SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4abk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4abk POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 12 TYR A1209
PHE A1229
LEU A1315
VAL A1311
VAL A1366
 None
 1.33A 1q23B-4abkA:
undetectable		 1q23B-4abkA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4abk POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 10 TYR A1209
PHE A1229
LEU A1315
VAL A1311
VAL A1366
 None
 1.37A 1q23E-4abkA:
undetectable		 1q23E-4abkA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4abk POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 11 TYR A1209
PHE A1229
LEU A1315
VAL A1311
VAL A1366
 None
 1.35A 1q23F-4abkA:
undetectable		 1q23F-4abkA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4abk POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 12 GLY A1257
ALA A1261
THR A1237
ILE A1244
ILE A1326
 AR6  A2389 (-3.4A)
AR6  A2389 (-3.5A)
None
None
None
 1.33A 3ld6A-4abkA:
undetectable		 3ld6A-4abkA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRI_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 4abk POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 10 TYR A1220
VAL A1212
TYR A1209
ILE A1224
ILE A1348
 None
 1.35A 3vriA-4abkA:
undetectable
3vriC-4abkA:
undetectable		 3vriA-4abkA:
22.86
3vriC-4abkA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 4abk POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 9 VAL A1258
ILE A1262
LEU A1263
ILE A1236
GLY A1290
 AR6  A2389 (-3.9A)
None
None
AR6  A2389 (-3.9A)
None
 1.11A 4kukA-4abkA:
undetectable		 4kukA-4abkA:
20.97