SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a6u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		5 / 11 LEU A 339
ALA A  57
VAL A 336
LEU A 103
LEU A 290
 None
 1.11A 1rlbF-4a6uA:
undetectable		 1rlbF-4a6uA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		4 / 5 VAL A 202
GLY A 201
VAL A 203
TRP A 188
 None
 1.10A 1tkqB-4a6uA:
undetectable		 1tkqB-4a6uA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		4 / 5 PRO A 354
ILE A 352
ARG A 432
ASP A 351
 None
 1.35A 2rhmB-4a6uA:
undetectable		 2rhmB-4a6uA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		4 / 5 VAL A 257
VAL A 224
GLN A 229
PHE A 272
 None
 1.33A 3bjwB-4a6uA:
0.3		 3bjwB-4a6uA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		5 / 12 SER A 291
GLY A 293
GLY A 120
GLY A 298
GLY A 289
 None
SCN  A 602 ( 4.8A)
None
None
None
 0.92A 3gczA-4a6uA:
undetectable		 3gczA-4a6uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		5 / 12 TYR A 116
ALA A 286
GLY A 298
GLY A 289
SER A 291
 None
 1.27A 3ou7D-4a6uA:
undetectable		 3ou7D-4a6uA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		4 / 6 ARG A 149
VAL A 257
PHE A 223
GLU A 246
 None
 1.37A 3ufrA-4a6uA:
undetectable
3ufrB-4a6uA:
undetectable		 3ufrA-4a6uA:
21.59
3ufrB-4a6uA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		6 / 12 TYR A 116
PHE A 301
LEU A 102
LEU A 103
ALA A 338
ALA A 337
 None
 1.50A 3vw7A-4a6uA:
undetectable		 3vw7A-4a6uA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		4 / 7 ARG A 149
VAL A 257
PHE A 223
GLU A 246
 None
 1.47A 4caoA-4a6uA:
undetectable
4caoB-4a6uA:
undetectable		 4caoA-4a6uA:
21.59
4caoB-4a6uA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		4 / 5 ALA A 181
ILE A 212
LEU A 208
LYS A 211
 None
 1.11A 4g19A-4a6uA:
undetectable		 4g19A-4a6uA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		5 / 11 ALA A 334
ALA A 338
ALA A 337
VAL A 106
LEU A 103
 None
 1.10A 4j6cA-4a6uA:
undetectable		 4j6cA-4a6uA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		5 / 10 ALA A 334
ALA A 338
ALA A 337
VAL A 106
LEU A 103
 None
 1.09A 4j6cB-4a6uA:
undetectable		 4j6cB-4a6uA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		5 / 12 ALA A 334
ALA A 338
ALA A 337
VAL A 106
LEU A 103
 None
 1.06A 4j6dA-4a6uA:
undetectable		 4j6dA-4a6uA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		5 / 12 ALA A 334
ALA A 338
ALA A 337
VAL A 106
LEU A 103
 None
 1.06A 4j6dB-4a6uA:
undetectable		 4j6dB-4a6uA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		5 / 12 ALA A 334
ALA A 338
ALA A 337
VAL A 106
LEU A 103
 None
 1.06A 4jbtA-4a6uA:
undetectable		 4jbtA-4a6uA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		5 / 11 ALA A 334
ALA A 338
ALA A 337
VAL A 106
LEU A 103
 None
 1.06A 4jbtB-4a6uA:
undetectable		 4jbtB-4a6uA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		3 / 3 SER A 424
MET A 415
ASP A 372
 None
 0.85A 4mm4B-4a6uA:
undetectable		 4mm4B-4a6uA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		4 / 6 GLU A 434
ASP A  54
ASN A  63
ARG A 267
 None
 1.33A 4ntxA-4a6uA:
undetectable
4ntxC-4a6uA:
undetectable		 4ntxA-4a6uA:
22.16
4ntxC-4a6uA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		5 / 12 ALA A 287
GLY A 120
SER A 121
ILE A 262
GLY A 264
 None
 1.23A 4obwA-4a6uA:
undetectable		 4obwA-4a6uA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		4 / 4 VAL A 379
GLY A 375
ARG A 374
VAL A 423
 None
 1.07A 5d4nA-4a6uA:
0.0
5d4nB-4a6uA:
0.6		 5d4nA-4a6uA:
16.55
5d4nB-4a6uA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		4 / 5 VAL A 423
VAL A 379
GLY A 375
ARG A 374
 None
 1.10A 5d4nA-4a6uA:
undetectable
5d4nC-4a6uA:
undetectable		 5d4nA-4a6uA:
16.55
5d4nC-4a6uA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		5 / 12 SER A 291
GLY A 293
GLY A 120
GLY A 298
GLY A 289
 None
SCN  A 602 ( 4.8A)
None
None
None
 0.96A 5ekxA-4a6uA:
undetectable		 5ekxA-4a6uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		5 / 12 GLY A 266
LEU A 103
LEU A  99
ASN A 335
LEU A 290
 None
 1.06A 5nfjB-4a6uA:
undetectable		 5nfjB-4a6uA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		4 / 7 PHE A 223
GLU A 246
ARG A 149
VAL A 257
 None
 1.47A 5vusA-4a6uA:
0.8
5vusB-4a6uA:
undetectable		 5vusA-4a6uA:
21.59
5vusB-4a6uA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		4 / 7 ARG A 149
VAL A 257
PHE A 223
GLU A 246
 None
 1.45A 5vuyA-4a6uA:
0.9
5vuyB-4a6uA:
undetectable		 5vuyA-4a6uA:
21.61
5vuyB-4a6uA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		4 / 6 GLN A 380
VAL A 236
LEU A 439
ARG A 366
 None
 1.14A 6brdB-4a6uA:
undetectable		 6brdB-4a6uA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		4 / 7 ILE A 248
VAL A 254
ILE A 147
THR A 145
 None
 0.87A 6cduF-4a6uA:
undetectable
6cduG-4a6uA:
undetectable		 6cduF-4a6uA:
21.01
6cduG-4a6uA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		4 / 8 ILE A 248
VAL A 254
ILE A 147
THR A 145
 None
 0.89A 6cduG-4a6uA:
undetectable
6cduH-4a6uA:
undetectable		 6cduG-4a6uA:
21.01
6cduH-4a6uA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 4a6u OMEGA TRANSAMINASE
(Chromobacterium
violaceum) 		4 / 7 GLY A 293
TYR A 294
GLU A  40
GLY A  67
 SCN  A 602 ( 4.8A)
None
None
SCN  A 601 (-3.5A)
 0.88A 6n7fA-4a6uA:
undetectable		 6n7fA-4a6uA:
10.96