SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a5p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 4a5p PROTEIN MXIA
(Shigella
flexneri) 		3 / 3 LEU A 658
ARG A 657
ILE A 659
 None
None
MLY  A 656 ( 4.3A)
 0.66A 2xn5B-4a5pA:
undetectable		 2xn5B-4a5pA:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4a5p PROTEIN MXIA
(Shigella
flexneri) 		4 / 6 TYR A 671
VAL A 644
ILE A 579
ARG A 657
 None
MLY  A 590 ( 4.3A)
None
None
 1.01A 3pyyA-4a5pA:
undetectable		 3pyyA-4a5pA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4a5p PROTEIN MXIA
(Shigella
flexneri) 		5 / 12 TYR A 483
LEU A 486
SER A 477
PHE A 428
PHE A 367
 None
None
MLY  A 476 ( 4.9A)
None
None
 1.49A 3ugrA-4a5pA:
undetectable		 3ugrA-4a5pA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4a5p PROTEIN MXIA
(Shigella
flexneri) 		3 / 3 LEU A 537
ARG A 536
MET A 617
 None
 0.70A 4m11C-4a5pA:
undetectable		 4m11C-4a5pA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4a5p PROTEIN MXIA
(Shigella
flexneri) 		5 / 9 LEU A 538
GLY A 499
VAL A 394
VAL A 544
LEU A 547
 None
 1.18A 4qd3A-4a5pA:
undetectable		 4qd3A-4a5pA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 4a5p PROTEIN MXIA
(Shigella
flexneri) 		4 / 8 ARG A 652
ARG A 657
VAL A 668
ASP A 660
 MLY  A 656 ( 4.7A)
None
MLY  A 656 ( 4.5A)
MLY  A 664 ( 3.1A)
 0.96A 4xqgA-4a5pA:
undetectable		 4xqgA-4a5pA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 4a5p PROTEIN MXIA
(Shigella
flexneri) 		4 / 8 ARG A 652
ARG A 657
VAL A 668
ASP A 660
 MLY  A 656 ( 4.7A)
None
MLY  A 656 ( 4.5A)
MLY  A 664 ( 3.1A)
 0.99A 4xqgB-4a5pA:
undetectable		 4xqgB-4a5pA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4a5p PROTEIN MXIA
(Shigella
flexneri) 		4 / 6 ARG A 653
ILE A 619
ILE A 565
ASP A 563
 None
 1.22A 4z4dA-4a5pA:
2.0		 4z4dA-4a5pA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a5p PROTEIN MXIA
(Shigella
flexneri) 		4 / 7 ILE A 542
PHE A 643
ILE A 666
CYH A 580
 None
MLY  A 641 ( 4.5A)
None
None
 0.99A 5hieC-4a5pA:
undetectable		 5hieC-4a5pA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 4a5p PROTEIN MXIA
(Shigella
flexneri) 		4 / 6 MET A 593
ASN A 642
VAL A 644
LEU A 646
 None
MLY  A 641 ( 4.2A)
MLY  A 590 ( 4.3A)
None
 1.21A 5xdhA-4a5pA:
undetectable
5xdhC-4a5pA:
undetectable		 5xdhA-4a5pA:
11.37
5xdhC-4a5pA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4a5p PROTEIN MXIA
(Shigella
flexneri) 		4 / 6 SER A 553
GLU A 569
ARG A 572
ASP A 650
 None
 1.21A 5zw4A-4a5pA:
undetectable		 5zw4A-4a5pA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 4a5p PROTEIN MXIA
(Shigella
flexneri) 		5 / 9 ILE A 602
ILE A 606
GLU A 624
VAL A 621
ILE A 619
 None
 1.45A 6hloA-4a5pA:
undetectable		 6hloA-4a5pA:
21.70