SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4aay'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JLF_A_NVPA999_1 (HIV-1 RT A-CHAIN HIV-1 RT B-CHAIN)	4aay	AROB (Rhizobium sp. NT-26)	4 / 8	LEU B 79 VAL B 90 TYR B 148 GLY B 89	None	1.03A	1jlfA-4aayB: undetectable 1jlfB-4aayB: undetectable	1jlfA-4aayB: 15.54 1jlfB-4aayB: 18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YVM_A_TMGA501_1 (METHIONINE AMINOPEPTIDASE)	4aay	AROB (Rhizobium sp. NT-26)	4 / 7	CYH B 103 TYR B 168 CYH B 121 HIS B 124	FES B2006 (-2.3A) None FES B2006 (-2.2A) FES B2006 (-3.0A)	1.38A	1yvmA-4aayB: undetectable	1yvmA-4aayB: 23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XZ5_D_ACHD1211_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4aay	AROB (Rhizobium sp. NT-26)	4 / 8	GLN B 143 TYR B 168 SER B 126 CYH B 121	None None FES B2006 (-2.9A) FES B2006 (-2.2A)	1.20A	2xz5C-4aayB: undetectable 2xz5D-4aayB: undetectable	2xz5C-4aayB: 19.63 2xz5D-4aayB: 19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AGA_A_ACTA1131_0 (LYSOZYME C)	4aay	AROB (Rhizobium sp. NT-26)	3 / 3	ASN B 155 ASP B 157 ASN B 56	None	0.75A	4agaA-4aayB: undetectable	4agaA-4aayB: 21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CP3_B_RBTB1129_1 (B-CELL LYMPHOMA 6 PROTEIN)	4aay	AROB (Rhizobium sp. NT-26)	4 / 7	ASN B 52 LEU B 54 GLY B 162 TYR B 148	None	0.98A	4cp3A-4aayB: undetectable 4cp3B-4aayB: undetectable	4cp3A-4aayB: 20.55 4cp3B-4aayB: 20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UYM_A_VORA590_1 (14-ALPHA STEROL DEMETHYLASE)	4aay	AROB (Rhizobium sp. NT-26)	4 / 7	ALA B 141 SER B 126 LEU B 145 PHE B 128	None FES B2006 (-2.9A) None None	1.07A	4uymA-4aayB: undetectable	4uymA-4aayB: 16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_O_BEZO801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	4aay	AROB (Rhizobium sp. NT-26)	4 / 6	PHE B 108 SER B 126 PRO B 122 LEU B 110	None FES B2006 (-2.9A) None None	1.45A	5dzka-4aayB: undetectable 5dzko-4aayB: undetectable	5dzka-4aayB: 19.82 5dzko-4aayB: 2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NNA_D_BZMD301_0 (ISATIN HYDROLASE A)	4aay	AROB (Rhizobium sp. NT-26)	5 / 12	ILE B 158 LEU B 79 GLY B 91 ASP B 95 GLY B 89	None	1.18A	5nnaD-4aayB: undetectable	5nnaD-4aayB: 22.90

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1JLF_A_NVPA999_1","HIV-1 RT A-CHAIN;HIV-1 RT B-CHAIN","4aay","AROB","Rhizobium sp. NT-26",4,"LEU B  79;VAL B  90;TYR B 148;GLY B  89","None","1.03A","1jlfA-4aayB:undetectable;1jlfB-4aayB:undetectable","1jlfA-4aayB:15.54;1jlfB-4aayB:18.18"],["1YVM_A_TMGA501_1","METHIONINE AMINOPEPTIDASE","4aay","AROB","Rhizobium sp. NT-26",4,"CYH B 103;TYR B 168;CYH B 121;HIS B 124","FES B2006 (-2.3A);None;FES B2006 (-2.2A);FES B2006 (-3.0A)","1.38A","1yvmA-4aayB:undetectable","1yvmA-4aayB:23.53"],["2XZ5_D_ACHD1211_0","SOLUBLE ACETYLCHOLINE RECEPTOR","4aay","AROB","Rhizobium sp. NT-26",4,"GLN B 143;TYR B 168;SER B 126;CYH B 121","None;None;FES B2006 (-2.9A);FES B2006 (-2.2A)","1.20A","2xz5C-4aayB:undetectable;2xz5D-4aayB:undetectable","2xz5C-4aayB:19.63;2xz5D-4aayB:19.63"],["4AGA_A_ACTA1131_0","LYSOZYME C","4aay","AROB","Rhizobium sp. NT-26",3,"ASN B 155;ASP B 157;ASN B  56","None","0.75A","4agaA-4aayB:undetectable","4agaA-4aayB:21.14"],["4CP3_B_RBTB1129_1","B-CELL LYMPHOMA 6 PROTEIN;B-CELL LYMPHOMA 6 PROTEIN","4aay","AROB","Rhizobium sp. NT-26",4,"ASN B  52;LEU B  54;GLY B 162;TYR B 148","None","0.98A","4cp3A-4aayB:undetectable;4cp3B-4aayB:undetectable","4cp3A-4aayB:20.55;4cp3B-4aayB:20.55"],["4UYM_A_VORA590_1","14-ALPHA STEROL DEMETHYLASE","4aay","AROB","Rhizobium sp. NT-26",4,"ALA B 141;SER B 126;LEU B 145;PHE B 128","None;FES B2006 (-2.9A);None;None","1.07A","4uymA-4aayB:undetectable","4uymA-4aayB:16.99"],["5DZK_O_BEZO801_0","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2;BEZ-LEU-LEU","4aay","AROB","Rhizobium sp. NT-26",4,"PHE B 108;SER B 126;PRO B 122;LEU B 110","None;FES B2006 (-2.9A);None;None","1.45A","5dzka-4aayB:undetectable;5dzko-4aayB:undetectable","5dzka-4aayB:19.82;5dzko-4aayB:2.50"],["5NNA_D_BZMD301_0","ISATIN HYDROLASE A","4aay","AROB","Rhizobium sp. NT-26",5,"ILE B 158;LEU B  79;GLY B  91;ASP B  95;GLY B  89","None","1.18A","5nnaD-4aayB:undetectable","5nnaD-4aayB:22.90"]]