SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4acq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_1
(ALCOHOL
DEHYDROGENASE)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		4 / 4 GLU A 160
MET A 151
LEU A 128
SER A 127
 None
 1.44A 1ee2B-4acqA:
undetectable		 1ee2B-4acqA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		5 / 12 LEU A 828
GLN A 843
VAL A 839
ALA A 812
LEU A 796
 None
 1.18A 1gs4A-4acqA:
undetectable		 1gs4A-4acqA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		5 / 11 ALA A 556
LEU A 540
LEU A 461
SER A 525
ILE A 526
 None
 1.04A 1ha2A-4acqA:
2.7		 1ha2A-4acqA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		4 / 7 LEU A 920
MET A1314
GLU A 929
LEU A 931
 None
 1.08A 1linA-4acqA:
undetectable		 1linA-4acqA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		4 / 4 HIS A 479
ALA A 478
PHE A 524
GLY A 522
 None
 1.25A 1mjoA-4acqA:
undetectable		 1mjoA-4acqA:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		4 / 7 THR A1232
THR A1229
SER A1225
VAL A 927
 None
 1.16A 1tv8B-4acqA:
undetectable		 1tv8B-4acqA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		4 / 4 LEU A1046
PRO A1119
ILE A1068
LEU A1070
 None
 1.01A 1ya4C-4acqA:
undetectable		 1ya4C-4acqA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		5 / 10 SER A1026
TRP A1069
ALA A1066
LEU A1067
LEU A1046
 None
 1.14A 2bxqA-4acqA:
undetectable		 2bxqA-4acqA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		4 / 7 THR A1232
THR A1229
SER A1225
VAL A 927
 None
 1.23A 2fb2B-4acqA:
undetectable		 2fb2B-4acqA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		4 / 5 ILE A 505
PHE A  89
VAL A  67
PHE A 678
 None
 1.17A 2ygnA-4acqA:
undetectable		 2ygnA-4acqA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		5 / 10 ILE A 379
GLY A 403
LEU A 404
VAL A 421
ILE A 384
 None
 0.97A 3em4V-4acqA:
undetectable		 3em4V-4acqA:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		4 / 5 LEU A 931
GLN A1325
THR A1326
GLU A 929
 None
 1.44A 3n58C-4acqA:
undetectable		 3n58C-4acqA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		3 / 3 ASN A 566
ALA A 565
LYS A 567
 None
 0.89A 3runA-4acqA:
undetectable		 3runA-4acqA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		3 / 3 PHE A 224
LYS A 135
SER A 136
 None
 1.22A 3tyeB-4acqA:
undetectable		 3tyeB-4acqA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		4 / 8 VAL A 355
HIS A 446
PHE A 407
PRO A 364
 None
None
None
NAG  A2401 (-3.9A)
 1.46A 3v35A-4acqA:
undetectable		 3v35A-4acqA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		5 / 12 PHE A 300
VAL A 266
ILE A 268
TYR A 301
VAL A 304
 None
 0.97A 4a97B-4acqA:
3.5
4a97C-4acqA:
3.5		 4a97B-4acqA:
11.67
4a97C-4acqA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		4 / 6 PHE A 365
ARG A 360
PHE A 359
HIS A 358
 None
 1.23A 4uciA-4acqA:
undetectable		 4uciA-4acqA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		4 / 7 PHE A 155
LEU A 778
SER A 532
VAL A 618
 None
 1.05A 4wnvD-4acqA:
undetectable		 4wnvD-4acqA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		4 / 4 LEU A 468
ARG A 507
ILE A 528
ILE A 499
 None
 1.25A 5dzk2-4acqA:
undetectable
5dzkM-4acqA:
undetectable
5dzkN-4acqA:
undetectable		 5dzk2-4acqA:
12.50
5dzkM-4acqA:
9.29
5dzkN-4acqA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		4 / 4 ILE A 528
ILE A 499
ARG A 507
LEU A 468
 None
 1.19A 5dzkh-4acqA:
undetectable
5dzkn-4acqA:
undetectable
5dzkv-4acqA:
undetectable		 5dzkh-4acqA:
9.29
5dzkn-4acqA:
9.29
5dzkv-4acqA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		3 / 3 LYS A 521
HIS A 523
HIS A 479
 None
 1.21A 5oexA-4acqA:
undetectable		 5oexA-4acqA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		3 / 3 LYS A 521
HIS A 523
HIS A 479
 None
 1.20A 5oexB-4acqA:
undetectable		 5oexB-4acqA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		3 / 3 LYS A 521
HIS A 523
HIS A 479
 None
 1.18A 5oexC-4acqA:
undetectable		 5oexC-4acqA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		3 / 3 LYS A 521
HIS A 523
HIS A 479
 None
 1.16A 5oexD-4acqA:
undetectable		 5oexD-4acqA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		5 / 12 VAL A 551
ASP A 550
ASP A  82
GLY A 485
LEU A 482
 None
 1.08A 6b0iB-4acqA:
undetectable		 6b0iB-4acqA:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		4 / 4 ILE A 528
LEU A 461
HIS A 511
ALA A 478
 None
 0.96A 6ck2C-4acqA:
undetectable
6ck2D-4acqA:
undetectable		 6ck2C-4acqA:
2.61
6ck2D-4acqA:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		5 / 12 THR A1268
VAL A1292
TYR A1264
VAL A1278
GLY A1318
 None
 1.43A 6gngB-4acqA:
undetectable		 6gngB-4acqA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens) 		5 / 11 PHE A 219
GLY A 201
PHE A 192
ILE A 167
ILE A 175
 None
 1.06A 6gp2B-4acqA:
undetectable		 6gp2B-4acqA:
4.77