SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ac1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		5 / 11 LEU X  27
LYS X  33
ILE X  35
VAL X  80
MET X  75
 None
None
None
ACT  X1290 (-4.3A)
None
 1.38A 1gx9A-4ac1X:
undetectable		 1gx9A-4ac1X:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		4 / 4 ILE X 234
LEU X 239
VAL X 279
ALA X  36
 None
None
None
ACT  X1290 (-4.4A)
 0.84A 1mz9A-4ac1X:
undetectable		 1mz9A-4ac1X:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		4 / 5 ILE X 234
LEU X 239
VAL X 279
ALA X  36
 None
None
None
ACT  X1290 (-4.4A)
 0.79A 1mz9C-4ac1X:
undetectable		 1mz9C-4ac1X:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		8 / 9 TYR X  12
GLY X  88
ALA X  89
ASP X 129
GLU X 131
GLN X 193
TYR X 195
TRP X 259
 ACT  X1288 ( 4.1A)
ZN  X1291 ( 4.5A)
None
ACT  X1288 (-2.9A)
ZN  X1291 (-2.5A)
ZN  X1294 ( 2.5A)
ACT  X1288 (-4.7A)
ACT  X1288 (-4.0A)
 0.68A 2uy4A-4ac1X:
22.2		 2uy4A-4ac1X:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		8 / 11 TYR X  12
GLY X  88
ALA X  89
ASP X 129
GLU X 131
GLN X 193
TYR X 195
TRP X 259
 ACT  X1288 ( 4.1A)
ZN  X1291 ( 4.5A)
None
ACT  X1288 (-2.9A)
ZN  X1291 (-2.5A)
ZN  X1294 ( 2.5A)
ACT  X1288 (-4.7A)
ACT  X1288 (-4.0A)
 0.65A 2xtkA-4ac1X:
23.2		 2xtkA-4ac1X:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		8 / 10 TYR X  12
GLY X  88
ALA X  89
ASP X 129
GLU X 131
GLN X 193
TYR X 195
TRP X 259
 ACT  X1288 ( 4.1A)
ZN  X1291 ( 4.5A)
None
ACT  X1288 (-2.9A)
ZN  X1291 (-2.5A)
ZN  X1294 ( 2.5A)
ACT  X1288 (-4.7A)
ACT  X1288 (-4.0A)
 0.66A 2xtkB-4ac1X:
23.2		 2xtkB-4ac1X:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		3 / 3 PRO X 217
GLU X 166
TYR X 207
 None
 0.82A 2zmbA-4ac1X:
undetectable		 2zmbA-4ac1X:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		4 / 6 ILE X 234
SER X 238
LEU X 239
THR X 242
 None
 0.61A 3deuB-4ac1X:
undetectable		 3deuB-4ac1X:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IIZ_A_SAMA1501_0
(BIOTIN SYNTHETASE,
PUTATIVE)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		5 / 12 TYR X 195
GLN X  14
SER X  44
GLY X  88
MET X 257
 ACT  X1288 (-4.7A)
None
None
ZN  X1291 ( 4.5A)
ACT  X1288 ( 4.9A)
 1.45A 3iizA-4ac1X:
5.5		 3iizA-4ac1X:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		4 / 8 SER X  44
HIS X  46
ASP X  57
GLU X 260
 None
 1.06A 3sg9B-4ac1X:
undetectable		 3sg9B-4ac1X:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		4 / 8 ILE X 139
LEU X 142
VAL X  86
GLY X  87
 None
 0.90A 3w1wA-4ac1X:
undetectable		 3w1wA-4ac1X:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		5 / 11 GLY X  88
ASP X 129
GLU X 131
TYR X 195
TRP X 259
 ZN  X1291 ( 4.5A)
ACT  X1288 (-2.9A)
ZN  X1291 (-2.5A)
ACT  X1288 (-4.7A)
ACT  X1288 (-4.0A)
 0.57A 3wqvA-4ac1X:
21.7		 3wqvA-4ac1X:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		5 / 11 GLY X  88
ASP X 129
GLU X 131
TYR X 195
TRP X 259
 ZN  X1291 ( 4.5A)
ACT  X1288 (-2.9A)
ZN  X1291 (-2.5A)
ACT  X1288 (-4.7A)
ACT  X1288 (-4.0A)
 0.57A 3wqwA-4ac1X:
21.6		 3wqwA-4ac1X:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		3 / 3 GLN X 132
ASP X 129
GLN X 193
 None
ACT  X1288 (-2.9A)
ZN  X1294 ( 2.5A)
 0.86A 4aztA-4ac1X:
undetectable		 4aztA-4ac1X:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		4 / 6 GLN X 132
ASP X 129
GLN X 193
GLU X 260
 None
ACT  X1288 (-2.9A)
ZN  X1294 ( 2.5A)
None
 1.49A 4azvA-4ac1X:
undetectable		 4azvA-4ac1X:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		4 / 5 LEU X 246
ILE X 210
ALA X 222
PHE X 194
 None
 1.07A 4dc3B-4ac1X:
2.5		 4dc3B-4ac1X:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JXC_A_SAMA402_0
(FEFE-HYDROGENASE
MATURASE)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		5 / 12 TYR X 195
GLN X  14
SER X  44
GLY X  88
MET X 257
 ACT  X1288 (-4.7A)
None
None
ZN  X1291 ( 4.5A)
ACT  X1288 ( 4.9A)
 1.46A 4jxcA-4ac1X:
6.2		 4jxcA-4ac1X:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		5 / 12 TYR X 195
GLN X  14
SER X  44
GLY X  88
MET X 257
 ACT  X1288 (-4.7A)
None
None
ZN  X1291 ( 4.5A)
ACT  X1288 ( 4.9A)
 1.49A 5fepA-4ac1X:
6.6		 5fepA-4ac1X:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		5 / 12 TYR X 195
GLN X  14
SER X  44
GLY X  88
MET X 257
 ACT  X1288 (-4.7A)
None
None
ZN  X1291 ( 4.5A)
ACT  X1288 ( 4.9A)
 1.47A 5fesA-4ac1X:
6.3		 5fesA-4ac1X:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		4 / 8 GLY X  88
GLU X 131
TYR X 195
TRP X 259
 ZN  X1291 ( 4.5A)
ZN  X1291 (-2.5A)
ACT  X1288 (-4.7A)
ACT  X1288 (-4.0A)
 0.54A 5gqbA-4ac1X:
10.6		 5gqbA-4ac1X:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		5 / 12 VAL X  53
MET X 126
ALA X 159
PHE X  94
LEU X  99
 None
None
ACT  X1288 ( 4.2A)
None
None
 1.20A 5tudD-4ac1X:
undetectable		 5tudD-4ac1X:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		4 / 5 THR X  72
ASN X  70
TRP X  69
LEU X  55
 None
NAG  X 302 (-1.8A)
None
None
 1.48A 5vkqA-4ac1X:
0.6
5vkqB-4ac1X:
0.6		 5vkqA-4ac1X:
9.93
5vkqB-4ac1X:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		4 / 5 THR X  72
ASN X  70
TRP X  69
LEU X  55
 None
NAG  X 302 (-1.8A)
None
None
 1.47A 5vkqC-4ac1X:
0.6
5vkqD-4ac1X:
0.6		 5vkqC-4ac1X:
9.93
5vkqD-4ac1X:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		4 / 6 ILE X 210
ALA X 222
MET X 257
ASP X 129
 None
None
ACT  X1288 ( 4.9A)
ACT  X1288 (-2.9A)
 1.07A 6hu9m-4ac1X:
undetectable
6hu9q-4ac1X:
undetectable		 6hu9m-4ac1X:
19.55
6hu9q-4ac1X:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		3 / 3 TRP X 189
ILE X 187
ASP X 188
 None
 0.75A 6i0y7-4ac1X:
undetectable		 6i0y7-4ac1X:
6.15