SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ad9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A  84
GLY A  85
GLY A  87
ASP A  81
HIS A  82
 None
None
None
ZN  A1000 (-2.8A)
ZN  A1000 (-3.4A)
 1.22A 1wg8A-4ad9A:
undetectable		 1wg8A-4ad9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A  84
GLY A  85
GLY A  87
ASP A  81
HIS A  82
 None
None
None
ZN  A1000 (-2.8A)
ZN  A1000 (-3.4A)
 1.20A 1wg8B-4ad9A:
undetectable		 1wg8B-4ad9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A  28
GLY A 200
GLN A  29
HIS A 204
ILE A 195
 None
 1.47A 1z95A-4ad9A:
undetectable		 1z95A-4ad9A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 THR A 172
THR A 142
LEU A 167
GLY A 163
THR A  76
 None
 1.16A 2a1nA-4ad9A:
undetectable		 2a1nA-4ad9A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 TYR A 180
THR A 172
THR A 142
GLY A 163
THR A  76
 None
 1.14A 2a1nA-4ad9A:
undetectable		 2a1nA-4ad9A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 ASP A  81
HIS A  82
HIS A 145
ASP A 164
HIS A 199
 ZN  A1000 (-2.8A)
ZN  A1000 (-3.4A)
ZN  A1001 (-3.3A)
ZN  A1000 ( 2.3A)
ZN  A1000 (-3.3A)
 0.29A 2q0jB-4ad9A:
21.1		 2q0jB-4ad9A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 6 LEU A 124
GLU A  72
LEU A 104
THR A  76
 None
 0.99A 2roxB-4ad9A:
undetectable		 2roxB-4ad9A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 ILE A  93
ILE A  73
THR A  33
VAL A  18
LEU A  35
 None
 1.20A 3a51A-4ad9A:
undetectable		 3a51A-4ad9A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A  93
ILE A  73
THR A  33
VAL A  18
LEU A  35
 None
 1.21A 3a51D-4ad9A:
undetectable		 3a51D-4ad9A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A  93
ILE A  73
THR A  33
VAL A  18
LEU A  35
 None
 1.21A 3a51E-4ad9A:
undetectable		 3a51E-4ad9A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 8 HIS A  77
THR A  31
HIS A 145
LEU A   5
 ZN  A1001 (-3.4A)
None
ZN  A1001 (-3.3A)
None
 1.17A 3ablA-4ad9A:
undetectable
3ablC-4ad9A:
undetectable
3ablP-4ad9A:
undetectable		 3ablA-4ad9A:
19.45
3ablC-4ad9A:
20.13
3ablP-4ad9A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 8 HIS A  77
THR A  31
HIS A 149
LEU A  59
 ZN  A1001 (-3.4A)
None
None
None
 1.17A 3ablA-4ad9A:
undetectable
3ablC-4ad9A:
undetectable
3ablP-4ad9A:
undetectable		 3ablA-4ad9A:
19.45
3ablC-4ad9A:
20.13
3ablP-4ad9A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		3 / 3 HIS A 259
GLU A 255
HIS A 254
 None
 0.89A 3ba0A-4ad9A:
undetectable		 3ba0A-4ad9A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 TYR A  34
ILE A 194
GLY A 198
LEU A   5
LEU A  11
 None
 1.17A 3em0B-4ad9A:
undetectable		 3em0B-4ad9A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2U_A_ELVA397_1
(INTEGRASE)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 5 ASP A 147
ASP A 148
TYR A 121
PRO A 105
 None
 1.20A 3l2uA-4ad9A:
undetectable		 3l2uA-4ad9A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2W_A_ELVA397_1
(INTEGRASE)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 5 ASP A 147
ASP A 148
TYR A 121
PRO A 105
 None
 1.17A 3l2wA-4ad9A:
0.9		 3l2wA-4ad9A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 10 THR A 172
THR A 142
LEU A 167
GLY A 163
THR A  76
 None
 1.11A 3lxiA-4ad9A:
undetectable		 3lxiA-4ad9A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 10 TYR A 180
THR A 172
THR A 142
GLY A 163
THR A  76
 None
 1.07A 3lxiA-4ad9A:
undetectable		 3lxiA-4ad9A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 THR A 172
THR A 142
LEU A 167
GLY A 163
THR A  76
 None
 1.11A 3lxiB-4ad9A:
undetectable		 3lxiB-4ad9A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 TYR A 180
THR A 172
THR A 142
GLY A 163
THR A  76
 None
 1.06A 3lxiB-4ad9A:
undetectable		 3lxiB-4ad9A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASP A  81
GLY A  87
ILE A  70
THR A  47
ILE A  73
 ZN  A1000 (-2.8A)
None
None
None
None
 0.74A 3pwwA-4ad9A:
undetectable		 3pwwA-4ad9A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 7 ASP A 147
ASP A 148
TYR A 121
PRO A 105
 None
 1.12A 3s3oA-4ad9A:
undetectable		 3s3oA-4ad9A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 8 LEU A   5
HIS A  77
THR A  31
HIS A 145
 None
ZN  A1001 (-3.4A)
None
ZN  A1001 (-3.3A)
 1.22A 3wg7C-4ad9A:
undetectable
3wg7N-4ad9A:
undetectable
3wg7P-4ad9A:
undetectable		 3wg7C-4ad9A:
20.13
3wg7N-4ad9A:
19.45
3wg7P-4ad9A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 10 HIS A  77
HIS A  79
ASP A  81
HIS A 145
HIS A 199
 ZN  A1001 (-3.4A)
ZN  A1001 (-3.3A)
ZN  A1000 (-2.8A)
ZN  A1001 (-3.3A)
ZN  A1000 (-3.3A)
 0.76A 4c1dB-4ad9A:
20.1		 4c1dB-4ad9A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 HIS A  77
HIS A  79
ASP A  81
HIS A 145
HIS A 199
 ZN  A1001 (-3.4A)
ZN  A1001 (-3.3A)
ZN  A1000 (-2.8A)
ZN  A1001 (-3.3A)
ZN  A1000 (-3.3A)
 0.81A 4c1fA-4ad9A:
19.9
4c1fB-4ad9A:
19.9		 4c1fA-4ad9A:
24.07
4c1fB-4ad9A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 HIS A  77
HIS A  79
ASP A  81
HIS A 145
HIS A 199
 ZN  A1001 (-3.4A)
ZN  A1001 (-3.3A)
ZN  A1000 (-2.8A)
ZN  A1001 (-3.3A)
ZN  A1000 (-3.3A)
 0.76A 4c1hA-4ad9A:
21.5		 4c1hA-4ad9A:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 GLY A  84
ASP A  81
GLY A  48
VAL A  75
HIS A 199
 None
ZN  A1000 (-2.8A)
None
None
ZN  A1000 (-3.3A)
 1.13A 4c5lA-4ad9A:
undetectable		 4c5lA-4ad9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 GLY A  84
ASP A  81
GLY A  48
VAL A  75
HIS A 199
 None
ZN  A1000 (-2.8A)
None
None
ZN  A1000 (-3.3A)
 1.20A 4c5lB-4ad9A:
undetectable		 4c5lB-4ad9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 10 GLY A  84
ASP A  81
GLY A  48
VAL A  75
HIS A 199
 None
ZN  A1000 (-2.8A)
None
None
ZN  A1000 (-3.3A)
 1.13A 4c5lC-4ad9A:
undetectable		 4c5lC-4ad9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 10 GLY A  84
ASP A  81
GLY A  48
VAL A  75
HIS A 199
 None
ZN  A1000 (-2.8A)
None
None
ZN  A1000 (-3.3A)
 1.14A 4c5lD-4ad9A:
undetectable		 4c5lD-4ad9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 7 GLY A  84
ASP A  81
GLY A  48
HIS A 199
 None
ZN  A1000 (-2.8A)
None
ZN  A1000 (-3.3A)
 0.92A 4c5nA-4ad9A:
undetectable		 4c5nA-4ad9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 10 GLY A  84
ASP A  81
GLY A  48
HIS A  77
HIS A 199
 None
ZN  A1000 (-2.8A)
None
ZN  A1001 (-3.4A)
ZN  A1000 (-3.3A)
 0.97A 4c5nB-4ad9A:
undetectable		 4c5nB-4ad9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 10 GLY A  84
ASP A  81
GLY A  48
HIS A  79
VAL A  75
 None
ZN  A1000 (-2.8A)
None
ZN  A1001 (-3.3A)
None
 1.25A 4c5nB-4ad9A:
undetectable		 4c5nB-4ad9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 10 GLY A  84
ASP A  81
GLY A  48
VAL A  75
HIS A 199
 None
ZN  A1000 (-2.8A)
None
None
ZN  A1000 (-3.3A)
 1.21A 4c5nB-4ad9A:
undetectable		 4c5nB-4ad9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 8 GLY A  84
ASP A  81
GLY A  48
VAL A  75
HIS A 199
 None
ZN  A1000 (-2.8A)
None
None
ZN  A1000 (-3.3A)
 1.19A 4c5nC-4ad9A:
undetectable		 4c5nC-4ad9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 10 GLY A  84
ASP A  81
GLY A  48
VAL A  75
HIS A 199
 None
ZN  A1000 (-2.8A)
None
None
ZN  A1000 (-3.3A)
 1.15A 4c5nD-4ad9A:
undetectable		 4c5nD-4ad9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 TYR A 180
THR A 172
THR A 142
GLY A 163
THR A  76
 None
 1.07A 4c9kA-4ad9A:
undetectable		 4c9kA-4ad9A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 8 LEU A  59
ILE A  73
VAL A  75
GLY A  48
 None
 0.95A 4eq4B-4ad9A:
undetectable		 4eq4B-4ad9A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 8 LEU A  59
ILE A  73
VAL A  75
GLY A  85
 None
 0.89A 4eq4B-4ad9A:
undetectable		 4eq4B-4ad9A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 8 HIS A  79
ASP A  81
HIS A 145
HIS A 199
 ZN  A1001 (-3.3A)
ZN  A1000 (-2.8A)
ZN  A1001 (-3.3A)
ZN  A1000 (-3.3A)
 0.77A 4exsB-4ad9A:
6.6		 4exsB-4ad9A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 6 LYS A 102
LEU A 124
LEU A 104
THR A  76
 None
 1.01A 4ikiB-4ad9A:
undetectable		 4ikiB-4ad9A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 5 ILE A  86
ILE A 113
TYR A 121
GLU A 112
 None
 1.23A 4zzcE-4ad9A:
undetectable		 4zzcE-4ad9A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 8 HIS A  79
ASP A  81
HIS A 145
HIS A 199
 ZN  A1001 (-3.3A)
ZN  A1000 (-2.8A)
ZN  A1001 (-3.3A)
ZN  A1000 (-3.3A)
 0.78A 5a5zA-4ad9A:
18.8		 5a5zA-4ad9A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		7 / 11 HIS A  77
HIS A  79
ASP A  81
HIS A  82
HIS A 145
VAL A 173
HIS A 199
 ZN  A1001 (-3.4A)
ZN  A1001 (-3.3A)
ZN  A1000 (-2.8A)
ZN  A1000 (-3.4A)
ZN  A1001 (-3.3A)
None
ZN  A1000 (-3.3A)
 0.61A 5ayaA-4ad9A:
17.8		 5ayaA-4ad9A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		7 / 11 HIS A  77
HIS A  79
ASP A  81
HIS A  82
THR A 172
VAL A 173
HIS A 199
 ZN  A1001 (-3.4A)
ZN  A1001 (-3.3A)
ZN  A1000 (-2.8A)
ZN  A1000 (-3.4A)
None
None
ZN  A1000 (-3.3A)
 0.98A 5ayaA-4ad9A:
17.8		 5ayaA-4ad9A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 8 LEU A   5
HIS A  77
THR A  31
HIS A 145
 None
ZN  A1001 (-3.4A)
None
ZN  A1001 (-3.3A)
 1.18A 5iy5C-4ad9A:
undetectable
5iy5N-4ad9A:
undetectable
5iy5P-4ad9A:
undetectable		 5iy5C-4ad9A:
19.44
5iy5N-4ad9A:
19.45
5iy5P-4ad9A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASP A  81
ILE A  45
ASP A  46
ASP A 164
LEU A 167
 ZN  A1000 (-2.8A)
None
None
ZN  A1000 ( 2.3A)
None
 1.47A 5nn8A-4ad9A:
undetectable		 5nn8A-4ad9A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 10 HIS A  77
HIS A  79
HIS A  82
HIS A 145
ASP A 164
 ZN  A1001 (-3.4A)
ZN  A1001 (-3.3A)
ZN  A1000 (-3.4A)
ZN  A1001 (-3.3A)
ZN  A1000 ( 2.3A)
 0.30A 5nzwA-4ad9A:
3.9		 5nzwA-4ad9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1471_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 ASP A  46
GLY A 198
HIS A  79
THR A 146
HIS A 149
 None
None
ZN  A1001 (-3.3A)
None
None
 1.34A 5x7pB-4ad9A:
undetectable		 5x7pB-4ad9A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 8 LEU A   5
HIS A  77
THR A  31
HIS A 145
 None
ZN  A1001 (-3.4A)
None
ZN  A1001 (-3.3A)
 1.20A 5xdqC-4ad9A:
undetectable
5xdqN-4ad9A:
undetectable
5xdqP-4ad9A:
undetectable		 5xdqC-4ad9A:
20.13
5xdqN-4ad9A:
19.45
5xdqP-4ad9A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 8 LEU A   5
HIS A  77
THR A  31
HIS A 145
 None
ZN  A1001 (-3.4A)
None
ZN  A1001 (-3.3A)
 1.18A 5xdxC-4ad9A:
undetectable
5xdxN-4ad9A:
undetectable
5xdxP-4ad9A:
undetectable		 5xdxC-4ad9A:
19.75
5xdxN-4ad9A:
19.45
5xdxP-4ad9A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 11 GLY A 134
ARG A  14
VAL A  36
PHE A 161
GLY A  37
 None
 1.30A 5yjsA-4ad9A:
undetectable		 5yjsA-4ad9A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 7 LEU A   5
HIS A  77
THR A  31
HIS A 145
 None
ZN  A1001 (-3.4A)
None
ZN  A1001 (-3.3A)
 1.22A 5z84C-4ad9A:
undetectable
5z84N-4ad9A:
undetectable
5z84P-4ad9A:
undetectable		 5z84C-4ad9A:
20.13
5z84N-4ad9A:
19.45
5z84P-4ad9A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 8 HIS A  79
ASP A  81
HIS A 145
HIS A 199
 ZN  A1001 (-3.3A)
ZN  A1000 (-2.8A)
ZN  A1001 (-3.3A)
ZN  A1000 (-3.3A)
 0.83A 5zj8A-4ad9A:
19.0		 5zj8A-4ad9A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 101
VAL A 202
LEU A   5
GLY A  85
LEU A  44
 None
 0.96A 6a7pA-4ad9A:
undetectable		 6a7pA-4ad9A:
18.90