SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a7k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 8 SER A 432
SER A 402
HIS A 401
PHE A 456
 None
 1.30A 1eqbA-4a7kA:
undetectable
1eqbB-4a7kA:
undetectable		 1eqbA-4a7kA:
18.65
1eqbB-4a7kA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 8 PHE A 456
SER A 432
SER A 402
HIS A 401
 None
 1.31A 1eqbA-4a7kA:
undetectable
1eqbB-4a7kA:
undetectable		 1eqbA-4a7kA:
18.65
1eqbB-4a7kA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 8 SER A 432
SER A 402
HIS A 401
PHE A 456
 None
 1.31A 1eqbC-4a7kA:
undetectable
1eqbD-4a7kA:
undetectable		 1eqbC-4a7kA:
18.65
1eqbD-4a7kA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 8 PHE A 456
SER A 432
SER A 402
HIS A 401
 None
 1.31A 1eqbC-4a7kA:
undetectable
1eqbD-4a7kA:
undetectable		 1eqbC-4a7kA:
18.65
1eqbD-4a7kA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 6 HIS A 861
LEU A 864
LEU A 855
PRO A 856
 None
 1.15A 1hz4A-4a7kA:
undetectable		 1hz4A-4a7kA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 6 ALA A 893
LEU A 891
SER A 867
THR A 852
 None
 0.92A 1ictB-4a7kA:
undetectable		 1ictB-4a7kA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 7 ALA A 710
PHE A 629
SER A 626
TRP A 711
 None
 1.21A 1lqtA-4a7kA:
undetectable		 1lqtA-4a7kA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 7 ALA A 710
PHE A 629
SER A 626
TRP A 711
 None
 1.22A 1lquA-4a7kA:
undetectable		 1lquA-4a7kA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		3 / 3 GLU A 639
HIS A 709
HIS A 632
 ZN  A 952 ( 2.4A)
ZN  A 952 (-3.3A)
ZN  A 952 (-3.3A)
 0.62A 1oe2A-4a7kA:
undetectable		 1oe2A-4a7kA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 8 ALA A 276
GLN A 338
ILE A 395
ILE A 409
 None
 0.91A 1rg9B-4a7kA:
undetectable		 1rg9B-4a7kA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 11 GLY A 238
GLY A 271
ILE A 288
SER A 300
ALA A 275
 None
 0.97A 1x7pA-4a7kA:
undetectable
1x7pB-4a7kA:
undetectable		 1x7pA-4a7kA:
16.72
1x7pB-4a7kA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 8 HIS A 632
GLU A 639
HIS A 709
ALA A 728
 ZN  A 952 (-3.3A)
ZN  A 952 ( 2.4A)
ZN  A 952 (-3.3A)
GOL  A1904 (-3.4A)
 0.90A 2bnnA-4a7kA:
6.6
2bnnB-4a7kA:
6.3		 2bnnA-4a7kA:
12.67
2bnnB-4a7kA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H9T_H_SVRH301_1
(THROMBIN)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 11 PRO A  72
TRP A  83
VAL A  27
GLN A  28
GLY A  34
 None
 1.50A 2h9tH-4a7kA:
undetectable		 2h9tH-4a7kA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 12 PHE A 462
ALA A 494
ALA A 614
ALA A 451
GLY A 495
 None
 1.06A 2igtA-4a7kA:
undetectable		 2igtA-4a7kA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 12 PHE A 462
ALA A 494
ALA A 614
ALA A 451
GLY A 495
 None
 1.03A 2igtB-4a7kA:
undetectable		 2igtB-4a7kA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 12 PHE A 462
ALA A 494
ALA A 614
ALA A 451
GLY A 495
 None
 1.03A 2igtC-4a7kA:
undetectable		 2igtC-4a7kA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 5 SER A 335
ARG A 366
PRO A 327
GLY A 326
 None
 1.32A 2y7kB-4a7kA:
undetectable		 2y7kB-4a7kA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 6 ALA A 893
LEU A 891
SER A 867
THR A 852
 None
 0.86A 3cfqA-4a7kA:
undetectable		 3cfqA-4a7kA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 6 ALA A 893
LEU A 891
SER A 867
THR A 852
 None
 1.04A 3d2tB-4a7kA:
undetectable		 3d2tB-4a7kA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 12 GLY A 393
VAL A 340
ILE A 395
HIS A 155
LEU A  57
 None
 1.29A 3g9eA-4a7kA:
undetectable		 3g9eA-4a7kA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		3 / 3 GLU A 518
GLU A 683
TRP A 499
 None
 1.35A 3hrdA-4a7kA:
undetectable
3hrdE-4a7kA:
undetectable
3hrdF-4a7kA:
undetectable		 3hrdA-4a7kA:
19.67
3hrdE-4a7kA:
19.67
3hrdF-4a7kA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 4 PRO A  94
TYR A  55
GLY A  58
THR A  59
 None
 1.41A 3ib0A-4a7kA:
undetectable		 3ib0A-4a7kA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 12 ASP A 283
ARG A 279
ALA A 315
GLU A 228
ARG A 314
 None
 1.24A 3k37B-4a7kA:
11.2		 3k37B-4a7kA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_B_BCZB1001_0
(NEURAMINIDASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 12 ASP A 283
ARG A 279
ALA A 315
GLU A 228
ARG A 314
 None
 1.27A 3k39B-4a7kA:
10.5		 3k39B-4a7kA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 12 ASP A 283
ARG A 279
ALA A 315
GLU A 228
ARG A 314
 None
 1.27A 3k39C-4a7kA:
3.9		 3k39C-4a7kA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 12 ASP A 283
ARG A 279
ALA A 315
GLU A 228
ARG A 314
 None
 1.28A 3k39D-4a7kA:
7.3		 3k39D-4a7kA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 12 ASP A 283
ARG A 279
ALA A 315
GLU A 228
ARG A 314
 None
 1.28A 3k39I-4a7kA:
6.6		 3k39I-4a7kA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 12 ASP A 283
ARG A 279
ALA A 315
GLU A 228
ARG A 314
 None
 1.28A 3k39J-4a7kA:
3.2		 3k39J-4a7kA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 12 ASP A 283
ARG A 279
ALA A 315
GLU A 228
ARG A 314
 None
 1.27A 3k39K-4a7kA:
5.2		 3k39K-4a7kA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 12 ASP A 283
ARG A 279
ALA A 315
GLU A 228
ARG A 314
 None
 1.27A 3k39L-4a7kA:
3.0		 3k39L-4a7kA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 6 ILE A 219
VAL A 217
LEU A 236
LEU A 245
 None
 0.79A 3kp6A-4a7kA:
undetectable
3kp6B-4a7kA:
undetectable		 3kp6A-4a7kA:
11.10
3kp6B-4a7kA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 12 TYR A 269
GLY A 238
ALA A 272
PHE A 294
ASP A 240
 None
 1.37A 3nmuA-4a7kA:
undetectable
3nmuF-4a7kA:
undetectable		 3nmuA-4a7kA:
17.33
3nmuF-4a7kA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 7 ALA A 779
VAL A 826
VAL A 777
LEU A 764
 None
 0.84A 3o14A-4a7kA:
undetectable		 3o14A-4a7kA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 5 VAL A 407
ILE A 395
MET A  97
ARG A 279
 None
 1.45A 3oezA-4a7kA:
undetectable		 3oezA-4a7kA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 5 VAL A 407
ILE A 395
MET A  97
ARG A 279
 None
 1.45A 3pyyB-4a7kA:
undetectable		 3pyyB-4a7kA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 10 ALA A 100
VAL A 170
ILE A 111
ALA A 193
VAL A 168
 None
 0.97A 3t3cB-4a7kA:
undetectable		 3t3cB-4a7kA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		3 / 3 SER A 895
ASP A 782
ASP A 878
 None
 0.79A 3uj7A-4a7kA:
undetectable		 3uj7A-4a7kA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 12 ASP A 283
ARG A 279
ALA A 315
GLU A 228
ARG A 314
 None
 1.27A 4cpnB-4a7kA:
2.9		 4cpnB-4a7kA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 6 THR A 333
TYR A 419
HIS A 337
HIS A 215
 None
None
ZN  A 950 (-3.3A)
ZN  A 950 (-3.3A)
 1.37A 4df2A-4a7kA:
undetectable		 4df2A-4a7kA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 12 GLU A 683
GLU A 518
GLY A 685
PHE A 737
VAL A 490
 None
 1.43A 4ffwB-4a7kA:
6.2		 4ffwB-4a7kA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 12 GLN A 790
LEU A 781
ILE A 880
VAL A 814
LEU A 764
 None
 0.92A 4gc9A-4a7kA:
undetectable		 4gc9A-4a7kA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 6 ALA A 893
LEU A 891
SER A 867
THR A 852
 None
 0.93A 4i89A-4a7kA:
undetectable		 4i89A-4a7kA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 11 ILE A 395
ALA A 392
GLY A 368
GLY A 334
ASN A 297
 None
 1.31A 4jdsC-4a7kA:
undetectable		 4jdsC-4a7kA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 5 GLY A 273
SER A 274
ALA A 291
PHE A 294
 None
 0.99A 4m93B-4a7kA:
undetectable
4m93C-4a7kA:
undetectable		 4m93B-4a7kA:
13.24
4m93C-4a7kA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 12 GLY A 271
GLY A 241
GLY A 258
LEU A 213
ALA A 293
 None
 0.94A 4uciA-4a7kA:
undetectable		 4uciA-4a7kA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 12 GLY A 271
GLY A 241
GLY A 258
LEU A 213
ALA A 293
 None
 0.94A 4uciB-4a7kA:
undetectable		 4uciB-4a7kA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		3 / 3 SER A 391
ALA A 355
VAL A 354
 None
 0.50A 4x1iA-4a7kA:
undetectable		 4x1iA-4a7kA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 5 LEU A 687
GLU A 674
LEU A 712
HIS A 630
 None
None
None
ZN  A 952 ( 3.3A)
 1.24A 4xi3B-4a7kA:
undetectable		 4xi3B-4a7kA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 11 PHE A  93
VAL A 416
ASP A  33
TYR A 414
GLY A  58
 None
 1.18A 4xnxA-4a7kA:
undetectable		 4xnxA-4a7kA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 11 VAL A 416
ASP A  33
TYR A 414
TYR A  35
GLY A  58
 None
 1.06A 4xnxA-4a7kA:
undetectable		 4xnxA-4a7kA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 6 ALA A 893
LEU A 891
SER A 867
THR A 852
 None
 0.92A 5bojA-4a7kA:
undetectable		 5bojA-4a7kA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 7 ARG A 319
GLY A 271
THR A 298
GLU A 292
 None
 0.80A 5bs8A-4a7kA:
undetectable
5bs8C-4a7kA:
undetectable
5bs8D-4a7kA:
undetectable		 5bs8A-4a7kA:
20.49
5bs8C-4a7kA:
20.49
5bs8D-4a7kA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 7 ARG A 319
GLY A 271
THR A 298
GLU A 292
 None
 0.79A 5bs8A-4a7kA:
undetectable
5bs8B-4a7kA:
undetectable
5bs8C-4a7kA:
undetectable		 5bs8A-4a7kA:
20.49
5bs8B-4a7kA:
16.46
5bs8C-4a7kA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 7 ARG A 319
GLY A 271
THR A 298
GLU A 292
 None
 0.80A 5btaA-4a7kA:
undetectable
5btaC-4a7kA:
undetectable
5btaD-4a7kA:
undetectable		 5btaA-4a7kA:
20.49
5btaC-4a7kA:
20.49
5btaD-4a7kA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 6 ARG A 319
GLY A 271
THR A 298
GLU A 292
 None
 0.80A 5btaA-4a7kA:
undetectable
5btaB-4a7kA:
undetectable
5btaC-4a7kA:
undetectable		 5btaA-4a7kA:
20.49
5btaB-4a7kA:
16.46
5btaC-4a7kA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 6 ARG A 319
GLY A 271
THR A 298
GLU A 292
 None
 0.87A 5btcA-4a7kA:
undetectable
5btcC-4a7kA:
undetectable
5btcD-4a7kA:
undetectable		 5btcA-4a7kA:
20.49
5btcC-4a7kA:
20.49
5btcD-4a7kA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 6 ARG A 319
GLY A 271
THR A 298
GLU A 292
 None
 0.86A 5btcA-4a7kA:
undetectable
5btcB-4a7kA:
undetectable
5btcC-4a7kA:
undetectable		 5btcA-4a7kA:
20.49
5btcB-4a7kA:
16.46
5btcC-4a7kA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 7 ARG A 319
GLY A 271
THR A 298
GLU A 292
 None
 0.82A 5btdA-4a7kA:
undetectable
5btdB-4a7kA:
undetectable
5btdC-4a7kA:
undetectable		 5btdA-4a7kA:
20.49
5btdB-4a7kA:
16.46
5btdC-4a7kA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 7 ARG A 319
GLY A 271
THR A 298
GLU A 292
 None
 0.83A 5btdA-4a7kA:
undetectable
5btdC-4a7kA:
undetectable
5btdD-4a7kA:
undetectable		 5btdA-4a7kA:
20.49
5btdC-4a7kA:
20.49
5btdD-4a7kA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 7 ARG A 319
GLY A 271
THR A 298
GLU A 292
 None
 0.85A 5btfA-4a7kA:
undetectable
5btfB-4a7kA:
undetectable
5btfC-4a7kA:
undetectable		 5btfA-4a7kA:
20.49
5btfB-4a7kA:
16.46
5btfC-4a7kA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 6 ARG A 319
GLY A 271
THR A 298
GLU A 292
 None
 0.77A 5btgA-4a7kA:
undetectable
5btgB-4a7kA:
undetectable
5btgC-4a7kA:
undetectable		 5btgA-4a7kA:
20.49
5btgB-4a7kA:
16.46
5btgC-4a7kA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 7 ARG A 319
GLY A 271
THR A 298
GLU A 292
 None
 0.73A 5btgA-4a7kA:
undetectable
5btgC-4a7kA:
undetectable
5btgD-4a7kA:
undetectable		 5btgA-4a7kA:
20.49
5btgC-4a7kA:
20.49
5btgD-4a7kA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 5 ALA A 100
TYR A  99
PRO A 221
GLY A 286
 None
 1.00A 5eslA-4a7kA:
undetectable		 5eslA-4a7kA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		3 / 3 SER A 391
ALA A 355
VAL A 354
 None
 0.55A 5eypA-4a7kA:
undetectable		 5eypA-4a7kA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 6 LEU A 328
TRP A 370
GLN A 365
MET A 356
 None
 1.31A 5h8tA-4a7kA:
2.3		 5h8tA-4a7kA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		3 / 3 VAL A 429
ARG A  43
PRO A  41
 None
None
GOL  A1900 (-4.3A)
 0.84A 5koxA-4a7kA:
undetectable		 5koxA-4a7kA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 6 ALA A 893
LEU A 891
SER A 867
THR A 852
 None
 0.95A 5l4iA-4a7kA:
undetectable		 5l4iA-4a7kA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 5 ALA A  39
VAL A  37
PHE A 400
ILE A 427
 None
 0.94A 5of1A-4a7kA:
undetectable		 5of1A-4a7kA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 5 ALA A  39
VAL A  37
PHE A 400
ILE A 427
 None
 0.90A 5of1B-4a7kA:
undetectable		 5of1B-4a7kA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		5 / 12 VAL A 474
ALA A 642
PHE A 729
LEU A 613
VAL A 603
 None
 1.27A 5tudD-4a7kA:
undetectable		 5tudD-4a7kA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		3 / 3 HIS A 630
HIS A 709
HIS A 632
 ZN  A 952 ( 3.3A)
ZN  A 952 (-3.3A)
ZN  A 952 (-3.3A)
 0.48A 5zrdA-4a7kA:
undetectable		 5zrdA-4a7kA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 5 HIS A 337
HIS A 215
PHE A 294
HIS A 295
 ZN  A 950 (-3.3A)
ZN  A 950 (-3.3A)
None
ZN  A 950 (-3.3A)
 0.84A 5zrdB-4a7kA:
undetectable		 5zrdB-4a7kA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 6 GLY A 128
ASP A 114
SER A 131
ARG A 129
 None
 1.18A 6dwdA-4a7kA:
undetectable
6dwdC-4a7kA:
undetectable		 6dwdA-4a7kA:
19.76
6dwdC-4a7kA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4a7k ALDOS-2-ULOSE
DEHYDRATASE
(Phanerochaete
chrysosporium) 		4 / 8 TYR A 284
VAL A 277
PRO A 221
ILE A 219
 None
 1.09A 6hzpA-4a7kA:
undetectable		 6hzpA-4a7kA:
18.79