SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a73'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 VAL A  27
GLY A  28
ASP A  53
TYR A  85
ALA A  98
 None
 0.67A 1cetA-4a73A:
38.4		 1cetA-4a73A:
33.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 ALA A 133
LEU A 135
LEU A 136
ILE A  26
LEU A  88
 None
 1.45A 1ereA-4a73A:
undetectable		 1ereA-4a73A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 ALA A 133
LEU A 135
LEU A 136
ILE A  26
LEU A  88
 None
 1.45A 1ereB-4a73A:
undetectable		 1ereB-4a73A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 ALA A 133
LEU A 135
LEU A 136
ILE A  26
LEU A  88
 None
 1.44A 1ereD-4a73A:
undetectable		 1ereD-4a73A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A  25
LEU A  88
VAL A 123
LEU A  96
ALA A  97
 None
 1.03A 1gseB-4a73A:
undetectable		 1gseB-4a73A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 VAL A 148
ASN A 116
GLY A  33
THR A 139
ALA A 138
 None
 1.13A 1jg4A-4a73A:
3.6		 1jg4A-4a73A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 LEU A  58
GLY A  30
GLY A  33
VAL A  95
LEU A  51
 None
 1.15A 1mx1A-4a73A:
2.2		 1mx1A-4a73A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 ALA A 133
LEU A 135
LEU A 136
ILE A  26
LEU A  88
 None
 1.45A 1qkuA-4a73A:
undetectable		 1qkuA-4a73A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 ALA A 133
LEU A 135
LEU A 136
ILE A  26
LEU A  88
 None
 1.45A 1qkuB-4a73A:
undetectable		 1qkuB-4a73A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 ALA A 133
LEU A 135
LEU A 136
ILE A  26
LEU A  88
 None
 1.45A 1qkuC-4a73A:
undetectable		 1qkuC-4a73A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QYX_A_ASDA500_1
(ESTRADIOL 17
BETA-DEHYDROGENASE 1)		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 VAL A 202
LEU A 192
SER A 318
GLU A 279
VAL A 278
 None
 1.25A 1qyxA-4a73A:
7.0		 1qyxA-4a73A:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 VAL A 298
LEU A 293
THR A 169
GLY A 162
LEU A 315
 None
 1.13A 2cbrA-4a73A:
undetectable		 2cbrA-4a73A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 THR A 146
THR A 139
ALA A  97
SER A 272
GLY A 164
 None
 1.14A 2f162-4a73A:
undetectable		 2f162-4a73A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 THR A 146
THR A 139
ALA A  97
SER A 272
GLY A 164
 None
 1.13A 2f16N-4a73A:
undetectable		 2f16N-4a73A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 TYR A 190
GLY A 267
THR A 270
GLU A 265
 None
 1.05A 3fpjA-4a73A:
4.0		 3fpjA-4a73A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 THR A 146
THR A 139
ALA A  97
SER A 272
GLY A 164
 None
 1.08A 3mg0N-4a73A:
undetectable		 3mg0N-4a73A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		6 / 12 ALA A  37
THR A  36
ALA A  35
VAL A  78
ALA A  46
ALA A  41
 None
 1.32A 3mg0Y-4a73A:
undetectable
3mg0Z-4a73A:
undetectable		 3mg0Y-4a73A:
19.87
3mg0Z-4a73A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 TYR A  85
ALA A  98
LEU A  96
LEU A 128
ALA A 131
 None
 1.10A 3ozvB-4a73A:
2.7		 3ozvB-4a73A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 THR A 146
ALA A 138
THR A 139
ALA A  97
VAL A 271
 None
 1.19A 4qvnK-4a73A:
undetectable
4qvnL-4a73A:
undetectable		 4qvnK-4a73A:
19.87
4qvnL-4a73A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 THR A 146
ALA A 138
THR A 139
ALA A  97
VAL A 271
 None
 1.19A 4qvnY-4a73A:
undetectable
4qvnZ-4a73A:
undetectable		 4qvnY-4a73A:
19.87
4qvnZ-4a73A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 VAL A 271
THR A 270
VAL A 258
ALA A 255
LEU A 257
 None
 0.98A 5kocA-4a73A:
3.8		 5kocA-4a73A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 GLY A  90
ALA A  91
VAL A 258
LEU A 262
 None
 0.85A 6dwnB-4a73A:
undetectable		 6dwnB-4a73A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_2
(-)		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 GLN A 147
THR A 146
THR A 165
LEU A 289
 None
 1.44A 6f3mB-4a73A:
5.3		 6f3mB-4a73A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 4a73 L-LACTATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 THR A 146
VAL A 285
THR A 165
ILE A 166
VAL A 271
 None
 1.40A 6hcoA-4a73A:
undetectable
6hcoB-4a73A:
undetectable		 6hcoA-4a73A:
18.88
6hcoB-4a73A:
18.88