SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4aec'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 10 SER A 356
ALA A 359
GLY A 333
ALA A 380
ILE A 334
 None
None
PLP  A 500 (-3.6A)
None
PLP  A 500 (-4.8A)
 1.23A 1gtnH-4aecA:
undetectable
1gtnI-4aecA:
undetectable		 1gtnH-4aecA:
11.97
1gtnI-4aecA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 10 GLY A 270
ILE A 157
GLY A 292
ILE A 294
PRO A 404
 None
None
PLP  A 500 (-3.6A)
None
PLP  A 500 (-4.2A)
 1.06A 1sh9B-4aecA:
undetectable		 1sh9B-4aecA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		3 / 3 MET A 209
ASN A 185
GLN A 255
 None
PLP  A 500 (-3.8A)
None
 0.82A 1xoqB-4aecA:
undetectable		 1xoqB-4aecA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 ILE A 188
GLY A 189
GLY A 158
GLY A 184
ALA A 191
 None
 0.98A 2fk8A-4aecA:
undetectable		 2fk8A-4aecA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 7 GLY A 184
GLN A 255
PHE A 256
PHE A 338
 None
 1.19A 2qx4A-4aecA:
undetectable
2qx4B-4aecA:
undetectable		 2qx4A-4aecA:
21.48
2qx4B-4aecA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 8 ALA A 286
GLY A 298
ILE A 347
PRO A 262
 None
 0.74A 3el9A-4aecA:
undetectable		 3el9A-4aecA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 10 GLY A 270
ILE A 157
GLY A 292
ILE A 294
PRO A 404
 None
None
PLP  A 500 (-3.6A)
None
PLP  A 500 (-4.2A)
 1.04A 3el9B-4aecA:
undetectable		 3el9B-4aecA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 7 VAL A 310
ILE A 273
THR A 268
GLY A 298
 None
 0.95A 3gssB-4aecA:
undetectable		 3gssB-4aecA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 LEU A 253
GLY A 189
GLY A 187
LEU A 216
ALA A 194
 None
 1.22A 3i5uA-4aecA:
2.2		 3i5uA-4aecA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 GLY A 333
GLY A 375
PHE A 403
ALA A 381
ALA A 382
 PLP  A 500 (-3.6A)
None
None
None
None
 1.08A 3keeD-4aecA:
undetectable		 3keeD-4aecA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_1
(PROTEASE)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 GLY A 270
ILE A 157
GLY A 292
ILE A 294
PRO A 404
 None
None
PLP  A 500 (-3.6A)
None
PLP  A 500 (-4.2A)
 0.95A 3ndtC-4aecA:
undetectable		 3ndtC-4aecA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 GLY A 270
ILE A 157
GLY A 292
ILE A 294
PRO A 404
 None
None
PLP  A 500 (-3.6A)
None
PLP  A 500 (-4.2A)
 0.94A 3nduC-4aecA:
undetectable		 3nduC-4aecA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 9 GLY A 221
ILE A 202
GLY A 187
ILE A 188
LEU A 224
 None
 0.97A 3ogpB-4aecA:
undetectable		 3ogpB-4aecA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 5 GLY A 335
GLU A 314
GLY A 337
PRO A 315
 None
 1.06A 3onnA-4aecA:
2.9		 3onnA-4aecA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 GLY A 270
ILE A 157
GLY A 292
ILE A 294
PRO A 404
 None
None
PLP  A 500 (-3.6A)
None
PLP  A 500 (-4.2A)
 0.94A 3oxcB-4aecA:
undetectable		 3oxcB-4aecA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 GLY A 333
GLY A 375
PHE A 403
ALA A 381
ALA A 382
 PLP  A 500 (-3.6A)
None
None
None
None
 1.07A 3sueA-4aecA:
undetectable		 3sueA-4aecA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 GLY A 270
ILE A 157
GLY A 292
ILE A 294
PRO A 404
 None
None
PLP  A 500 (-3.6A)
None
PLP  A 500 (-4.2A)
 0.97A 3tkgA-4aecA:
undetectable		 3tkgA-4aecA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 6 PHE A 403
ALA A 142
ALA A 385
LEU A 129
 None
 0.79A 4dtzA-4aecA:
undetectable		 4dtzA-4aecA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 6 VAL A 401
ALA A 142
LEU A 372
THR A 362
LEU A 366
 None
 1.31A 4o0uA-4aecA:
undetectable		 4o0uA-4aecA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 4 GLU A 272
GLY A 270
HIS A 265
ARG A 156
 None
 1.18A 4r82A-4aecA:
undetectable
4r82B-4aecA:
undetectable		 4r82A-4aecA:
19.19
4r82B-4aecA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 10 TYR A 199
ALA A 165
LEU A 178
LEU A 190
TYR A 251
 None
 1.23A 4xj7A-4aecA:
undetectable
4xj7B-4aecA:
undetectable		 4xj7A-4aecA:
20.00
4xj7B-4aecA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		6 / 12 VAL A 285
LEU A 366
GLU A 350
ILE A 386
VAL A 127
LEU A 144
 None
 1.49A 4y0sA-4aecA:
undetectable		 4y0sA-4aecA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 GLY A 291
GLY A 337
GLY A 335
GLY A 289
GLU A 314
 PLP  A 500 (-3.5A)
None
None
PLP  A 500 (-3.7A)
None
 0.94A 5njvC-4aecA:
undetectable		 5njvC-4aecA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 PRO A 125
THR A 124
GLU A 148
GLU A 272
THR A 293
 None
None
None
None
PLP  A 500 (-3.6A)
 1.18A 5xipC-4aecA:
undetectable		 5xipC-4aecA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 PRO A 125
THR A 124
GLU A 148
GLU A 272
THR A 293
 None
None
None
None
PLP  A 500 (-3.6A)
 1.18A 5xipD-4aecA:
undetectable		 5xipD-4aecA:
20.70