SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a7w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4a7w URIDYLATE KINASE
(Helicobacter
pylori) 		5 / 12 ILE A  39
ALA A  36
LEU A  94
ALA A  93
VAL A  10
 None
 0.90A 1fbyA-4a7wA:
undetectable		 1fbyA-4a7wA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4a7w URIDYLATE KINASE
(Helicobacter
pylori) 		5 / 12 ILE A  39
ALA A  36
LEU A  94
ALA A  93
VAL A  10
 None
 0.94A 1fm6A-4a7wA:
undetectable		 1fm6A-4a7wA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4a7w URIDYLATE KINASE
(Helicobacter
pylori) 		5 / 12 ILE A  39
ALA A  36
LEU A  94
ALA A  93
VAL A  10
 None
 0.88A 1k74A-4a7wA:
undetectable		 1k74A-4a7wA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 4a7w URIDYLATE KINASE
(Helicobacter
pylori) 		5 / 12 ILE A  39
ALA A  36
LEU A  94
ALA A  93
VAL A  10
 None
 0.85A 1xiuA-4a7wA:
undetectable		 1xiuA-4a7wA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4a7w URIDYLATE KINASE
(Helicobacter
pylori) 		5 / 12 ILE A  39
ALA A  36
LEU A  94
ALA A  93
VAL A  10
 None
 0.91A 1xlsA-4a7wA:
undetectable		 1xlsA-4a7wA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4a7w URIDYLATE KINASE
(Helicobacter
pylori) 		5 / 12 ILE A  39
ALA A  36
LEU A  94
ALA A  93
VAL A  10
 None
 0.91A 1xlsB-4a7wA:
undetectable		 1xlsB-4a7wA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4a7w URIDYLATE KINASE
(Helicobacter
pylori) 		5 / 12 ILE A  39
ALA A  36
LEU A  94
ALA A  93
VAL A  10
 None
 0.91A 1xlsC-4a7wA:
undetectable		 1xlsC-4a7wA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4a7w URIDYLATE KINASE
(Helicobacter
pylori) 		5 / 12 ILE A  39
ALA A  36
LEU A  94
ALA A  93
VAL A  10
 None
 0.91A 1xlsD-4a7wA:
undetectable		 1xlsD-4a7wA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4a7w URIDYLATE KINASE
(Helicobacter
pylori) 		5 / 12 PHE A 133
GLY A 134
ASN A  86
LEU A  32
VAL A 130
 None
 1.26A 2nyrB-4a7wA:
4.5		 2nyrB-4a7wA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4a7w URIDYLATE KINASE
(Helicobacter
pylori) 		5 / 12 LEU A  94
ILE A  97
LEU A  99
VAL A  12
HIS A  34
 None
 1.21A 2qo6A-4a7wA:
undetectable		 2qo6A-4a7wA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YK1_H_NCTH300_1
(FAB FRAGMENT, HEAVY
CHAIN
FAB FRAGMENT, LIGHT
CHAIN)		 4a7w URIDYLATE KINASE
(Helicobacter
pylori) 		5 / 10 SER A 157
GLU A 154
TYR A 118
TYR A 116
ALA A 121
 None
 1.03A 2yk1H-4a7wA:
undetectable
2yk1L-4a7wA:
undetectable		 2yk1H-4a7wA:
21.09
2yk1L-4a7wA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4a7w URIDYLATE KINASE
(Helicobacter
pylori) 		6 / 12 ILE A  39
ALA A  36
LEU A  94
ALA A  93
VAL A  10
ILE A 161
 None
 1.33A 3oapA-4a7wA:
undetectable		 3oapA-4a7wA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 4a7w URIDYLATE KINASE
(Helicobacter
pylori) 		5 / 9 ILE A  53
ILE A 132
MET A  90
ILE A  39
ILE A  35
 None
 1.19A 3p4wB-4a7wA:
undetectable		 3p4wB-4a7wA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 4a7w URIDYLATE KINASE
(Helicobacter
pylori) 		5 / 10 ILE A  53
ILE A 132
MET A  90
ILE A  39
ILE A  35
 None
 1.19A 3p4wD-4a7wA:
undetectable		 3p4wD-4a7wA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 4a7w URIDYLATE KINASE
(Helicobacter
pylori) 		5 / 10 ILE A  53
ILE A 132
MET A  90
ILE A  39
ILE A  35
 None
 1.18A 3p4wE-4a7wA:
undetectable		 3p4wE-4a7wA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4a7w URIDYLATE KINASE
(Helicobacter
pylori) 		5 / 12 GLY A  21
HIS A  30
VAL A  31
HIS A  34
ILE A  35
 None
 0.83A 4rvdA-4a7wA:
2.9		 4rvdA-4a7wA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4a7w URIDYLATE KINASE
(Helicobacter
pylori) 		4 / 7 LEU A 183
ILE A 204
LYS A 240
VAL A 239
 None
 1.05A 5jh7C-4a7wA:
undetectable		 5jh7C-4a7wA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4a7w URIDYLATE KINASE
(Helicobacter
pylori) 		5 / 12 ILE A  39
ALA A  36
LEU A  94
ALA A  93
VAL A  10
 None
 0.92A 5uanA-4a7wA:
undetectable		 5uanA-4a7wA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4a7w URIDYLATE KINASE
(Helicobacter
pylori) 		5 / 12 ILE A  39
ALA A  36
LEU A  94
ALA A  93
VAL A  10
 None
 0.79A 5z12B-4a7wA:
undetectable		 5z12B-4a7wA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4a7w URIDYLATE KINASE
(Helicobacter
pylori) 		5 / 12 ILE A  39
ALA A  36
LEU A  94
ALA A  93
VAL A  10
 None
 0.86A 5z12C-4a7wA:
undetectable		 5z12C-4a7wA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 4a7w URIDYLATE KINASE
(Helicobacter
pylori) 		4 / 6 VAL A 228
LEU A 125
MET A  90
ARG A 151
 None
 1.21A 6brdB-4a7wA:
undetectable		 6brdB-4a7wA:
22.42