SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ack'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ack TSSL
(Francisella
tularensis) 		4 / 5 PHE A 132
GLY A 100
THR A 107
PHE A 104
 None
EDO  A1157 ( 3.8A)
None
None
 1.22A 1icuC-4ackA:
undetectable
1icuD-4ackA:
undetectable		 1icuC-4ackA:
21.49
1icuD-4ackA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ack TSSL
(Francisella
tularensis) 		4 / 7 ILE A  61
LEU A  49
TYR A  94
ARG A  96
 None
 1.22A 2zxwN-4ackA:
undetectable
2zxwW-4ackA:
undetectable		 2zxwN-4ackA:
14.31
2zxwW-4ackA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4ack TSSL
(Francisella
tularensis) 		5 / 12 LEU A  66
GLN A  90
SER A  41
ILE A  38
ARG A  35
 None
None
BR  A1156 (-3.1A)
BR  A1156 ( 4.8A)
None
 1.35A 3ia4A-4ackA:
undetectable		 3ia4A-4ackA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 4ack TSSL
(Francisella
tularensis) 		3 / 3 GLU A   8
LEU A  11
ASP A  12
 None
None
BR  A1156 ( 4.4A)
 0.45A 3ko0A-4ackA:
undetectable		 3ko0A-4ackA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 4ack TSSL
(Francisella
tularensis) 		3 / 3 GLU A   8
LEU A  11
ASP A  12
 None
None
BR  A1156 ( 4.4A)
 0.37A 3ko0T-4ackA:
undetectable		 3ko0T-4ackA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 4ack TSSL
(Francisella
tularensis) 		4 / 7 PHE A 132
GLY A 100
THR A 107
PHE A  63
 None
EDO  A1157 ( 3.8A)
None
None
 1.08A 3vnsA-4ackA:
undetectable		 3vnsA-4ackA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4ack TSSL
(Francisella
tularensis) 		4 / 5 LEU A  50
TYR A  53
LYS A  52
GLU A   6
 None
 1.32A 5weaA-4ackA:
undetectable		 5weaA-4ackA:
11.76