SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ae7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ae7 THIOESTERASE
SUPERFAMILY MEMBER 5
(Homo
sapiens) 		3 / 3 GLY A 159
PRO A 153
LEU A 193
 None
 0.45A 3hcpB-4ae7A:
undetectable		 3hcpB-4ae7A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4ae7 THIOESTERASE
SUPERFAMILY MEMBER 5
(Homo
sapiens) 		4 / 5 GLU A 151
LEU A 150
GLN A 125
GLY A 126
 None
 1.16A 3pp1A-4ae7A:
undetectable		 3pp1A-4ae7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ae7 THIOESTERASE
SUPERFAMILY MEMBER 5
(Homo
sapiens) 		4 / 5 MET A 166
LEU A 186
ARG A 189
SER A 140
 None
 1.48A 4kmmB-4ae7A:
undetectable		 4kmmB-4ae7A:
20.16