SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ac0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		5 / 12 ILE A  10
LEU A  16
ALA A  13
THR A  40
LEU A   4
 None
 1.12A 1og5B-4ac0A:
undetectable		 1og5B-4ac0A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		5 / 10 GLY A  35
VAL A  36
LEU A   4
SER A   2
ALA A  31
 None
 1.13A 1pbcA-4ac0A:
undetectable		 1pbcA-4ac0A:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		6 / 12 HIS A  64
PHE A  86
HIS A 100
ARG A 104
PRO A 105
THR A 112
 MIY  A1204 (-3.8A)
MIY  A1204 (-3.5A)
MG  A1205 ( 3.2A)
MIY  A1204 (-4.2A)
MIY  A1204 (-4.4A)
MIY  A1204 ( 4.7A)
 0.85A 2fj1A-4ac0A:
26.4		 2fj1A-4ac0A:
65.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		7 / 12 HIS A  64
PHE A  86
HIS A 100
PRO A 105
THR A 112
GLN A 116
LEU A 131
 MIY  A1204 (-3.8A)
MIY  A1204 (-3.5A)
MG  A1205 ( 3.2A)
MIY  A1204 (-4.4A)
MIY  A1204 ( 4.7A)
MIY  A1204 (-2.8A)
MIY  A1204 (-4.3A)
 0.61A 2fj1A-4ac0A:
26.4		 2fj1A-4ac0A:
65.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		7 / 12 HIS A  64
ASN A  82
PHE A  86
HIS A 100
PRO A 105
THR A 112
GLN A 116
 MIY  A1204 (-3.8A)
MIY  A1204 (-3.0A)
MIY  A1204 (-3.5A)
MG  A1205 ( 3.2A)
MIY  A1204 (-4.4A)
MIY  A1204 ( 4.7A)
MIY  A1204 (-2.8A)
 0.50A 2o7oA-4ac0A:
26.1		 2o7oA-4ac0A:
65.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		6 / 12 HIS A  64
PHE A  86
HIS A 100
ARG A 104
PRO A 105
THR A 112
 MIY  A1204 (-3.8A)
MIY  A1204 (-3.5A)
MG  A1205 ( 3.2A)
MIY  A1204 (-4.2A)
MIY  A1204 (-4.4A)
MIY  A1204 ( 4.7A)
 0.93A 2o7oA-4ac0A:
26.1		 2o7oA-4ac0A:
65.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TCT_A_CTCA222_0
(TETRACYCLINE
REPRESSOR)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		6 / 12 HIS A  64
PHE A  86
HIS A 100
ARG A 104
PRO A 105
GLN A 109
 MIY  A1204 (-3.8A)
MIY  A1204 (-3.5A)
MG  A1205 ( 3.2A)
MIY  A1204 (-4.2A)
MIY  A1204 (-4.4A)
MIY  A1204 (-3.9A)
 0.86A 2tctA-4ac0A:
26.1		 2tctA-4ac0A:
64.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TCT_A_CTCA222_0
(TETRACYCLINE
REPRESSOR)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		7 / 12 HIS A  64
PHE A  86
HIS A 100
PRO A 105
GLN A 109
THR A 112
GLN A 116
 MIY  A1204 (-3.8A)
MIY  A1204 (-3.5A)
MG  A1205 ( 3.2A)
MIY  A1204 (-4.4A)
MIY  A1204 (-3.9A)
MIY  A1204 ( 4.7A)
MIY  A1204 (-2.8A)
 0.52A 2tctA-4ac0A:
26.1		 2tctA-4ac0A:
64.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		6 / 11 HIS A  64
ASN A  82
PHE A  86
HIS A 100
ARG A 104
PRO A 105
 MIY  A1204 (-3.8A)
MIY  A1204 (-3.0A)
MIY  A1204 (-3.5A)
MG  A1205 ( 3.2A)
MIY  A1204 (-4.2A)
MIY  A1204 (-4.4A)
 0.87A 2trtA-4ac0A:
26.1		 2trtA-4ac0A:
61.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		6 / 11 HIS A  64
ASN A  82
PHE A  86
HIS A 100
PRO A 105
GLN A 116
 MIY  A1204 (-3.8A)
MIY  A1204 (-3.0A)
MIY  A1204 (-3.5A)
MG  A1205 ( 3.2A)
MIY  A1204 (-4.4A)
MIY  A1204 (-2.8A)
 0.41A 2trtA-4ac0A:
26.1		 2trtA-4ac0A:
61.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VKE_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		6 / 11 HIS A  64
ASN A  82
PHE A  86
HIS A 100
PRO A 105
GLN A 116
 MIY  A1204 (-3.8A)
MIY  A1204 (-3.0A)
MIY  A1204 (-3.5A)
MG  A1205 ( 3.2A)
MIY  A1204 (-4.4A)
MIY  A1204 (-2.8A)
 0.38A 2vkeA-4ac0A:
26.2		 2vkeA-4ac0A:
65.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VKE_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		5 / 11 HIS A  64
PHE A  86
HIS A 100
ARG A 104
PRO A 105
 MIY  A1204 (-3.8A)
MIY  A1204 (-3.5A)
MG  A1205 ( 3.2A)
MIY  A1204 (-4.2A)
MIY  A1204 (-4.4A)
 0.94A 2vkeA-4ac0A:
26.2		 2vkeA-4ac0A:
65.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		7 / 12 HIS A  64
ASN A  82
PHE A  86
HIS A 100
PRO A 105
THR A 112
GLN A 116
 MIY  A1204 (-3.8A)
MIY  A1204 (-3.0A)
MIY  A1204 (-3.5A)
MG  A1205 ( 3.2A)
MIY  A1204 (-4.4A)
MIY  A1204 ( 4.7A)
MIY  A1204 (-2.8A)
 0.43A 2xpvA-4ac0A:
26.5		 2xpvA-4ac0A:
65.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		6 / 12 HIS A  64
PHE A  86
HIS A 100
ARG A 104
PRO A 105
THR A 112
 MIY  A1204 (-3.8A)
MIY  A1204 (-3.5A)
MG  A1205 ( 3.2A)
MIY  A1204 (-4.2A)
MIY  A1204 (-4.4A)
MIY  A1204 ( 4.7A)
 0.86A 2xpvA-4ac0A:
26.5		 2xpvA-4ac0A:
65.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		7 / 12 LEU A  60
HIS A  64
ASN A  82
PHE A  86
HIS A 100
ARG A 104
PRO A 105
 MIY  A1204 ( 4.9A)
MIY  A1204 (-3.8A)
MIY  A1204 (-3.0A)
MIY  A1204 (-3.5A)
MG  A1205 ( 3.2A)
MIY  A1204 (-4.2A)
MIY  A1204 (-4.4A)
 0.83A 2xpwA-4ac0A:
25.6		 2xpwA-4ac0A:
65.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		7 / 12 LEU A  60
HIS A  64
ASN A  82
PHE A  86
HIS A 100
PRO A 105
GLN A 116
 MIY  A1204 ( 4.9A)
MIY  A1204 (-3.8A)
MIY  A1204 (-3.0A)
MIY  A1204 (-3.5A)
MG  A1205 ( 3.2A)
MIY  A1204 (-4.4A)
MIY  A1204 (-2.8A)
 0.42A 2xpwA-4ac0A:
25.6		 2xpwA-4ac0A:
65.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		8 / 12 HIS A  64
ASN A  82
PHE A  86
HIS A 100
PRO A 105
THR A 112
GLN A 116
LEU A 117
 MIY  A1204 (-3.8A)
MIY  A1204 (-3.0A)
MIY  A1204 (-3.5A)
MG  A1205 ( 3.2A)
MIY  A1204 (-4.4A)
MIY  A1204 ( 4.7A)
MIY  A1204 (-2.8A)
None
 0.54A 2xrlA-4ac0A:
25.8		 2xrlA-4ac0A:
64.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		3 / 3 PRO A 105
GLU A 111
TYR A 110
 MIY  A1204 (-4.4A)
None
None
 0.58A 2zmbA-4ac0A:
undetectable		 2zmbA-4ac0A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		4 / 4 LEU A  14
ARG A  49
LEU A  51
ALA A  56
 None
 1.16A 3b9mA-4ac0A:
4.1		 3b9mA-4ac0A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		4 / 5 LEU A   4
LEU A  34
GLY A  35
THR A  40
 None
 0.80A 3si7C-4ac0A:
undetectable
3si7D-4ac0A:
undetectable		 3si7C-4ac0A:
23.10
3si7D-4ac0A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		4 / 5 LEU A  52
LEU A  25
GLY A  24
GLY A  21
 None
 0.81A 3si7C-4ac0A:
undetectable
3si7D-4ac0A:
undetectable		 3si7C-4ac0A:
23.10
3si7D-4ac0A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		5 / 12 LEU A  60
LEU A 113
LEU A  79
ALA A 130
ALA A 133
 MIY  A1204 ( 4.9A)
MIY  A1204 (-4.9A)
None
None
None
 1.07A 3vw7A-4ac0A:
undetectable		 3vw7A-4ac0A:
18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		9 / 12 HIS A  64
ASN A  82
PHE A  86
HIS A 100
PRO A 105
GLN A 109
THR A 112
GLN A 116
LEU A 131
 MIY  A1204 (-3.8A)
MIY  A1204 (-3.0A)
MIY  A1204 (-3.5A)
MG  A1205 ( 3.2A)
MIY  A1204 (-4.4A)
MIY  A1204 (-3.9A)
MIY  A1204 ( 4.7A)
MIY  A1204 (-2.8A)
MIY  A1204 (-4.3A)
 0.53A 4abzA-4ac0A:
26.1		 4abzA-4ac0A:
65.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		7 / 12 PHE A  86
ARG A 104
PRO A 105
GLN A 109
THR A 112
GLN A 116
LEU A 131
 MIY  A1204 (-3.5A)
MIY  A1204 (-4.2A)
MIY  A1204 (-4.4A)
MIY  A1204 (-3.9A)
MIY  A1204 ( 4.7A)
MIY  A1204 (-2.8A)
MIY  A1204 (-4.3A)
 0.83A 4abzA-4ac0A:
26.1		 4abzA-4ac0A:
65.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		7 / 12 LEU A  60
HIS A  64
ASN A  82
PHE A  86
ARG A 104
PRO A 105
GLN A 109
 MIY  A1204 ( 4.9A)
MIY  A1204 (-3.8A)
MIY  A1204 (-3.0A)
MIY  A1204 (-3.5A)
MIY  A1204 (-4.2A)
MIY  A1204 (-4.4A)
MIY  A1204 (-3.9A)
 0.88A 4b3aA-4ac0A:
26.4		 4b3aA-4ac0A:
64.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		7 / 12 LEU A  60
HIS A  64
ASN A  82
PHE A  86
PRO A 105
GLN A 109
GLN A 116
 MIY  A1204 ( 4.9A)
MIY  A1204 (-3.8A)
MIY  A1204 (-3.0A)
MIY  A1204 (-3.5A)
MIY  A1204 (-4.4A)
MIY  A1204 (-3.9A)
MIY  A1204 (-2.8A)
 0.42A 4b3aA-4ac0A:
26.4		 4b3aA-4ac0A:
64.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V2G_B_CTCB222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		8 / 12 HIS A  64
ASN A  82
PHE A  86
HIS A 100
ARG A 104
PRO A 105
THR A 112
GLN A 116
 MIY  A1204 (-3.8A)
MIY  A1204 (-3.0A)
MIY  A1204 (-3.5A)
MG  A1205 ( 3.2A)
MIY  A1204 (-4.2A)
MIY  A1204 (-4.4A)
MIY  A1204 ( 4.7A)
MIY  A1204 (-2.8A)
 0.80A 4v2gB-4ac0A:
25.8		 4v2gB-4ac0A:
65.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0
(Escherichia
coli) 		3 / 3 LEU A 117
LEU A 120
TRP A  75
 None
 0.90A 5nwuA-4ac0A:
undetectable		 5nwuA-4ac0A:
12.02