SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a8e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		4 / 7 ARG A 184
LEU A 181
LEU A 191
PHE A 192
 None
 0.95A 1v55P-4a8eA:
undetectable
1v55W-4a8eA:
undetectable		 1v55P-4a8eA:
19.68
1v55W-4a8eA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		4 / 7 ARG A 184
LEU A 181
LEU A 191
PHE A 192
 None
 0.88A 2dysC-4a8eA:
undetectable
2dysJ-4a8eA:
undetectable		 2dysC-4a8eA:
19.68
2dysJ-4a8eA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		4 / 7 ARG A 184
LEU A 181
LEU A 191
PHE A 192
 None
 1.02A 2eijP-4a8eA:
undetectable
2eijW-4a8eA:
undetectable		 2eijP-4a8eA:
19.68
2eijW-4a8eA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		4 / 8 ARG A 184
LEU A 181
LEU A 191
PHE A 192
 None
 0.86A 2eilC-4a8eA:
undetectable
2eilJ-4a8eA:
undetectable		 2eilC-4a8eA:
19.68
2eilJ-4a8eA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		4 / 7 ARG A 184
LEU A 181
LEU A 191
PHE A 192
 None
 0.91A 2einC-4a8eA:
undetectable
2einJ-4a8eA:
undetectable		 2einC-4a8eA:
19.68
2einJ-4a8eA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		4 / 6 ARG A 184
LEU A 181
LEU A 191
PHE A 192
 None
 0.93A 2einP-4a8eA:
undetectable
2einW-4a8eA:
undetectable		 2einP-4a8eA:
19.68
2einW-4a8eA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		6 / 12 GLY A 131
VAL A 147
ILE A 177
ILE A 125
VAL A 156
ILE A 154
 None
 1.43A 2q64B-4a8eA:
undetectable		 2q64B-4a8eA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		4 / 7 ARG A 184
LEU A 181
LEU A 191
PHE A 192
 None
 0.83A 2zxwC-4a8eA:
undetectable
2zxwJ-4a8eA:
undetectable		 2zxwC-4a8eA:
19.68
2zxwJ-4a8eA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		4 / 6 ARG A 184
LEU A 181
LEU A 191
PHE A 192
 None
 0.88A 2zxwP-4a8eA:
undetectable
2zxwW-4a8eA:
undetectable		 2zxwP-4a8eA:
19.68
2zxwW-4a8eA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		5 / 11 ILE A 169
LEU A 124
LEU A 174
ILE A 177
LEU A 142
 None
 1.28A 3a50C-4a8eA:
2.7		 3a50C-4a8eA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		4 / 6 ARG A 184
LEU A 181
LEU A 191
PHE A 192
 None
 0.88A 3ag1C-4a8eA:
undetectable
3ag1J-4a8eA:
undetectable		 3ag1C-4a8eA:
19.68
3ag1J-4a8eA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		4 / 5 SER A 172
LEU A 128
GLY A 131
GLU A 176
 None
 1.15A 3aiaA-4a8eA:
undetectable
3aiaB-4a8eA:
undetectable		 3aiaA-4a8eA:
24.09
3aiaB-4a8eA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		6 / 12 GLY A 131
VAL A 147
ILE A 177
ILE A 125
VAL A 156
ILE A 154
 None
 1.33A 3el1B-4a8eA:
undetectable		 3el1B-4a8eA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		5 / 10 ILE A 177
VAL A 147
ILE A 154
ILE A 169
SER A 170
 None
 1.32A 3kpbD-4a8eA:
undetectable		 3kpbD-4a8eA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		4 / 8 PHE A 232
VAL A 167
ILE A 154
ILE A 177
 None
 0.88A 3uqbA-4a8eA:
undetectable		 3uqbA-4a8eA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		4 / 8 TYR A 180
VAL A 147
ILE A 154
LEU A 139
 None
 0.61A 4jq1B-4a8eA:
undetectable		 4jq1B-4a8eA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		4 / 7 ARG A 184
LEU A 181
LEU A 191
PHE A 192
 None
 0.95A 5b1aC-4a8eA:
undetectable
5b1aJ-4a8eA:
undetectable		 5b1aC-4a8eA:
19.68
5b1aJ-4a8eA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		4 / 7 ARG A 184
LEU A 181
LEU A 191
PHE A 192
 None
 0.95A 5b1aP-4a8eA:
undetectable
5b1aW-4a8eA:
undetectable		 5b1aP-4a8eA:
19.68
5b1aW-4a8eA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		4 / 7 ARG A 184
LEU A 181
LEU A 191
PHE A 192
 None
 0.88A 5b1bP-4a8eA:
undetectable
5b1bW-4a8eA:
undetectable		 5b1bP-4a8eA:
19.68
5b1bW-4a8eA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		4 / 5 ARG A 184
LEU A 181
LEU A 191
PHE A 192
 None
 0.93A 5iy5P-4a8eA:
undetectable
5iy5W-4a8eA:
undetectable		 5iy5P-4a8eA:
17.61
5iy5W-4a8eA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		4 / 6 ARG A 184
LEU A 181
LEU A 191
PHE A 192
 None
 0.89A 5w97C-4a8eA:
undetectable
5w97J-4a8eA:
undetectable		 5w97C-4a8eA:
19.68
5w97J-4a8eA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		4 / 5 ARG A 184
LEU A 181
LEU A 191
PHE A 192
 None
 0.92A 5x19C-4a8eA:
undetectable
5x19J-4a8eA:
undetectable		 5x19C-4a8eA:
19.68
5x19J-4a8eA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		4 / 5 ARG A 184
LEU A 181
LEU A 191
PHE A 192
 None
 0.92A 5x1fC-4a8eA:
undetectable
5x1fJ-4a8eA:
undetectable		 5x1fC-4a8eA:
19.68
5x1fJ-4a8eA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		4 / 5 ARG A 184
LEU A 181
LEU A 191
PHE A 192
 None
 0.94A 5xdxC-4a8eA:
undetectable
5xdxJ-4a8eA:
undetectable		 5xdxC-4a8eA:
17.88
5xdxJ-4a8eA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		4 / 5 ARG A 184
LEU A 181
LEU A 191
PHE A 192
 None
 0.98A 5xdxP-4a8eA:
undetectable
5xdxW-4a8eA:
undetectable		 5xdxP-4a8eA:
17.88
5xdxW-4a8eA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE
(Pyrococcus
abyssi) 		4 / 5 LEU A 223
VAL A 221
GLU A 109
LEU A 105
 None
 0.91A 5xooB-4a8eA:
undetectable		 5xooB-4a8eA:
14.13