SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4a9a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 10 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.92A 1d4yA-4a9aA:
undetectable
1d4yA-4a9aA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
4 / 7 ALA A 221
SER A 217
SER A 191
THR A 193
None
1.01A 1dvxA-4a9aA:
undetectable
1dvxA-4a9aA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 ALA A 112
TRP A 288
LEU A 293
LEU A 313
LEU A 284
None
1.02A 1errB-4a9aA:
undetectable
1errB-4a9aA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 ILE A 122
GLY A  69
VAL A  71
ALA A  66
SER A  67
None
1.05A 1kiaA-4a9aA:
undetectable
1kiaA-4a9aA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
4 / 7 GLU A  12
ARG A 172
LEU A  35
GLY A 170
None
0.86A 1mt1H-4a9aA:
undetectable
1mt1K-4a9aA:
undetectable
1mt1H-4a9aA:
14.81
1mt1K-4a9aA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
4 / 7 GLU A  12
ARG A 172
LEU A  35
GLY A 170
None
0.82A 1n13D-4a9aA:
undetectable
1n13E-4a9aA:
undetectable
1n13D-4a9aA:
14.81
1n13E-4a9aA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
4 / 8 LEU A  35
GLY A 170
GLU A  12
ARG A 172
None
0.80A 1n13A-4a9aA:
undetectable
1n13F-4a9aA:
undetectable
1n13A-4a9aA:
11.49
1n13F-4a9aA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
4 / 6 GLU A  12
ARG A 172
LEU A  35
GLY A 170
None
0.74A 1n13H-4a9aA:
undetectable
1n13K-4a9aA:
undetectable
1n13H-4a9aA:
14.81
1n13K-4a9aA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
4 / 7 LEU A  35
GLY A 170
GLU A  12
ARG A 172
None
0.76A 1n13G-4a9aA:
undetectable
1n13J-4a9aA:
undetectable
1n13G-4a9aA:
11.49
1n13J-4a9aA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 ILE A 122
GLY A  69
VAL A  71
ALA A  66
SER A  67
None
1.05A 1nbhA-4a9aA:
undetectable
1nbhA-4a9aA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 ILE A 122
GLY A  69
VAL A  71
ALA A  66
SER A  67
None
1.04A 1nbhB-4a9aA:
undetectable
1nbhB-4a9aA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 ILE A 122
GLY A  69
VAL A  71
ALA A  66
SER A  67
None
1.05A 1nbhC-4a9aA:
undetectable
1nbhC-4a9aA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 ILE A 122
GLY A  69
VAL A  71
ALA A  66
SER A  67
None
1.05A 1nbhD-4a9aA:
undetectable
1nbhD-4a9aA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 ILE A 122
GLY A  69
VAL A  71
ALA A  66
SER A  67
None
1.12A 1nbiA-4a9aA:
undetectable
1nbiA-4a9aA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 ILE A 122
GLY A  69
VAL A  71
ALA A  66
SER A  67
None
1.11A 1nbiB-4a9aA:
undetectable
1nbiB-4a9aA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 VAL A 209
ILE A 206
ILE A 220
PHE A 222
ILE A 182
None
0.82A 1qhsA-4a9aA:
3.0
1qhsA-4a9aA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 VAL A 209
ILE A 206
ILE A 220
PHE A 222
ILE A 182
None
0.80A 1qhyA-4a9aA:
undetectable
1qhyA-4a9aA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)
4a9a RIBOSOME-INTERACTING
GTPASE 1
TRANSLATION
MACHINERY-ASSOCIATED
PROTEIN 46

(Saccharomyces
cerevisiae)
4 / 7 THR C 221
ASN A 268
TYR A 247
LEU A 249
None
0.99A 1qzrA-4a9aC:
undetectable
1qzrA-4a9aC:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)
4a9a RIBOSOME-INTERACTING
GTPASE 1
TRANSLATION
MACHINERY-ASSOCIATED
PROTEIN 46

(Saccharomyces
cerevisiae)
4 / 7 THR C 221
ASN A 268
TYR A 247
LEU A 249
None
0.98A 1qzrB-4a9aC:
undetectable
1qzrB-4a9aC:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 10 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.79A 1sdtA-4a9aA:
undetectable
1sdtA-4a9aA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 11 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.78A 1sduA-4a9aA:
undetectable
1sduA-4a9aA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 10 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.90A 1t3rA-4a9aA:
undetectable
1t3rA-4a9aA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 TYR A 213
ALA A  36
VAL A 209
ALA A 208
LEU A 201
None
1.06A 1udtA-4a9aA:
undetectable
1udtA-4a9aA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 TYR A 213
ALA A  36
VAL A 209
ALA A 208
LEU A 201
None
1.01A 1uduB-4a9aA:
undetectable
1uduB-4a9aA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
3 / 3 TRP A 278
LEU A 280
LYS A  84
None
1.35A 1yajK-4a9aA:
undetectable
1yajK-4a9aA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 9 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.95A 2avoA-4a9aA:
undetectable
2avoA-4a9aA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 TYR A 213
ALA A  36
VAL A 209
ALA A 208
LEU A 201
None
1.10A 2h42B-4a9aA:
undetectable
2h42B-4a9aA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 LEU A 280
LEU A  85
ILE A 252
LEU A 145
VAL A  68
None
1.22A 2hrcA-4a9aA:
3.5
2hrcA-4a9aA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 9 LEU A 201
ILE A 192
ILE A 220
ALA A 226
LEU A 198
None
1.05A 2m9qA-4a9aA:
undetectable
2m9qA-4a9aA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.81A 2nnkB-4a9aA:
undetectable
2nnkB-4a9aA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 11 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.92A 2o4pA-4a9aA:
undetectable
2o4pA-4a9aA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
4 / 7 LEU A  31
LEU A  38
MET A  15
GLU A  14
None
0.93A 2qqdA-4a9aA:
undetectable
2qqdE-4a9aA:
undetectable
2qqdA-4a9aA:
11.71
2qqdE-4a9aA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
4 / 8 GLU A  12
ARG A 172
LEU A  35
GLY A 170
None
0.83A 2qqdB-4a9aA:
undetectable
2qqdC-4a9aA:
undetectable
2qqdB-4a9aA:
15.38
2qqdC-4a9aA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.76A 2r5pA-4a9aA:
undetectable
2r5pA-4a9aA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.76A 2r5pC-4a9aA:
undetectable
2r5pC-4a9aA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
4a9a RIBOSOME-INTERACTING
GTPASE 1
TRANSLATION
MACHINERY-ASSOCIATED
PROTEIN 46

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
4 / 8 TYR A 297
SER A 344
GLN A 348
ILE C 275
None
1.00A 2xz5B-4a9aA:
undetectable
2xz5E-4a9aA:
undetectable
2xz5B-4a9aA:
19.48
2xz5E-4a9aA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 ILE A  56
ASN A 174
ALA A 138
VAL A 101
LEU A 119
None
1.05A 3a51E-4a9aA:
2.7
3a51E-4a9aA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.81A 3bvbA-4a9aA:
undetectable
3bvbA-4a9aA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 9 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.81A 3d1yB-4a9aA:
undetectable
3d1yB-4a9aA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 10 ILE A 171
GLY A 170
LEU A  42
VAL A 136
ILE A 122
None
1.04A 3em4V-4a9aA:
undetectable
3em4V-4a9aA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 VAL A 352
LEU A 358
SER A 344
VAL A 320
ILE A 296
None
1.26A 3frqA-4a9aA:
undetectable
3frqA-4a9aA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)
4a9a RIBOSOME-INTERACTING
GTPASE 1
TRANSLATION
MACHINERY-ASSOCIATED
PROTEIN 46

(Saccharomyces
cerevisiae)
4 / 4 PRO A 300
THR A 365
GLY C 272
THR C 271
None
1.14A 3ib1A-4a9aA:
undetectable
3ib1A-4a9aA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.77A 3k4vC-4a9aA:
undetectable
3k4vC-4a9aA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
4 / 8 ASP A 277
LEU A  81
LEU A 280
ASN A 250
None
1.02A 3lm8A-4a9aA:
undetectable
3lm8C-4a9aA:
undetectable
3lm8A-4a9aA:
20.58
3lm8C-4a9aA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 10 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.93A 3lzvA-4a9aA:
undetectable
3lzvA-4a9aA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_1
(PROTEASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.79A 3ndtC-4a9aA:
undetectable
3ndtC-4a9aA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.89A 3nduA-4a9aA:
undetectable
3nduA-4a9aA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.76A 3nduC-4a9aA:
undetectable
3nduC-4a9aA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.80A 3tkgA-4a9aA:
undetectable
3tkgA-4a9aA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.85A 4dqfA-4a9aA:
undetectable
4dqfA-4a9aA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 LEU A 145
LEU A 146
GLY A  69
VAL A 248
ILE A 107
None
1.34A 4oktA-4a9aA:
undetectable
4oktA-4a9aA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 11 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.92A 4q1xA-4a9aA:
undetectable
4q1xA-4a9aA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.92A 4q1xB-4a9aA:
undetectable
4q1xB-4a9aA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.81A 4q1yB-4a9aA:
undetectable
4q1yB-4a9aA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 VAL A  65
LEU A 284
LEU A 145
ASN A 144
PHE A 147
None
1.49A 4qdcA-4a9aA:
undetectable
4qdcA-4a9aA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 SER A  75
VAL A 248
ILE A 272
ILE A 149
GLY A  72
None
0.98A 4y8wC-4a9aA:
undetectable
4y8wC-4a9aA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 ALA A 140
GLY A 105
SER A  67
GLY A  69
LEU A 146
None
1.06A 5i75A-4a9aA:
3.7
5i75A-4a9aA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 10 ILE A 272
LEU A  81
VAL A  68
LEU A 145
LEU A 249
None
1.07A 5ienB-4a9aA:
undetectable
5ienB-4a9aA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.80A 5kqyA-4a9aA:
undetectable
5kqyA-4a9aA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 10 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.80A 5kr1A-4a9aA:
undetectable
5kr1A-4a9aA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 9 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.79A 5kr2D-4a9aA:
undetectable
5kr2D-4a9aA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 10 VAL A 286
GLU A 282
LEU A 166
PRO A 271
LEU A 249
None
1.34A 5mm4B-4a9aA:
undetectable
5mm4B-4a9aA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
4 / 7 VAL A 364
ILE A 366
VAL A 352
ALA A 338
None
0.52A 5osrA-4a9aA:
undetectable
5osrA-4a9aA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 LEU A 166
GLY A  69
LEU A 283
VAL A 248
LEU A 293
None
1.03A 5ycnA-4a9aA:
undetectable
5ycnA-4a9aA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.75A 6difB-4a9aA:
undetectable
6difB-4a9aA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae)
5 / 12 LEU A 145
ILE A 122
GLY A  72
ILE A 149
VAL A  68
None
0.98A 6dilA-4a9aA:
undetectable
6dilA-4a9aA:
13.44