SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a6q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 4a6q HISTONE DEACETYLASE
COMPLEX SUBUNIT
SAP18
(Mus
musculus) 		4 / 5 PRO A  19
ILE A  20
ARG A  22
ASP A  21
 None
 1.34A 2rhmB-4a6qA:
undetectable		 2rhmB-4a6qA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 4a6q HISTONE DEACETYLASE
COMPLEX SUBUNIT
SAP18
(Mus
musculus) 		5 / 10 LEU A  30
LEU A 122
LEU A  66
LYS A  67
LEU A 133
 None
 1.14A 2xn6A-4a6qA:
undetectable
2xn6B-4a6qA:
undetectable		 2xn6A-4a6qA:
16.24
2xn6B-4a6qA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4a6q HISTONE DEACETYLASE
COMPLEX SUBUNIT
SAP18
(Mus
musculus) 		5 / 9 MET A  62
ALA A  64
LEU A 133
ILE A 106
THR A  60
 None
 1.22A 3fl9H-4a6qA:
undetectable		 3fl9H-4a6qA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4a6q HISTONE DEACETYLASE
COMPLEX SUBUNIT
SAP18
(Mus
musculus) 		4 / 6 ASP A 134
HIS A  41
ILE A 137
TYR A  77
 None
None
None
IPA  A1144 (-3.8A)
 1.25A 5ih0A-4a6qA:
undetectable		 5ih0A-4a6qA:
20.14