SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4aca'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
4 / 7 PHE A 186
VAL A 248
GLY A 249
VAL A 229
None
0.90A 1t88A-4acaA:
undetectable
1t88A-4acaA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
4 / 4 VAL A  90
LEU A  85
ILE A 169
LEU A 168
None
0.93A 2byoA-4acaA:
undetectable
2byoA-4acaA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
4 / 5 SER A 286
GLY A 372
HIS A 103
ASP A  71
CMH  A 371 ( 4.5A)
CMH  A 371 ( 2.4A)
None
None
0.85A 2oxtB-4acaA:
undetectable
2oxtB-4acaA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
5 / 11 LEU A  63
LEU A   8
LEU A  85
THR A 171
VAL A 117
None
1.25A 2qd3A-4acaA:
3.3
2qd3A-4acaA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
5 / 12 LEU A  21
GLY A  17
ILE A 154
ALA A  92
ASP A 122
None
1.06A 3gwwA-4acaA:
undetectable
3gwwA-4acaA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
4 / 5 PHE A 342
ILE A 387
MET A 297
PHE A 315
CMH  A 340 ( 4.2A)
None
None
CMH  A 340 ( 4.6A)
1.35A 3octA-4acaA:
undetectable
3octA-4acaA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
5 / 12 LEU A 140
THR A 172
THR A 171
LEU A  87
ILE A 152
None
1.20A 3sp9A-4acaA:
undetectable
3sp9A-4acaA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
5 / 12 ILE A 387
TRP A 467
ALA A 281
LEU A 301
VAL A 356
None
None
CMH  A 340 ( 4.3A)
None
None
0.98A 3w67C-4acaA:
1.6
3w67C-4acaA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
5 / 12 ILE A 223
ILE A 252
VAL A 229
MET A 188
LEU A 190
None
None
None
None
CMH  A 264 ( 4.1A)
1.21A 4a81A-4acaA:
undetectable
4a81A-4acaA:
17.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
6 / 11 GLY A  50
PHE A  51
VAL A 202
GLN A 233
SER A 238
GLY A 249
None
0.86A 4ac9B-4acaA:
53.7
4ac9C-4acaA:
51.9
4ac9B-4acaA:
100.00
4ac9C-4acaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
6 / 11 PHE A  51
PHE A 194
VAL A 202
GLN A 233
SER A 238
GLY A 249
None
0.65A 4ac9B-4acaA:
53.7
4ac9C-4acaA:
51.9
4ac9B-4acaA:
100.00
4ac9C-4acaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
6 / 7 SER A 121
ASP A 122
GLY A 125
THR A 126
SER A 155
THR A 158
None
0.40A 4ac9C-4acaA:
51.9
4ac9C-4acaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
5 / 7 SER A 121
ASP A 122
SER A 155
THR A 158
PHE A 160
None
0.42A 4ac9C-4acaA:
51.9
4ac9C-4acaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
4 / 5 THR A 126
ILE A 129
LYS A 130
GLU A 133
None
0.63A 4ac9C-4acaA:
51.9
4ac9C-4acaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
6 / 9 GLY A  50
PHE A  51
VAL A 202
THR A 204
GLN A 233
GLY A 249
None
0.79A 4acaB-4acaA:
53.7
4acaC-4acaA:
51.8
4acaB-4acaA:
100.00
4acaC-4acaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
5 / 8 PHE A  51
VAL A 202
SER A 231
GLN A 233
GLY A 249
None
0.55A 4acaC-4acaA:
51.8
4acaC-4acaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
6 / 7 SER A 121
ASP A 122
GLY A 125
THR A 126
ILE A 129
THR A 158
None
0.42A 4acaC-4acaA:
51.8
4acaC-4acaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
5 / 7 SER A 121
ASP A 122
ILE A 129
THR A 158
PHE A 160
None
0.53A 4acaC-4acaA:
51.8
4acaC-4acaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
4 / 5 ILE A 129
LYS A 130
GLU A 133
PHE A 160
None
0.79A 4acaC-4acaA:
51.8
4acaC-4acaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
4 / 5 THR A 126
ILE A 129
LYS A 130
GLU A 133
None
0.66A 4acaC-4acaA:
51.8
4acaC-4acaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
4 / 8 PHE A  51
SER A 231
GLN A 233
GLY A 249
None
0.50A 4acbC-4acaA:
51.7
4acbC-4acaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
4 / 8 PHE A  51
VAL A 202
GLN A 233
GLY A 249
None
0.53A 4acbC-4acaA:
51.7
4acbC-4acaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
5 / 6 SER A 121
ASP A 122
ILE A 129
THR A 158
PHE A 160
None
0.55A 4acbC-4acaA:
51.7
4acbC-4acaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
5 / 6 SER A 121
ASP A 122
THR A 126
ILE A 129
THR A 158
None
0.48A 4acbC-4acaA:
51.7
4acbC-4acaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
4 / 5 ILE A 129
LYS A 130
GLU A 133
PHE A 160
None
0.78A 4acbC-4acaA:
51.7
4acbC-4acaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
5 / 12 ALA A  75
SER A  78
VAL A  77
ILE A 307
HIS A  69
None
1.22A 4c49A-4acaA:
undetectable
4c49A-4acaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
5 / 12 LEU A  63
LEU A   8
LEU A  85
THR A 171
VAL A 117
None
1.19A 4f4dA-4acaA:
undetectable
4f4dA-4acaA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
4 / 4 LEU A   8
ARG A 180
ILE A   6
ILE A 178
None
1.25A 5dzk2-4acaA:
undetectable
5dzkM-4acaA:
undetectable
5dzkN-4acaA:
undetectable
5dzk2-4acaA:
0.44
5dzkM-4acaA:
18.48
5dzkN-4acaA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
4 / 4 ILE A   6
ILE A 178
ARG A 180
LEU A   8
None
1.14A 5dzkh-4acaA:
undetectable
5dzkn-4acaA:
undetectable
5dzkv-4acaA:
undetectable
5dzkh-4acaA:
18.48
5dzkn-4acaA:
18.48
5dzkv-4acaA:
0.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
4 / 4 ILE A   6
ILE A 178
ARG A 180
LEU A  85
None
1.35A 5dzkh-4acaA:
undetectable
5dzkn-4acaA:
undetectable
5dzkv-4acaA:
undetectable
5dzkh-4acaA:
18.48
5dzkn-4acaA:
18.48
5dzkv-4acaA:
0.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis)
3 / 3 LYS A 187
ASN A 208
SER A  78
None
1.25A 5yw0A-4acaA:
undetectable
5yw0A-4acaA:
20.53