SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a64'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4a64 CULLIN-4B
(Homo
sapiens) 		4 / 7 LEU A 262
SER A 264
PHE A 267
LEU A 268
 None
 0.61A 1j8uA-4a64A:
undetectable		 1j8uA-4a64A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4a64 CULLIN-4B
(Homo
sapiens) 		4 / 7 MET A 356
ILE A 318
GLY A 310
TRP A 307
 None
 1.16A 2pnjB-4a64A:
undetectable		 2pnjB-4a64A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 4a64 CULLIN-4B
(Homo
sapiens) 		3 / 3 GLU A 404
HIS A 398
HIS A 397
 None
 0.92A 3co4A-4a64A:
undetectable		 3co4A-4a64A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4a64 CULLIN-4B
(Homo
sapiens) 		4 / 6 THR A 375
SER A 421
LEU A 422
THR A 425
 None
 0.76A 3deuB-4a64A:
undetectable		 3deuB-4a64A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4a64 CULLIN-4B
(Homo
sapiens) 		4 / 6 TYR A 239
MET A 282
ILE A 306
ASP A 293
 None
EDO  A1537 (-4.2A)
None
None
 1.26A 5iwuA-4a64A:
undetectable		 5iwuA-4a64A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 4a64 CULLIN-4B
(Homo
sapiens) 		4 / 8 GLY A 467
LEU A 431
GLY A 432
LEU A 435
 None
 0.73A 6mdqA-4a64A:
undetectable		 6mdqA-4a64A:
16.00