SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ac3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 4ac3 BIFUNCTIONAL PROTEIN
GLMU
(Streptococcus
pneumoniae) 		4 / 6 GLU A 182
LEU A 184
VAL A  82
MET A  83
 None
 0.86A 1hk1A-4ac3A:
undetectable		 1hk1A-4ac3A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4ac3 BIFUNCTIONAL PROTEIN
GLMU
(Streptococcus
pneumoniae) 		5 / 12 THR A 129
GLY A 171
GLY A  77
GLU A 195
ILE A 152
 None
 1.00A 2fk8A-4ac3A:
undetectable		 2fk8A-4ac3A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 4ac3 BIFUNCTIONAL PROTEIN
GLMU
(Streptococcus
pneumoniae) 		5 / 9 ALA A 339
ALA A 307
GLY A 306
GLY A 304
ILE A 303
 None
 1.19A 2v7bA-4ac3A:
undetectable		 2v7bA-4ac3A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 4ac3 BIFUNCTIONAL PROTEIN
GLMU
(Streptococcus
pneumoniae) 		5 / 9 ALA A 339
ALA A 307
GLY A 306
GLY A 304
ILE A 303
 None
 1.16A 2v7bB-4ac3A:
undetectable		 2v7bB-4ac3A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4ac3 BIFUNCTIONAL PROTEIN
GLMU
(Streptococcus
pneumoniae) 		5 / 12 ALA A 410
PRO A 411
THR A 364
PHE A 377
ILE A 396
 None
 1.25A 2v95A-4ac3A:
undetectable		 2v95A-4ac3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4ac3 BIFUNCTIONAL PROTEIN
GLMU
(Streptococcus
pneumoniae) 		5 / 10 VAL A 323
SER A 312
ASN A 345
VAL A 347
GLY A 361
 None
 1.46A 2x2iD-4ac3A:
undetectable		 2x2iD-4ac3A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 4ac3 BIFUNCTIONAL PROTEIN
GLMU
(Streptococcus
pneumoniae) 		4 / 5 VAL A 149
VAL A 142
THR A 216
ARG A 151
 None
 1.17A 3bjwA-4ac3A:
undetectable		 3bjwA-4ac3A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 4ac3 BIFUNCTIONAL PROTEIN
GLMU
(Streptococcus
pneumoniae) 		4 / 5 VAL A 149
VAL A 142
THR A 216
ARG A 151
 None
 1.21A 3bjwC-4ac3A:
undetectable		 3bjwC-4ac3A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 4ac3 BIFUNCTIONAL PROTEIN
GLMU
(Streptococcus
pneumoniae) 		5 / 12 LEU A 292
ALA A 329
GLY A 295
VAL A 266
ILE A 286
 None
 1.06A 3c6gA-4ac3A:
undetectable		 3c6gA-4ac3A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB315_0
(UNCHARACTERIZED
PROTEIN)		 4ac3 BIFUNCTIONAL PROTEIN
GLMU
(Streptococcus
pneumoniae) 		5 / 12 THR A 383
ILE A 396
THR A 394
PHE A 377
VAL A 349
 None
 1.19A 3ijdB-4ac3A:
0.0		 3ijdB-4ac3A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 4ac3 BIFUNCTIONAL PROTEIN
GLMU
(Streptococcus
pneumoniae) 		5 / 9 VAL A 341
ILE A 354
THR A 383
VAL A 347
VAL A 349
 None
 1.21A 3me6D-4ac3A:
undetectable		 3me6D-4ac3A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 4ac3 BIFUNCTIONAL PROTEIN
GLMU
(Streptococcus
pneumoniae) 		5 / 12 LEU A 292
GLY A 306
ALA A 307
VAL A 325
ILE A 309
 None
 0.99A 3tkgD-4ac3A:
undetectable		 3tkgD-4ac3A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4ac3 BIFUNCTIONAL PROTEIN
GLMU
(Streptococcus
pneumoniae) 		3 / 3 THR A 310
VAL A 308
GLU A 275
 None
 0.60A 3v4tA-4ac3A:
undetectable
3v4tD-4ac3A:
undetectable		 3v4tA-4ac3A:
23.73
3v4tD-4ac3A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4ac3 BIFUNCTIONAL PROTEIN
GLMU
(Streptococcus
pneumoniae) 		4 / 6 GLU A 210
HIS A  95
VAL A  98
PHE A 205
 None
 1.20A 4a97E-4ac3A:
undetectable		 4a97E-4ac3A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4ac3 BIFUNCTIONAL PROTEIN
GLMU
(Streptococcus
pneumoniae) 		4 / 8 GLY A 171
ILE A 127
ILE A 152
THR A 199
 None
 0.76A 4em2A-4ac3A:
undetectable		 4em2A-4ac3A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 4ac3 BIFUNCTIONAL PROTEIN
GLMU
(Streptococcus
pneumoniae) 		5 / 10 ILE A  99
ILE A   6
ALA A   5
THR A  48
LEU A  33
 None
 1.32A 4kq8A-4ac3A:
undetectable		 4kq8A-4ac3A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 4ac3 BIFUNCTIONAL PROTEIN
GLMU
(Streptococcus
pneumoniae) 		4 / 7 LEU A 128
LEU A  97
ILE A 198
VAL A  82
 None
 0.77A 4ojbA-4ac3A:
undetectable		 4ojbA-4ac3A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4ac3 BIFUNCTIONAL PROTEIN
GLMU
(Streptococcus
pneumoniae) 		3 / 3 ASP A 219
LEU A 217
PHE A 220
 None
 0.64A 4pthA-4ac3A:
undetectable		 4pthA-4ac3A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4ac3 BIFUNCTIONAL PROTEIN
GLMU
(Streptococcus
pneumoniae) 		5 / 11 ILE A 286
VAL A 298
THR A 296
ILE A 309
ALA A 307
 None
 1.12A 5lg3A-4ac3A:
undetectable		 5lg3A-4ac3A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 4ac3 BIFUNCTIONAL PROTEIN
GLMU
(Streptococcus
pneumoniae) 		4 / 5 ILE A   6
GLN A  72
THR A  67
LEU A  33
 None
 1.13A 6f3mD-4ac3A:
undetectable		 6f3mD-4ac3A:
23.38