SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a5z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4a5z MIT
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 9 ILE A 205
ASP A 243
GLY A 202
PHE A 199
ASN A 201
 None
 1.29A 1i00B-4a5zA:
undetectable		 1i00B-4a5zA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 4a5z MIT
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 ILE A  94
ARG A 209
PRO A 217
SER A 222
 None
 1.40A 2qd3B-4a5zA:
undetectable		 2qd3B-4a5zA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 4a5z MIT
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 5 PRO A 123
ILE A 125
ARG A 126
ASP A 212
 None
 1.37A 2rhmB-4a5zA:
undetectable		 2rhmB-4a5zA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 4a5z MIT
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 5 PRO A 123
ILE A 125
ARG A 126
ASP A 212
 None
 1.37A 2rhmD-4a5zA:
undetectable		 2rhmD-4a5zA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4a5z MIT
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 9 ILE A 205
ASP A 243
GLY A 202
PHE A 199
ASN A 201
 None
 1.29A 4eb4C-4a5zA:
undetectable		 4eb4C-4a5zA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4a5z MIT
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 ILE A 205
ASP A 243
GLY A 202
PHE A 199
ASN A 201
 None
 1.30A 4eb4D-4a5zA:
undetectable		 4eb4D-4a5zA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 4a5z MIT
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 HIS A  88
LYS A  87
PHE A 241
 None
 1.39A 5klaA-4a5zA:
undetectable		 5klaA-4a5zA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4a5z MIT
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 9 ILE A 205
ASP A 243
GLY A 202
PHE A 199
ASN A 201
 None
 1.32A 5x66C-4a5zA:
undetectable		 5x66C-4a5zA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4a5z MIT
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 ILE A 205
ASP A 243
GLY A 202
PHE A 199
ASN A 201
 None
 1.32A 5x66D-4a5zA:
undetectable		 5x66D-4a5zA:
19.72