SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a8j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4a8j ELONGATOR COMPLEX
PROTEIN 5
(Saccharomyces
cerevisiae) 		4 / 4 SER B 185
ASP B 172
ARG B 205
ASP B 219
 None
 1.23A 2bm9C-4a8jB:
2.9		 2bm9C-4a8jB:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4a8j ELONGATOR COMPLEX
PROTEIN 5
(Saccharomyces
cerevisiae) 		3 / 3 ASN B 110
ILE B  58
MET B 131
 None
 0.75A 2h42C-4a8jB:
undetectable		 2h42C-4a8jB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 4a8j ELONGATOR COMPLEX
PROTEIN 4
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 160
SER A 330
LEU A 122
 None
 0.57A 2w1bA-4a8jA:
undetectable		 2w1bA-4a8jA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 4a8j ELONGATOR COMPLEX
PROTEIN 5
(Saccharomyces
cerevisiae) 		4 / 5 VAL B 184
VAL B 173
ASP B 172
SER B  30
 None
 1.01A 2x45A-4a8jB:
undetectable		 2x45A-4a8jB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 4a8j ELONGATOR COMPLEX
PROTEIN 5
(Saccharomyces
cerevisiae) 		4 / 5 VAL B 184
VAL B 173
ASP B 172
SER B  30
 None
 0.96A 2x45C-4a8jB:
undetectable		 2x45C-4a8jB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4a8j ELONGATOR COMPLEX
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 9 MET A 347
LEU A 310
ILE A 288
LEU A 291
PHE A 348
 None
 1.31A 3fl9H-4a8jA:
undetectable		 3fl9H-4a8jA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4a8j ELONGATOR COMPLEX
PROTEIN 4
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 164
PRO A 165
LEU A 247
 None
 0.54A 3hcrA-4a8jA:
2.5		 3hcrA-4a8jA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 4a8j ELONGATOR COMPLEX
PROTEIN 4
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 251
PHE A 160
ALA A 127
 None
 0.70A 3itaD-4a8jA:
undetectable		 3itaD-4a8jA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 4a8j ELONGATOR COMPLEX
PROTEIN 5
(Saccharomyces
cerevisiae) 		3 / 3 ASP B 172
GLU B 217
SER B 185
 None
 0.81A 3p2kA-4a8jB:
undetectable		 3p2kA-4a8jB:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 4a8j ELONGATOR COMPLEX
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 276
ILE A 272
VAL A 314
LEU A 317
 None
 0.68A 3r9vA-4a8jA:
undetectable
3r9vB-4a8jA:
undetectable		 3r9vA-4a8jA:
22.86
3r9vB-4a8jA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4a8j ELONGATOR COMPLEX
PROTEIN 4
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 242
ARG A 408
LYS A 409
 None
 1.25A 3wipG-4a8jA:
undetectable		 3wipG-4a8jA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 4a8j ELONGATOR COMPLEX
PROTEIN 5
(Saccharomyces
cerevisiae) 		4 / 6 ILE B  25
ILE B  39
SER B  35
LEU B 204
 None
 0.99A 4m51A-4a8jB:
undetectable		 4m51A-4a8jB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 4a8j ELONGATOR COMPLEX
PROTEIN 5
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 204
LEU B  12
ILE B  15
LEU B  16
PHE B  42
 None
 0.97A 4odrA-4a8jB:
undetectable
4odrB-4a8jB:
undetectable		 4odrA-4a8jB:
16.42
4odrB-4a8jB:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4a8j ELONGATOR COMPLEX
PROTEIN 5
(Saccharomyces
cerevisiae) 		4 / 7 GLU B  61
PHE B  60
TYR B 135
HIS B 136
 None
 1.01A 4uciB-4a8jB:
undetectable		 4uciB-4a8jB:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4a8j ELONGATOR COMPLEX
PROTEIN 5
(Saccharomyces
cerevisiae) 		3 / 3 SER B 108
ALA B 133
VAL B 132
 None
 0.51A 4x1iA-4a8jB:
undetectable		 4x1iA-4a8jB:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4a8j ELONGATOR COMPLEX
PROTEIN 5
(Saccharomyces
cerevisiae) 		3 / 3 SER B 108
ALA B 133
VAL B 132
 None
 0.48A 5eypA-4a8jB:
undetectable		 5eypA-4a8jB:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 4a8j ELONGATOR COMPLEX
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 5 VAL A  75
ASN A 146
ASP A  69
LEU A  68
 None
 1.28A 5m0iB-4a8jA:
undetectable		 5m0iB-4a8jA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4a8j ELONGATOR COMPLEX
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 289
GLY A 123
LEU A 164
VAL A 153
 None
 0.96A 5x80A-4a8jA:
undetectable
5x80B-4a8jA:
undetectable		 5x80A-4a8jA:
20.49
5x80B-4a8jA:
20.49