SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4aaj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4aaj N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Pyrococcus
furiosus) 		4 / 8 ARG A 152
SER A 147
ARG A 145
VAL A 150
 None
 1.20A 1u1jA-4aajA:
10.1		 1u1jA-4aajA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 4aaj N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Pyrococcus
furiosus) 		5 / 10 THR A  71
VAL A  28
VAL A  27
VAL A  52
ILE A  45
 None
 1.45A 2qboA-4aajA:
undetectable		 2qboA-4aajA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 4aaj N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Pyrococcus
furiosus) 		3 / 3 ARG A 124
GLN A  85
PRO A  84
 None
 0.95A 2qhfA-4aajA:
undetectable		 2qhfA-4aajA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4aaj N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Pyrococcus
furiosus) 		4 / 5 LEU A 118
LEU A 119
LEU A 149
SER A 148
 None
 1.03A 3vhuA-4aajA:
undetectable		 3vhuA-4aajA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4aaj N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Pyrococcus
furiosus) 		5 / 11 VAL A 156
PHE A 199
GLY A 160
GLY A 161
ASN A 163
 None
None
SO4  A1207 ( 3.8A)
SO4  A1207 (-3.5A)
None
 1.41A 4zvmA-4aajA:
undetectable
4zvmB-4aajA:
undetectable		 4zvmA-4aajA:
20.85
4zvmB-4aajA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 4aaj N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Pyrococcus
furiosus) 		4 / 7 ILE A  36
ARG A  34
VAL A  26
GLU A  13
 None
 0.91A 4zzbC-4aajA:
undetectable
4zzbD-4aajA:
undetectable		 4zzbC-4aajA:
21.28
4zzbD-4aajA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 4aaj N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Pyrococcus
furiosus) 		4 / 6 ILE A  36
ARG A  34
ILE A   8
GLU A  13
 None
 1.22A 4zzcA-4aajA:
undetectable
4zzcB-4aajA:
undetectable		 4zzcA-4aajA:
20.82
4zzcB-4aajA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 4aaj N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Pyrococcus
furiosus) 		4 / 6 ILE A  36
ARG A  34
ILE A   8
GLU A  13
 None
 1.15A 4zzcB-4aajA:
undetectable
4zzcC-4aajA:
undetectable		 4zzcB-4aajA:
20.82
4zzcC-4aajA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4aaj N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 149
ALA A 115
PRO A 105
SER A 108
ARG A 145
 None
 1.31A 5ljbA-4aajA:
undetectable		 5ljbA-4aajA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B50_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 4aaj N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 144
VAL A 179
VAL A 158
SER A 147
MET A   1
 None
 1.41A 6b50A-4aajA:
undetectable		 6b50A-4aajA:
23.57