SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4aco'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_A_STRA1_1
(PROGESTERONE
RECEPTOR)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 186
LEU A 185
GLN A 219
LEU A 534
CYH A 349
 None
 1.48A 1a28A-4acoA:
undetectable		 1a28A-4acoA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 312
ASP A 320
ASP A 456
 None
 0.76A 1eizA-4acoA:
undetectable		 1eizA-4acoA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 312
ASP A 320
ASP A 456
 None
 0.74A 1ej0A-4acoA:
undetectable		 1ej0A-4acoA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  53
LEU A 132
ASN A 130
ASN A 141
ILE A 146
 None
 1.02A 2nnhA-4acoA:
undetectable		 2nnhA-4acoA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		5 / 10 ILE A  53
LEU A 132
ASN A 130
ASN A 141
ILE A 146
 None
 1.00A 2nnhB-4acoA:
undetectable		 2nnhB-4acoA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 215
LEU A 290
ALA A 287
LEU A 272
CYH A 281
 None
 1.31A 2oaxE-4acoA:
undetectable		 2oaxE-4acoA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 342
PHE A 338
PHE A 205
PRO A 333
THR A 285
 None
 1.32A 2x2nA-4acoA:
undetectable		 2x2nA-4acoA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  90
ILE A 406
LYS A 410
SER A 411
PRO A 412
 None
 1.19A 3bjwB-4acoA:
undetectable		 3bjwB-4acoA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 322
PHE A 228
LYS A 233
 None
 1.26A 3bjwG-4acoA:
undetectable		 3bjwG-4acoA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  90
ILE A 406
LYS A 410
SER A 411
PRO A 412
 None
 1.17A 3bjwH-4acoA:
undetectable		 3bjwH-4acoA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 312
ASP A 320
ASP A 456
 None
 0.75A 3douA-4acoA:
undetectable		 3douA-4acoA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 359
GLU A 229
SER A 232
ARG A 355
 None
 1.37A 3dqtA-4acoA:
undetectable
3dqtB-4acoA:
undetectable		 3dqtA-4acoA:
16.51
3dqtB-4acoA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 143
ILE A 126
GLY A 127
ASN A 145
THR A 148
 None
 1.15A 3eeyA-4acoA:
undetectable		 3eeyA-4acoA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 143
ILE A 126
GLY A 127
ASN A 145
THR A 148
 None
 1.15A 3eeyB-4acoA:
undetectable		 3eeyB-4acoA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 143
ILE A 126
GLY A 127
ASN A 145
THR A 148
 None
 1.15A 3eeyF-4acoA:
undetectable		 3eeyF-4acoA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 143
ILE A 126
GLY A 127
ASN A 145
THR A 148
 None
 1.16A 3eeyH-4acoA:
undetectable		 3eeyH-4acoA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 143
ILE A 126
GLY A 127
ASN A 145
THR A 148
 None
 1.16A 3eeyI-4acoA:
undetectable		 3eeyI-4acoA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		4 / 7 SER A 232
ARG A 355
PHE A 359
GLU A 229
 None
 1.42A 3n5tA-4acoA:
undetectable
3n5tB-4acoA:
undetectable		 3n5tA-4acoA:
16.68
3n5tB-4acoA:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_A_ACTA601_0
(CHOLINE OXIDASE)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		4 / 5 ILE A  94
HIS A 158
VAL A 154
HIS A  86
 None
 1.21A 3nneA-4acoA:
undetectable		 3nneA-4acoA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_B_ACTB601_0
(CHOLINE OXIDASE)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		4 / 5 ILE A  94
HIS A 158
VAL A 154
HIS A  86
 None
 1.17A 3nneB-4acoA:
0.0		 3nneB-4acoA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		4 / 6 ILE A  94
HIS A 158
VAL A 154
HIS A  86
 None
 1.20A 3nneG-4acoA:
undetectable		 3nneG-4acoA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 146
ALA A 144
LEU A  78
LEU A 132
ILE A  85
 None
 1.02A 3tq9A-4acoA:
undetectable		 3tq9A-4acoA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 432
ILE A 484
TYR A 295
TYR A 498
 None
 1.36A 3vt7A-4acoA:
undetectable		 3vt7A-4acoA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 359
GLU A 229
SER A 232
ARG A 355
 None
 1.39A 4k5jA-4acoA:
undetectable
4k5jB-4acoA:
undetectable		 4k5jA-4acoA:
16.70
4k5jB-4acoA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		5 / 7 LEU A 272
ASN A 225
LEU A 224
ARG A 221
LEU A 220
 None
 1.24A 4wg0B-4acoA:
undetectable
4wg0C-4acoA:
undetectable		 4wg0B-4acoA:
1.56
4wg0C-4acoA:
1.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 359
GLU A 229
SER A 232
ARG A 355
 None
 1.37A 5adlA-4acoA:
undetectable
5adlB-4acoA:
undetectable		 5adlA-4acoA:
16.70
5adlB-4acoA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 359
GLU A 229
SER A 232
ARG A 355
 None
 1.36A 5fj3A-4acoA:
undetectable
5fj3B-4acoA:
undetectable		 5fj3A-4acoA:
16.70
5fj3B-4acoA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		4 / 6 CYH A 182
CYH A 349
HIS A 350
LEU A 351
 None
 1.10A 5hpuC-4acoA:
undetectable
5hpuD-4acoA:
undetectable		 5hpuC-4acoA:
2.57
5hpuD-4acoA:
3.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		4 / 7 SER A 189
ILE A 280
LEU A 185
PRO A 282
 None
 0.96A 5u4sA-4acoA:
undetectable		 5u4sA-4acoA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		4 / 6 SER A 232
ARG A 355
PHE A 359
GLU A 229
 None
 1.38A 5uo8A-4acoA:
undetectable
5uo8B-4acoA:
0.0		 5uo8A-4acoA:
17.69
5uo8B-4acoA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 359
GLU A 229
SER A 232
ARG A 355
 None
 1.41A 5vv7A-4acoA:
undetectable
5vv7B-4acoA:
undetectable		 5vv7A-4acoA:
16.70
5vv7B-4acoA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 359
GLU A 229
SER A 232
ARG A 355
 None
 1.39A 5vvnA-4acoA:
undetectable
5vvnB-4acoA:
undetectable		 5vvnA-4acoA:
16.70
5vvnB-4acoA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		4 / 7 SER A 232
ARG A 355
PHE A 359
GLU A 229
 None
 1.34A 6av6A-4acoA:
undetectable
6av6B-4acoA:
undetectable		 6av6A-4acoA:
6.71
6av6B-4acoA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 359
GLU A 229
SER A 232
ARG A 355
 None
 1.41A 6av6C-4acoA:
undetectable
6av6D-4acoA:
undetectable		 6av6C-4acoA:
6.71
6av6D-4acoA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		4 / 7 SER A 232
ARG A 355
PHE A 359
GLU A 229
 None
 1.35A 6av7A-4acoA:
undetectable
6av7B-4acoA:
undetectable		 6av7A-4acoA:
6.71
6av7B-4acoA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 332
LEU A 324
PHE A 205
VAL A 345
LEU A 226
 None
 1.16A 6djzA-4acoA:
undetectable		 6djzA-4acoA:
12.54