SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4aby'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 4aby DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		4 / 6 LEU A 155
ILE A 399
ARG A 400
VAL A 445
 None
 1.08A 1db1A-4abyA:
undetectable		 1db1A-4abyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 4aby DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		5 / 11 ALA A  65
ILE A  45
PHE A  59
LEU A  37
ILE A  70
 None
 1.19A 1dg5A-4abyA:
undetectable		 1dg5A-4abyA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 4aby DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		4 / 7 LEU A 125
GLU A 137
ALA A 139
ALA A 123
 None
 1.15A 1sn0B-4abyA:
undetectable
1sn0D-4abyA:
undetectable		 1sn0B-4abyA:
15.69
1sn0D-4abyA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 4aby DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		5 / 12 GLY A  53
GLY A  54
GLY A  55
LEU A 500
TRP A 100
 None
 1.16A 1xdsA-4abyA:
undetectable		 1xdsA-4abyA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4aby DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		5 / 12 LEU A 396
LEU A 163
ARG A 166
MET A 409
LEU A 442
 None
 1.38A 1ya3B-4abyA:
undetectable		 1ya3B-4abyA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4aby DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		5 / 12 LEU A 396
LEU A 163
ARG A 166
MET A 409
LEU A 442
 None
 1.44A 2oaxC-4abyA:
undetectable		 2oaxC-4abyA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4aby DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		5 / 12 GLY A  98
ALA A 111
ALA A 123
LEU A 135
LEU A  34
 None
 1.17A 3p5nA-4abyA:
undetectable		 3p5nA-4abyA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4aby DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		5 / 12 GLY A  98
ALA A 111
ALA A 123
LEU A 135
LEU A  34
 None
 1.16A 3p5nB-4abyA:
undetectable		 3p5nB-4abyA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4aby DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		5 / 12 LEU A 396
LEU A 163
ARG A 166
MET A 409
LEU A 442
 None
 1.42A 3vhuA-4abyA:
undetectable		 3vhuA-4abyA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 4aby DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		6 / 12 ALA A  65
ILE A  45
PHE A  59
LEU A  37
LEU A  52
ILE A  70
 None
 1.24A 4m2xA-4abyA:
undetectable		 4m2xA-4abyA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 4aby DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		4 / 4 ILE A  87
ASN A  41
ILE A  39
VAL A  96
 None
 1.11A 4uy87-4abyA:
undetectable		 4uy87-4abyA:
2.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 4aby DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		3 / 3 ARG A 384
ASP A 165
TYR A 422
 None
 0.85A 4yo9B-4abyA:
undetectable		 4yo9B-4abyA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 4aby DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		5 / 12 GLY A  79
LEU A 143
LEU A  37
ARG A  81
ASP A  72
 None
 1.09A 5w7pA-4abyA:
undetectable		 5w7pA-4abyA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4aby DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		4 / 6 GLY A  75
LEU A  86
ARG A 113
VAL A  96
 None
 0.83A 5x80A-4abyA:
1.5
5x80B-4abyA:
undetectable		 5x80A-4abyA:
19.32
5x80B-4abyA:
19.32