SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4acj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)
4acj WU:FB25H12 PROTEIN,
(Danio
rerio)
5 / 12 LEU A 724
PHE A 753
PHE A 710
ALA A 704
THR A 778
None
1.06A 1ao8A-4acjA:
undetectable
1ao8A-4acjA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)
4acj WU:FB25H12 PROTEIN,
(Danio
rerio)
3 / 3 GLU A 796
ALA A 666
SER A 799
None
0.58A 1errB-4acjA:
undetectable
1errB-4acjA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))
4acj WU:FB25H12 PROTEIN,
(Danio
rerio)
5 / 9 ARG A 657
GLU A 721
ALA A 706
LEU A 705
PRO A 655
None
1.46A 1mj2A-4acjA:
undetectable
1mj2A-4acjA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))
4acj WU:FB25H12 PROTEIN,
(Danio
rerio)
5 / 9 ARG A 657
GLU A 721
ALA A 706
LEU A 705
PRO A 655
None
1.45A 1mj2C-4acjA:
undetectable
1mj2C-4acjA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)
4acj WU:FB25H12 PROTEIN,
(Danio
rerio)
5 / 9 ARG A 657
GLU A 721
ALA A 706
LEU A 705
PRO A 655
None
1.48A 1mjoA-4acjA:
undetectable
1mjoA-4acjA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)
4acj WU:FB25H12 PROTEIN,
(Danio
rerio)
5 / 9 ARG A 657
GLU A 721
ALA A 706
LEU A 705
PRO A 655
None
1.47A 1mjoB-4acjA:
undetectable
1mjoB-4acjA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)
4acj WU:FB25H12 PROTEIN,
(Danio
rerio)
5 / 9 ARG A 657
GLU A 721
ALA A 706
LEU A 705
PRO A 655
None
1.46A 1mjoC-4acjA:
undetectable
1mjoC-4acjA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)
4acj WU:FB25H12 PROTEIN,
(Danio
rerio)
4 / 7 GLU A 796
ILE A 701
TRP A 798
LEU A 691
None
1.45A 1q0yH-4acjA:
undetectable
1q0yL-4acjA:
undetectable
1q0yH-4acjA:
21.65
1q0yL-4acjA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PK4_A_ACAA100_1
(HUMAN PLASMINOGEN
KRINGLE 4)
4acj WU:FB25H12 PROTEIN,
(Danio
rerio)
4 / 7 LYS A 745
ASP A 747
ASP A 749
PHE A 760
None
1.02A 2pk4A-4acjA:
undetectable
2pk4A-4acjA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)
4acj WU:FB25H12 PROTEIN,
(Danio
rerio)
5 / 12 LEU A 724
PHE A 779
LEU A 784
ILE A 744
SER A 785
None
1.36A 2pnjB-4acjA:
undetectable
2pnjB-4acjA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)
4acj WU:FB25H12 PROTEIN,
(Danio
rerio)
4 / 6 LYS A 652
LEU A 654
PHE A 800
LEU A 691
None
1.22A 5x19P-4acjA:
undetectable
5x19P-4acjA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)
4acj WU:FB25H12 PROTEIN,
(Danio
rerio)
5 / 12 ILE A 694
LEU A 692
PHE A 702
SER A 785
LEU A 751
None
1.23A 6b52A-4acjA:
undetectable
6b52A-4acjA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)
4acj WU:FB25H12 PROTEIN,
(Danio
rerio)
5 / 11 TYR A 717
PHE A 710
ALA A 704
THR A 722
THR A 719
None
1.43A 6efnA-4acjA:
undetectable
6efnA-4acjA:
17.19