SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a7l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 4a7l MYOSIN IE HEAVY
CHAIN
(Dictyostelium
discoideum) 		4 / 7 MET C 166
SER C 139
SER C 133
ILE C 132
 None
 1.06A 1fxhA-4a7lC:
undetectable
1fxhB-4a7lC:
undetectable		 1fxhA-4a7lC:
14.29
1fxhB-4a7lC:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4a7l MYOSIN IE HEAVY
CHAIN
(Dictyostelium
discoideum) 		5 / 12 ASN C 373
SER C 139
LEU C 143
MET C 164
LEU C 136
 None
 1.50A 1ya3B-4a7lC:
undetectable		 1ya3B-4a7lC:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 4a7l TROPOMYOSIN 1 ALPHA
(Oryctolagus
cuniculus) 		4 / 6 LEU B 148
GLN B 144
GLU B 142
ILE B 143
 None
 1.11A 2fcnA-4a7lB:
undetectable
2fcnB-4a7lB:
undetectable		 2fcnA-4a7lB:
20.74
2fcnB-4a7lB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 4a7l MYOSIN IE HEAVY
CHAIN
(Dictyostelium
discoideum) 		3 / 3 GLY C 529
ASP C 530
SER C 533
 None
 0.68A 2qhfA-4a7lC:
undetectable		 2qhfA-4a7lC:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 4a7l MYOSIN IE HEAVY
CHAIN
(Dictyostelium
discoideum) 		4 / 8 TYR C 630
ILE C 670
THR C 656
ILE C 659
 None
 0.80A 3p4wC-4a7lC:
1.1		 3p4wC-4a7lC:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4a7l MYOSIN IE HEAVY
CHAIN
(Dictyostelium
discoideum) 		5 / 12 LEU C 577
LEU C 413
LEU C 410
CYH C 406
ILE C  98
 None
 1.13A 4a7aB-4a7lC:
undetectable		 4a7aB-4a7lC:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4a7l MYOSIN IE HEAVY
CHAIN
(Dictyostelium
discoideum) 		4 / 6 PHE C 146
ALA C 252
LEU C 256
THR C 255
 None
 0.94A 4dtzA-4a7lC:
undetectable		 4dtzA-4a7lC:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4a7l MYOSIN IE HEAVY
CHAIN
(Dictyostelium
discoideum) 		4 / 6 PHE C 146
ALA C 252
LEU C 256
THR C 255
 None
 0.94A 4dtzB-4a7lC:
undetectable		 4dtzB-4a7lC:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4a7l MYOSIN IE HEAVY
CHAIN
(Dictyostelium
discoideum) 		4 / 7 PHE C 146
ALA C 252
LEU C 256
THR C 255
 None
 0.90A 4du2B-4a7lC:
undetectable		 4du2B-4a7lC:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 4a7l TROPOMYOSIN 1 ALPHA
(Oryctolagus
cuniculus) 		3 / 3 LYS B 152
LEU B 148
ALA B 151
 None
 0.71A 4ikiA-4a7lB:
undetectable		 4ikiA-4a7lB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 4a7l MYOSIN IE HEAVY
CHAIN
(Dictyostelium
discoideum) 		4 / 6 ASP C 341
GLU C 283
ILE C 279
PRO C 339
 None
 1.04A 4xi3C-4a7lC:
undetectable		 4xi3C-4a7lC:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4a7l MYOSIN IE HEAVY
CHAIN
(Dictyostelium
discoideum) 		4 / 7 THR C 576
LEU C 577
LEU C 573
THR C 180
 None
 0.91A 4z90A-4a7lC:
undetectable
4z90B-4a7lC:
undetectable
4z90C-4a7lC:
undetectable
4z90D-4a7lC:
undetectable
4z90E-4a7lC:
undetectable		 4z90A-4a7lC:
19.39
4z90B-4a7lC:
19.39
4z90C-4a7lC:
19.39
4z90D-4a7lC:
19.39
4z90E-4a7lC:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 4a7l MYOSIN IE HEAVY
CHAIN
(Dictyostelium
discoideum) 		4 / 7 GLU C  72
TYR C  71
ASP C  83
ALA C  79
 None
 1.21A 4zz8A-4a7lC:
undetectable		 4zz8A-4a7lC:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4a7l MYOSIN IE HEAVY
CHAIN
(Dictyostelium
discoideum) 		5 / 12 GLY C 389
ASN C 407
HIS C 507
TYR C 508
GLN C 400
 None
 1.41A 5jhnB-4a7lC:
undetectable		 5jhnB-4a7lC:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4a7l MYOSIN IE HEAVY
CHAIN
(Dictyostelium
discoideum) 		5 / 12 GLY C 389
ASN C 407
HIS C 507
TYR C 508
GLN C 400
 None
 1.43A 5jj0B-4a7lC:
undetectable		 5jj0B-4a7lC:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4a7l MYOSIN IE HEAVY
CHAIN
(Dictyostelium
discoideum) 		4 / 8 THR C 501
CYH C 478
TYR C 490
LEU C 474
 None
 1.39A 5kxiA-4a7lC:
undetectable
5kxiB-4a7lC:
undetectable		 5kxiA-4a7lC:
20.28
5kxiB-4a7lC:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4a7l MYOSIN IE HEAVY
CHAIN
(Dictyostelium
discoideum) 		4 / 8 THR C 501
CYH C 478
TYR C 490
LEU C 474
 None
 1.39A 5kxiD-4a7lC:
2.2
5kxiE-4a7lC:
undetectable		 5kxiD-4a7lC:
20.28
5kxiE-4a7lC:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 4a7l MYOSIN IE HEAVY
CHAIN
(Dictyostelium
discoideum) 		4 / 8 TYR C 630
ILE C 670
THR C 656
ILE C 659
 None
 0.83A 5mzrE-4a7lC:
2.2		 5mzrE-4a7lC:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4a7l MYOSIN IE HEAVY
CHAIN
(Dictyostelium
discoideum) 		5 / 12 GLY C 389
ASN C 407
HIS C 507
TYR C 508
GLN C 400
 None
 1.36A 5t0kA-4a7lC:
undetectable		 5t0kA-4a7lC:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4a7l MYOSIN IE HEAVY
CHAIN
(Dictyostelium
discoideum) 		5 / 11 ILE C 279
LEU C 320
LEU C 309
ILE C 276
TYR C 228
 None
 0.96A 5z6mA-4a7lC:
undetectable		 5z6mA-4a7lC:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4a7l MYOSIN IE HEAVY
CHAIN
(Dictyostelium
discoideum) 		4 / 8 TYR C 182
CYH C  96
TYR C 163
LEU C 413
 None
 1.45A 6cnjD-4a7lC:
2.5
6cnjE-4a7lC:
2.2		 6cnjD-4a7lC:
8.41
6cnjE-4a7lC:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 4a7l MYOSIN IE HEAVY
CHAIN
(Dictyostelium
discoideum) 		4 / 7 GLN C 411
GLY C 389
SER C 100
GLY C 101
 None
 0.89A 6ekzA-4a7lC:
undetectable		 6ekzA-4a7lC:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4a7l MYOSIN IE HEAVY
CHAIN
(Dictyostelium
discoideum) 		5 / 12 PHE C 390
GLY C 389
ILE C 387
HIS C 507
TYR C 514
 None
 1.41A 6md4A-4a7lC:
undetectable		 6md4A-4a7lC:
9.27