SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4acz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		3 / 3 LEU B 223
HIS B 185
LYS B 187
 GOL  B1379 (-4.6A)
GOL  B1379 ( 3.8A)
GOL  B1379 (-3.0A)
 0.95A 1y7iA-4aczB:
undetectable		 1y7iA-4aczB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		3 / 3 PHE B 181
PHE B 151
PHE B 190
 None
 0.87A 2od9A-4aczB:
undetectable		 2od9A-4aczB:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		5 / 12 TYR B  91
ILE B 286
ALA B  87
GLY B 333
THR B  96
 None
 1.06A 2okcA-4aczB:
undetectable		 2okcA-4aczB:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASN B 294
ARG B 291
ASP B 194
 None
 0.96A 2qe6A-4aczB:
undetectable		 2qe6A-4aczB:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASN B 294
ARG B 291
ASP B 194
 None
 0.97A 2qe6B-4aczB:
1.8		 2qe6B-4aczB:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		3 / 3 PHE B 181
PHE B 151
PHE B 190
 None
 0.87A 2qqgA-4aczB:
undetectable		 2qqgA-4aczB:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		5 / 11 THR B 218
VAL B 172
ILE B 171
ILE B 168
PRO B 188
 None
 1.24A 3kpcA-4aczB:
undetectable		 3kpcA-4aczB:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		5 / 12 TYR B 285
GLY B 333
GLU B 332
GLY B 282
ASP B 309
 None
 1.14A 3qowA-4aczB:
undetectable		 3qowA-4aczB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLN B 335
PHE B  90
TYR B 352
 None
 0.82A 3ucjB-4aczB:
undetectable		 3ucjB-4aczB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLN B 335
PHE B  90
TYR B 352
 None
 0.85A 3ucjA-4aczB:
undetectable		 3ucjA-4aczB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY B 282
GLY B 333
GLY B 284
HIS B 331
GLU B 332
 None
 0.93A 4ctjC-4aczB:
undetectable		 4ctjC-4aczB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		4 / 7 ARG B 165
TRP B 203
PHE B 207
GLU B 202
 None
 1.44A 4jseA-4aczB:
undetectable
4jseB-4aczB:
0.1		 4jseA-4aczB:
22.22
4jseB-4aczB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLU B 337
TRP B 330
LYS B 107
 None
 1.16A 4k7aA-4aczB:
undetectable		 4k7aA-4aczB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		4 / 6 SER B 121
GLY B 244
ASP B 243
GLY B 226
 None
 0.90A 4koeA-4aczB:
undetectable
4koeB-4aczB:
undetectable
4koeC-4aczB:
undetectable		 4koeA-4aczB:
21.69
4koeB-4aczB:
21.69
4koeC-4aczB:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		4 / 7 SER B 121
GLY B 244
ASP B 243
GLY B 226
 None
 0.89A 4koeA-4aczB:
undetectable
4koeB-4aczB:
undetectable
4koeD-4aczB:
undetectable		 4koeA-4aczB:
21.69
4koeB-4aczB:
21.69
4koeD-4aczB:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		4 / 4 HIS B 331
GLU B 154
HIS B 152
LEU B 120
 None
 1.41A 4m2rA-4aczB:
undetectable		 4m2rA-4aczB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		4 / 8 LEU B 227
GLY B 226
MET B 266
ALA B 270
 None
 0.82A 4rjdA-4aczB:
undetectable
4rjdB-4aczB:
undetectable		 4rjdA-4aczB:
9.86
4rjdB-4aczB:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		4 / 7 PHE B 327
SER B  44
ALA B 115
LEU B 361
 None
 1.12A 4xk8A-4aczB:
undetectable		 4xk8A-4aczB:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		4 / 6 GLY B 244
ASP B 243
GLY B 226
SER B 121
 None
 0.90A 4z53A-4aczB:
undetectable
4z53B-4aczB:
undetectable		 4z53A-4aczB:
20.03
4z53B-4aczB:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		4 / 7 GLY B 244
ASP B 243
GLY B 226
SER B 121
 None
 0.87A 4z53A-4aczB:
undetectable
4z53B-4aczB:
undetectable		 4z53A-4aczB:
20.03
4z53B-4aczB:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		4 / 6 SER B 121
GLY B 244
ASP B 243
GLY B 226
 None
 0.74A 5cdnA-4aczB:
undetectable
5cdnB-4aczB:
undetectable		 5cdnA-4aczB:
21.83
5cdnB-4aczB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		4 / 6 SER B 121
GLY B 244
ASP B 243
GLY B 226
 None
 0.75A 5cdnR-4aczB:
undetectable
5cdnS-4aczB:
undetectable		 5cdnR-4aczB:
21.83
5cdnS-4aczB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		4 / 7 ASP B 129
TYR B 175
SER B  99
ASN B  48
 None
 1.22A 5l1fC-4aczB:
undetectable		 5l1fC-4aczB:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE B 191
ILE B 225
PHE B  45
THR B 255
GLU B 154
 None
 1.17A 5vcgA-4aczB:
undetectable		 5vcgA-4aczB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY B 282
GLY B 333
GLY B 284
HIS B 331
GLU B 332
 None
 0.86A 5wz1B-4aczB:
undetectable		 5wz1B-4aczB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		4 / 6 GLN B 268
TRP B 269
HIS B 273
ALA B 272
 None
 1.40A 6f6jC-4aczB:
undetectable
6f6jD-4aczB:
undetectable		 6f6jC-4aczB:
19.36
6f6jD-4aczB:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 4acz ENDO-ALPHA-MANNOSIDA
SE
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE B 322
VAL B 281
THR B 325
ILE B 324
PHE B 191
 None
 1.18A 6hlpA-4aczB:
undetectable		 6hlpA-4aczB:
21.15