SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a7p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4a7p UDP-GLUCOSE
DEHYDROGENASE
(Sphingomonas
elodea) 		5 / 11 LEU A 413
GLU A 230
VAL A 432
LEU A 384
LEU A 410
 None
 1.36A 1mrqA-4a7pA:
undetectable		 1mrqA-4a7pA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4a7p UDP-GLUCOSE
DEHYDROGENASE
(Sphingomonas
elodea) 		5 / 7 ARG A 298
ILE A 339
ASP A 354
LEU A 322
GLY A 321
 None
 1.36A 1rtsB-4a7pA:
undetectable		 1rtsB-4a7pA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 4a7p UDP-GLUCOSE
DEHYDROGENASE
(Sphingomonas
elodea) 		4 / 4 SER A 338
ILE A 340
VAL A 387
THR A 430
 None
 1.18A 1u70A-4a7pA:
undetectable		 1u70A-4a7pA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 4a7p UDP-GLUCOSE
DEHYDROGENASE
(Sphingomonas
elodea) 		5 / 12 GLY A 347
ALA A 346
ILE A 340
VAL A 304
ILE A 305
 None
 0.81A 2o4sB-4a7pA:
undetectable		 2o4sB-4a7pA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4a7p UDP-GLUCOSE
DEHYDROGENASE
(Sphingomonas
elodea) 		3 / 3 ARG A 178
GLU A 175
SER A 189
 None
 0.88A 2xctD-4a7pA:
2.1		 2xctD-4a7pA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 4a7p UDP-GLUCOSE
DEHYDROGENASE
(Sphingomonas
elodea) 		3 / 3 PHE A 162
CYH A  18
PHE A  22
 None
 1.04A 3cr5X-4a7pA:
undetectable		 3cr5X-4a7pA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA303_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4a7p UDP-GLUCOSE
DEHYDROGENASE
(Sphingomonas
elodea) 		4 / 4 ARG A 201
VAL A 147
LYS A 145
GLU A 132
 None
 1.26A 3deuA-4a7pA:
0.0		 3deuA-4a7pA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4a7p UDP-GLUCOSE
DEHYDROGENASE
(Sphingomonas
elodea) 		4 / 6 ALA A 361
ALA A 334
PRO A 335
LEU A 322
 None
 1.12A 4dtzB-4a7pA:
undetectable		 4dtzB-4a7pA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 4a7p UDP-GLUCOSE
DEHYDROGENASE
(Sphingomonas
elodea) 		5 / 12 LEU A 365
GLY A 321
ALA A 361
PRO A 326
GLU A 389
 None
 1.28A 5x6yA-4a7pA:
2.0		 5x6yA-4a7pA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4a7p UDP-GLUCOSE
DEHYDROGENASE
(Sphingomonas
elodea) 		4 / 7 VAL A 387
ARG A 414
VAL A 432
GLY A 259
 None
 0.94A 5x80C-4a7pA:
undetectable
5x80D-4a7pA:
undetectable		 5x80C-4a7pA:
20.40
5x80D-4a7pA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 4a7p UDP-GLUCOSE
DEHYDROGENASE
(Sphingomonas
elodea) 		5 / 12 SER A  88
ASN A 212
GLY A 262
PHE A 324
ASP A 330
 None
 1.31A 6dwnA-4a7pA:
undetectable		 6dwnA-4a7pA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 4a7p UDP-GLUCOSE
DEHYDROGENASE
(Sphingomonas
elodea) 		5 / 10 ARG A 154
PHE A 324
GLY A 156
GLY A   9
VAL A  11
 None
None
None
NAD  A 501 (-3.2A)
NAD  A 501 (-4.2A)
 1.22A 6eu9B-4a7pA:
undetectable		 6eu9B-4a7pA:
10.32