SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ae5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 4ae5 SIGNAL TRANSDUCTION
PROTEIN TRAP
(Staphylococcus
aureus) 		3 / 3 GLU A  39
HIS A  24
ASP A  42
 None
 0.76A 1i9gA-4ae5A:
undetectable		 1i9gA-4ae5A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ae5 SIGNAL TRANSDUCTION
PROTEIN TRAP
(Staphylococcus
aureus) 		3 / 3 VAL A  46
LYS A  48
HIS A  15
 None
 0.93A 3elzA-4ae5A:
1.2		 3elzA-4ae5A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 4ae5 SIGNAL TRANSDUCTION
PROTEIN TRAP
(Staphylococcus
aureus) 		4 / 7 PHE A  62
PHE A  38
SER A 102
TYR A 103
 None
 1.38A 3hggA-4ae5A:
undetectable		 3hggA-4ae5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 4ae5 SIGNAL TRANSDUCTION
PROTEIN TRAP
(Staphylococcus
aureus) 		4 / 6 PHE A 118
PHE A 120
PHE A  94
ALA A 134
 None
 0.87A 3t3sB-4ae5A:
undetectable		 3t3sB-4ae5A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 4ae5 SIGNAL TRANSDUCTION
PROTEIN TRAP
(Staphylococcus
aureus) 		4 / 8 PHE A 118
PHE A 120
PHE A  94
ALA A 134
 None
 0.87A 3t3sD-4ae5A:
undetectable		 3t3sD-4ae5A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4ae5 SIGNAL TRANSDUCTION
PROTEIN TRAP
(Staphylococcus
aureus) 		5 / 12 PRO A 108
LEU A  83
LEU A  87
ILE A  56
PHE A 139
 None
 1.05A 4a7aB-4ae5A:
undetectable		 4a7aB-4ae5A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 4ae5 SIGNAL TRANSDUCTION
PROTEIN TRAP
(Staphylococcus
aureus) 		4 / 7 PHE A 129
ASN A 136
ILE A 116
PHE A 118
 None
 0.86A 4ejjD-4ae5A:
undetectable		 4ejjD-4ae5A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4ae5 SIGNAL TRANSDUCTION
PROTEIN TRAP
(Staphylococcus
aureus) 		3 / 3 GLU A  39
HIS A  24
ASP A  42
 None
 0.64A 5c0oG-4ae5A:
undetectable		 5c0oG-4ae5A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 4ae5 SIGNAL TRANSDUCTION
PROTEIN TRAP
(Staphylococcus
aureus) 		4 / 6 ILE A  73
TYR A 157
PHE A 158
PHE A 135
 None
 1.30A 5g08A-4ae5A:
undetectable		 5g08A-4ae5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 4ae5 SIGNAL TRANSDUCTION
PROTEIN TRAP
(Staphylococcus
aureus) 		3 / 3 TYR A   8
PRO A  50
LEU A  47
 FMT  A1000 (-4.5A)
None
None
 0.71A 6beoA-4ae5A:
undetectable		 6beoA-4ae5A:
4.58