SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a5w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		4 / 8 VAL A 857
LEU A 825
SER A 893
VAL A 888
 None
 1.21A 1jtvA-4a5wA:
undetectable		 1jtvA-4a5wA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		3 / 3 VAL A 609
ALA A 608
HIS A 226
 None
 0.68A 1q23C-4a5wA:
undetectable		 1q23C-4a5wA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		3 / 3 VAL A 609
ALA A 608
HIS A 226
 None
 0.73A 1q23H-4a5wA:
undetectable		 1q23H-4a5wA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		3 / 3 VAL A 609
ALA A 608
HIS A 226
 None
 0.66A 1q23G-4a5wA:
undetectable		 1q23G-4a5wA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		3 / 3 VAL A 609
ALA A 608
HIS A 226
 None
 0.69A 1q23J-4a5wA:
undetectable		 1q23J-4a5wA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		5 / 12 ILE A  87
ALA A  35
PHE A  31
ILE A  39
LEU A 104
 None
 1.10A 1tdrA-4a5wA:
undetectable		 1tdrA-4a5wA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		4 / 7 MET A 173
LEU A1309
PRO A1337
VAL A 979
 None
 1.20A 2hrcA-4a5wA:
undetectable		 2hrcA-4a5wA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		5 / 12 GLY A 633
ALA A 649
GLY A 637
ALA A 636
LEU A 651
 None
 1.00A 2nyuA-4a5wA:
undetectable		 2nyuA-4a5wA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		5 / 9 PHE A  31
ASP A 631
LEU A 632
GLY A 507
THR A 652
 None
 1.49A 2tsrD-4a5wA:
undetectable		 2tsrD-4a5wA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		5 / 10 PHE A1147
ALA A1080
ALA A1082
LEU A1012
VAL A1016
 None
 1.16A 2wuzA-4a5wA:
undetectable		 2wuzA-4a5wA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		5 / 10 PHE A1147
ALA A1080
ALA A1082
LEU A1012
VAL A1016
 None
 1.15A 2wuzB-4a5wA:
undetectable		 2wuzB-4a5wA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_B_TC9B1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		5 / 11 SER A 114
THR A  53
SER A  68
SER A  55
SER A  65
 None
 1.33A 2xytB-4a5wA:
0.0
2xytC-4a5wA:
1.0
2xytG-4a5wA:
2.4		 2xytB-4a5wA:
9.40
2xytC-4a5wA:
9.40
2xytG-4a5wA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		3 / 3 ASN A 242
ASP A 377
GLN A 381
 None
 0.75A 3eeyC-4a5wA:
undetectable		 3eeyC-4a5wA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		3 / 3 ASN A 242
ASP A 377
GLN A 381
 None
 0.75A 3eeyD-4a5wA:
undetectable		 3eeyD-4a5wA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		3 / 3 ASN A 242
ASP A 377
GLN A 381
 None
 0.74A 3eeyE-4a5wA:
undetectable		 3eeyE-4a5wA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		4 / 8 SER A1184
PHE A1186
LEU A1144
TRP A1077
 None
 0.95A 3jq7B-4a5wA:
undetectable		 3jq7B-4a5wA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		4 / 7 GLU A 338
HIS A 226
VAL A 260
ALA A 252
 None
 1.06A 3kp6B-4a5wA:
undetectable		 3kp6B-4a5wA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		3 / 3 SER A1055
GLY A1052
SER A1014
 None
 0.63A 3loqA-4a5wA:
undetectable		 3loqA-4a5wA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		5 / 12 PHE A 269
GLU A 341
ILE A 342
ALA A 340
ILE A 248
 None
 1.20A 3ndiA-4a5wA:
undetectable		 3ndiA-4a5wA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		4 / 7 ASP A 165
ILE A 976
VAL A1364
ARG A 936
 None
 1.02A 3p6hA-4a5wA:
undetectable		 3p6hA-4a5wA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		4 / 6 ILE A1432
GLU A1481
PHE A1477
ALA A1434
 None
 0.99A 3pgyA-4a5wA:
2.4
3pgyB-4a5wA:
undetectable		 3pgyA-4a5wA:
14.52
3pgyB-4a5wA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		5 / 9 LEU A 541
LEU A 504
ILE A  39
ILE A  41
PHE A 646
 None
 1.15A 3tmzA-4a5wA:
undetectable		 3tmzA-4a5wA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		3 / 3 LYS A1400
THR A1383
ILE A1514
 None
 0.92A 4e0fB-4a5wA:
2.2		 4e0fB-4a5wA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		4 / 8 TYR A1326
LEU A1346
VAL A1340
VAL A1338
 None
 1.01A 4em2A-4a5wA:
undetectable		 4em2A-4a5wA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		4 / 7 ILE A1426
GLY A1431
ALA A1434
GLN A 840
 None
 0.96A 4g0uB-4a5wA:
undetectable		 4g0uB-4a5wA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		4 / 4 ILE A 528
ASN A 483
ILE A 485
VAL A 486
 None
 1.30A 4uy87-4a5wA:
undetectable		 4uy87-4a5wA:
1.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		3 / 3 TYR A 266
THR A 268
THR A 328
 None
 0.78A 5aoxB-4a5wA:
2.7		 5aoxB-4a5wA:
5.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		3 / 3 TYR A 266
THR A 268
THR A 328
 None
 0.82A 5aoxE-4a5wA:
2.5		 5aoxE-4a5wA:
5.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		5 / 12 LEU A 590
SER A 589
GLN A 787
VAL A 780
VAL A 600
 None
 1.13A 5dpdA-4a5wA:
3.8		 5dpdA-4a5wA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		5 / 12 LEU A 590
SER A 589
GLN A 787
VAL A 780
VAL A 600
 None
 1.11A 5dpdB-4a5wA:
3.5		 5dpdB-4a5wA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		4 / 6 THR A1566
ALA A1579
THR A1580
VAL A1563
 None
 0.97A 5ecoA-4a5wA:
undetectable		 5ecoA-4a5wA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		3 / 3 ARG A1279
THR A1290
ASP A1289
 None
 0.90A 5g5gA-4a5wA:
undetectable
5g5gB-4a5wA:
undetectable		 5g5gA-4a5wA:
9.57
5g5gB-4a5wA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		5 / 12 ILE A 345
GLY A 344
TYR A 347
GLU A 247
ILE A 267
 None
 1.22A 5igwA-4a5wA:
undetectable		 5igwA-4a5wA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_A_ACTA305_0
(CARBONIC ANHYDRASE 4)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		4 / 4 GLN A 532
VAL A 535
GLU A 564
ILE A 563
 None
 1.37A 5jncA-4a5wA:
undetectable		 5jncA-4a5wA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		3 / 3 THR A1511
SER A1510
TYR A1509
 None
 0.87A 5jsdA-4a5wA:
undetectable		 5jsdA-4a5wA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		3 / 3 THR A1511
SER A1510
TYR A1509
 None
 0.88A 5jsdB-4a5wA:
undetectable		 5jsdB-4a5wA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		3 / 3 THR A1511
SER A1510
TYR A1509
 None
 0.87A 5jsdC-4a5wA:
undetectable		 5jsdC-4a5wA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		3 / 3 THR A1511
SER A1510
TYR A1509
 None
 0.87A 5jseA-4a5wA:
undetectable		 5jseA-4a5wA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		3 / 3 THR A1511
SER A1510
TYR A1509
 None
 0.86A 5jseB-4a5wA:
undetectable		 5jseB-4a5wA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		3 / 3 THR A1511
SER A1510
TYR A1509
 None
 0.87A 5jseC-4a5wA:
undetectable		 5jseC-4a5wA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_B_PFLB410_1
(PROTON-GATED ION
CHANNEL)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		5 / 9 TYR A 146
ILE A 182
ILE A 804
TRP A 599
VAL A 777
 None
 1.40A 5mvnB-4a5wA:
undetectable		 5mvnB-4a5wA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		4 / 5 SER A 303
ALA A 306
GLN A 288
THR A 285
 None
 1.37A 5n0wB-4a5wA:
undetectable		 5n0wB-4a5wA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		4 / 7 ASP A1289
PHE A1284
GLY A1243
GLY A1281
 None
 0.85A 5n9xA-4a5wA:
undetectable		 5n9xA-4a5wA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		5 / 12 LEU A1259
VAL A1304
SER A1301
VAL A 991
THR A1290
 None
 1.46A 5v1tA-4a5wA:
undetectable		 5v1tA-4a5wA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		5 / 12 ALA A1560
ILE A1645
VAL A1563
TYR A1577
PHE A1600
 None
 1.20A 5vlmB-4a5wA:
2.5		 5vlmB-4a5wA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		5 / 12 ALA A1560
ILE A1645
VAL A1563
TYR A1577
PHE A1600
 None
 1.33A 5vlmE-4a5wA:
2.8		 5vlmE-4a5wA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_1
(OXAC)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		4 / 5 TYR A 582
HIS A 574
ASP A 578
ARG A 783
 None
 1.31A 5w7pA-4a5wA:
0.0		 5w7pA-4a5wA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		4 / 6 LEU A 602
VAL A 600
LEU A 571
VAL A 780
 None
 0.89A 5x7zA-4a5wA:
undetectable		 5x7zA-4a5wA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		5 / 12 LEU A1581
ILE A1584
LYS A1628
GLY A1588
PHE A1633
 None
 1.22A 6a7pA-4a5wA:
2.5		 6a7pA-4a5wA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		4 / 4 LEU A 379
ASP A 377
GLN A 381
VAL A 612
 None
 1.49A 6bzoF-4a5wA:
3.1		 6bzoF-4a5wA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		4 / 6 ILE A1264
TYR A1300
VAL A 984
ARG A1308
 None
 1.15A 6f6jA-4a5wA:
undetectable		 6f6jA-4a5wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4a5w COMPLEMENT C5
(Homo
sapiens) 		4 / 6 ILE A1461
LEU A1462
TYR A1496
THR A1506
 None
 1.05A 6nmfN-4a5wA:
undetectable
6nmfW-4a5wA:
undetectable		 6nmfN-4a5wA:
15.08
6nmfW-4a5wA:
3.59