SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ad8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 4ad8 DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		3 / 3 PHE A 470
LEU A 450
SER A 150
 None
 0.86A 1e7aA-4ad8A:
undetectable		 1e7aA-4ad8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 4ad8 DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		5 / 12 ARG A  36
ALA A  73
ASP A  72
ILE A  45
ILE A  39
 None
 0.88A 2b60A-4ad8A:
undetectable		 2b60A-4ad8A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 4ad8 DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		5 / 12 ASP A 474
ASP A 471
ILE A  70
GLY A  66
ALA A 508
 None
 0.82A 2b7zB-4ad8A:
undetectable		 2b7zB-4ad8A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 4ad8 DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		5 / 12 LEU A 489
PHE A  56
LEU A 492
SER A 458
LEU A 154
 None
 1.32A 2qd4A-4ad8A:
undetectable		 2qd4A-4ad8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 4ad8 DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		3 / 3 ARG A 496
ARG A  33
PRO A  32
 None
 0.97A 2wljA-4ad8A:
3.0		 2wljA-4ad8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4ad8 DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		5 / 12 ILE A 398
LEU A 461
LEU A 390
LEU A 428
VAL A 453
 None
 1.03A 3ix9A-4ad8A:
undetectable		 3ix9A-4ad8A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4ad8 DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		5 / 12 ILE A 398
LEU A 461
LEU A 390
LEU A 428
VAL A 453
 None
 1.06A 3ix9B-4ad8A:
undetectable		 3ix9B-4ad8A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4ad8 DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		4 / 8 VAL A 530
LEU A  50
LEU A  48
ILE A  70
 None
 0.93A 3u5kD-4ad8A:
undetectable		 3u5kD-4ad8A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 4ad8 DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		5 / 12 ARG A 510
ILE A 483
THR A  60
THR A 459
ALA A 493
 None
 1.30A 3ua1A-4ad8A:
undetectable		 3ua1A-4ad8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4ad8 DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		5 / 9 GLY A 479
ALA A 482
ALA A 475
ASP A 474
ARG A 452
 None
 1.13A 3ur0C-4ad8A:
undetectable		 3ur0C-4ad8A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 4ad8 DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		4 / 5 GLU A 339
GLY A 341
TYR A 330
GLN A 209
 None
 1.49A 3w9tD-4ad8A:
undetectable		 3w9tD-4ad8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 4ad8 DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		4 / 5 GLU A 339
GLY A 341
TYR A 330
GLN A 209
 None
 1.48A 3w9tE-4ad8A:
undetectable		 3w9tE-4ad8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 4ad8 DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		4 / 5 GLU A 339
GLY A 341
TYR A 330
GLN A 209
 None
 1.46A 3w9tG-4ad8A:
undetectable		 3w9tG-4ad8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 4ad8 DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		3 / 3 ARG A 383
ASP A 165
TYR A 175
 None
 0.82A 4yo9B-4ad8A:
undetectable		 4yo9B-4ad8A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4ad8 DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		4 / 5 SER A 150
ALA A 151
HIS A 146
LEU A 450
 None
 1.37A 5dzkb-4ad8A:
undetectable
5dzkp-4ad8A:
undetectable		 5dzkb-4ad8A:
18.58
5dzkp-4ad8A:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4ad8 DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		4 / 5 SER A 150
ALA A 151
HIS A 146
LEU A 450
 None
 1.39A 5dzkc-4ad8A:
undetectable
5dzkq-4ad8A:
undetectable		 5dzkc-4ad8A:
18.58
5dzkq-4ad8A:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4ad8 DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		4 / 8 SER A 150
ALA A 151
LEU A 450
LEU A 441
 None
 1.10A 5dzkd-4ad8A:
undetectable
5dzkr-4ad8A:
undetectable		 5dzkd-4ad8A:
18.58
5dzkr-4ad8A:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4ad8 DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		4 / 5 SER A 150
ALA A 151
HIS A 146
LEU A 450
 None
 1.40A 5dzkf-4ad8A:
undetectable
5dzkt-4ad8A:
undetectable		 5dzkf-4ad8A:
18.58
5dzkt-4ad8A:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD2_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 4ad8 DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		4 / 4 GLY A  55
CYH A  57
ARG A  33
GLY A  53
 None
 1.31A 5inzA-4ad8A:
undetectable
5inzC-4ad8A:
undetectable
5inzD-4ad8A:
undetectable		 5inzA-4ad8A:
2.96
5inzC-4ad8A:
2.96
5inzD-4ad8A:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4ad8 DNA REPAIR PROTEIN
RECN
(Deinococcus
radiodurans) 		4 / 6 GLY A  75
LEU A  86
ARG A 113
VAL A  96
 None
 0.96A 5x80A-4ad8A:
undetectable
5x80B-4ad8A:
1.4		 5x80A-4ad8A:
16.99
5x80B-4ad8A:
16.99