SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a63'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4a63 APOPTOSIS
STIMULATING OF P53
PROTEIN 2
(Homo
sapiens) 		5 / 9 ILE B1086
GLY B1055
GLY B1115
PHE B1019
ARG B1111
 None
 1.07A 2y7wA-4a63B:
undetectable		 2y7wA-4a63B:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 4a63 APOPTOSIS
STIMULATING OF P53
PROTEIN 2
(Homo
sapiens) 		4 / 7 ALA B1029
VAL B1050
VAL B1018
LEU B 996
 None
 0.85A 3o14A-4a63B:
undetectable		 3o14A-4a63B:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4a63 APOPTOSIS
STIMULATING OF P53
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE B1062
GLY B1115
VAL B1018
MET B1084
VAL B1109
 None
 1.00A 5n0rA-4a63B:
undetectable		 5n0rA-4a63B:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4a63 APOPTOSIS
STIMULATING OF P53
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE B1062
GLY B1115
VAL B1018
MET B1084
VAL B1109
 None
 0.97A 5n0sA-4a63B:
undetectable		 5n0sA-4a63B:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4a63 APOPTOSIS
STIMULATING OF P53
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE B1062
GLY B1115
VAL B1018
MET B1084
VAL B1109
 None
 1.00A 5n0tA-4a63B:
undetectable		 5n0tA-4a63B:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4a63 APOPTOSIS
STIMULATING OF P53
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE B1062
GLY B1115
VAL B1018
MET B1084
VAL B1109
 None
 1.00A 5n0wA-4a63B:
undetectable		 5n0wA-4a63B:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4a63 APOPTOSIS
STIMULATING OF P53
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE B1062
GLY B1115
VAL B1018
MET B1084
VAL B1109
 None
 0.98A 5n0wB-4a63B:
undetectable		 5n0wB-4a63B:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4a63 APOPTOSIS
STIMULATING OF P53
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE B1062
GLY B1115
VAL B1018
MET B1084
VAL B1109
 None
 0.96A 5n4iA-4a63B:
undetectable		 5n4iA-4a63B:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4a63 APOPTOSIS
STIMULATING OF P53
PROTEIN 2
(Homo
sapiens) 		5 / 12 PHE B1010
SER B1014
ALA B1017
ALA B1016
GLY B1015
 None
 1.23A 5tzoA-4a63B:
undetectable		 5tzoA-4a63B:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4a63 APOPTOSIS
STIMULATING OF P53
PROTEIN 2
(Homo
sapiens) 		5 / 12 SER B1014
VAL B1012
ALA B1017
ALA B1016
GLY B1015
 None
 1.37A 5tzoA-4a63B:
undetectable		 5tzoA-4a63B:
17.84