A  35
ASP A 119
ASN A 274
 None
None
None
None
GOL  A1285 (-3.4A)
 1.10A 6mhtA-4a5oA:
2.5		 6mhtA-4a5oA:
21.97