SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ade'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		4 / 8 GLY A 257
GLY A  54
LEU A  33
ASP A  43
 None
 0.85A 1aegA-4adeA:
undetectable		 1aegA-4adeA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		4 / 8 GLY A 230
ARG A 231
LEU A 379
VAL A 295
 None
 1.03A 1gsfA-4adeA:
undetectable		 1gsfA-4adeA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		4 / 8 GLY A 230
ARG A 231
LEU A 379
VAL A 295
 None
 1.03A 1gsfB-4adeA:
undetectable		 1gsfB-4adeA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		4 / 8 GLY A 230
ARG A 231
LEU A 379
VAL A 295
 None
 1.03A 1gsfC-4adeA:
undetectable		 1gsfC-4adeA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		4 / 8 GLY A 230
ARG A 231
LEU A 379
VAL A 295
 None
 1.03A 1gsfD-4adeA:
undetectable		 1gsfD-4adeA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		4 / 8 ALA A  96
LEU A 248
ALA A 262
THR A 250
 None
 0.80A 1ie4B-4adeA:
undetectable
1ie4D-4adeA:
undetectable		 1ie4B-4adeA:
17.37
1ie4D-4adeA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		5 / 6 LYS A  88
LYS A  89
ASP A  92
ALA A  93
LEU A 235
 None
 1.10A 1iwhA-4adeA:
undetectable		 1iwhA-4adeA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		3 / 3 ALA A 112
THR A 249
PHE A 144
 None
 0.67A 2c6nB-4adeA:
undetectable		 2c6nB-4adeA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		4 / 6 ARG A 333
ILE A 367
GLU A 195
TYR A 154
 None
 1.33A 2ya7C-4adeA:
undetectable		 2ya7C-4adeA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		3 / 3 SER A  69
GLN A  67
PHE A  71
 None
 0.85A 3g4lC-4adeA:
undetectable		 3g4lC-4adeA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		5 / 12 GLY A 256
GLY A 257
LEU A 379
ARG A 231
MET A 304
 None
 1.21A 3h52B-4adeA:
undetectable		 3h52B-4adeA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		5 / 12 PHE A 144
ALA A 148
SER A 155
ALA A 116
ILE A 188
 None
 1.08A 3lbdA-4adeA:
undetectable		 3lbdA-4adeA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		4 / 5 SER A  31
SER A 382
VAL A 381
GLY A  54
 None
 1.03A 3rxhA-4adeA:
undetectable		 3rxhA-4adeA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		3 / 3 HIS A  73
SER A 289
ASN A 103
 None
 0.78A 3s8pB-4adeA:
undetectable		 3s8pB-4adeA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		4 / 6 HIS A 127
GLY A 125
ALA A 120
TYR A 124
 None
 0.98A 4ae1A-4adeA:
undetectable		 4ae1A-4adeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		5 / 9 LEU A  60
GLY A 257
VAL A 291
VAL A 295
LEU A 296
 None
 1.09A 4qd3A-4adeA:
undetectable		 4qd3A-4adeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		3 / 3 MET A 239
GLU A 234
LEU A 235
 None
 0.80A 4v2oB-4adeA:
undetectable		 4v2oB-4adeA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		3 / 3 LYS A 114
ARG A 117
HIS A 121
 None
 1.25A 4zbrA-4adeA:
undetectable		 4zbrA-4adeA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		6 / 12 GLY A 255
GLY A 257
GLY A  54
LEU A  53
ALA A 288
LEU A 254
 None
 1.42A 5c0oG-4adeA:
2.2		 5c0oG-4adeA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		3 / 3 HIS A  73
SER A 289
ASN A 103
 None
 0.84A 5cprB-4adeA:
undetectable		 5cprB-4adeA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		5 / 12 GLY A 279
HIS A 278
VAL A 225
GLY A 283
THR A 281
 None
 1.04A 5hg0B-4adeA:
undetectable		 5hg0B-4adeA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		4 / 5 GLU A 234
GLU A 224
THR A 250
LEU A 296
 None
 1.15A 5hm8G-4adeA:
undetectable		 5hm8G-4adeA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		4 / 6 ILE A 221
ALA A 116
LEU A 113
ILE A 131
 None
 0.87A 5mvmB-4adeA:
undetectable
5mvmC-4adeA:
undetectable		 5mvmB-4adeA:
15.62
5mvmC-4adeA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		6 / 12 GLY A 334
PHE A 315
VAL A 316
ILE A 367
ALA A 368
VAL A 373
 None
 1.27A 5n0sA-4adeA:
undetectable		 5n0sA-4adeA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		5 / 12 GLY A 334
PHE A 315
VAL A 316
ILE A 367
ALA A 368
 None
 1.00A 5n0tA-4adeA:
undetectable		 5n0tA-4adeA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		5 / 12 GLY A 334
PHE A 315
VAL A 316
ILE A 367
ALA A 368
 None
 1.02A 5n0tB-4adeA:
undetectable		 5n0tB-4adeA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		6 / 12 GLY A 334
PHE A 315
VAL A 316
ILE A 367
ALA A 368
VAL A 373
 None
 1.31A 5n0wB-4adeA:
undetectable		 5n0wB-4adeA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		5 / 12 GLY A 334
PHE A 315
VAL A 316
ILE A 367
ALA A 368
 None
 1.02A 5n0xA-4adeA:
undetectable		 5n0xA-4adeA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		6 / 12 GLY A 334
PHE A 315
VAL A 316
ILE A 367
ALA A 368
VAL A 373
 None
 1.33A 5n4iA-4adeA:
undetectable		 5n4iA-4adeA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		3 / 3 THR A 281
HIS A  73
ASN A 285
 None
 0.77A 5n4tA-4adeA:
undetectable		 5n4tA-4adeA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		5 / 12 GLY A 256
GLY A 257
LEU A 379
ARG A 231
MET A 304
 None
 1.11A 5uc1A-4adeA:
undetectable		 5uc1A-4adeA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		5 / 12 GLY A 256
GLY A 257
LEU A 379
ARG A 231
MET A 304
 None
 1.15A 5uc1B-4adeA:
undetectable		 5uc1B-4adeA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		4 / 7 GLN A 226
GLY A 233
GLY A 336
VAL A 308
 None
 0.86A 6ekzA-4adeA:
undetectable		 6ekzA-4adeA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 4ade SUCCINYLORNITHINE
TRANSAMINASE
(Escherichia
coli) 		3 / 3 HIS A  73
ASN A 285
LEU A 287
 None
 0.73A 6f7lB-4adeA:
undetectable		 6f7lB-4adeA:
24.28