SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4aej'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4aej COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		5 / 11 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.46A 1lwcA-4aejA:
undetectable		 1lwcA-4aejA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4aej COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		5 / 12 ALA A  84
VAL A 239
PHE A 235
ILE A 223
ASP A 222
 None
 1.30A 2v95A-4aejA:
undetectable		 2v95A-4aejA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4aej COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		4 / 5 LEU A  87
ILE A 223
TRP A  94
TYR A 119
 None
 1.26A 2zlcA-4aejA:
undetectable		 2zlcA-4aejA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 4aej COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		4 / 7 VAL A 207
ILE A 220
GLY A 173
ARG A 217
 GOL  A1248 ( 4.4A)
None
None
None
 0.92A 3bjwH-4aejA:
undetectable		 3bjwH-4aejA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 4aej COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		3 / 3 MET A  75
VAL A  71
GLU A  79
 None
None
GOL  A1246 (-3.1A)
 0.83A 3c6gA-4aejA:
undetectable		 3c6gA-4aejA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4aej COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		4 / 8 VAL A 242
VAL A 221
GLN A 116
ILE A  69
 None
 0.90A 3hjoA-4aejA:
undetectable		 3hjoA-4aejA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEE_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 4aej COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		5 / 12 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.42A 3meeA-4aejA:
undetectable		 3meeA-4aejA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEG_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 4aej COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		5 / 12 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.46A 3megA-4aejA:
undetectable		 3megA-4aejA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4aej COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		4 / 8 ALA A  84
GLN A 145
ILE A 147
ILE A 223
 None
 0.90A 4kttD-4aejA:
undetectable		 4kttD-4aejA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 4aej COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		3 / 3 ALA A  68
TRP A  57
VAL A  58
 None
 0.34A 4w9nC-4aejA:
undetectable		 4w9nC-4aejA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4aej COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		5 / 12 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.48A 5cymA-4aejA:
undetectable		 5cymA-4aejA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4aej COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		5 / 12 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.43A 5cyqA-4aejA:
undetectable		 5cyqA-4aejA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4aej COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		5 / 11 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.42A 5hbmA-4aejA:
undetectable		 5hbmA-4aejA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4aej COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		5 / 12 ILE A 223
ALA A 224
PHE A 117
GLY A 108
VAL A 239
 None
 1.06A 5i71A-4aejA:
undetectable		 5i71A-4aejA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4aej COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		5 / 12 ILE A 223
ALA A 224
PHE A 117
GLY A 108
VAL A 239
 None
 1.09A 5i75A-4aejA:
undetectable		 5i75A-4aejA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 4aej COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		4 / 6 PHE A 179
GLY A 173
GLN A 145
TYR A 119
 None
 1.20A 6ag0A-4aejA:
undetectable		 6ag0A-4aejA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 4aej COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		4 / 6 PHE A 179
GLY A 173
GLN A 145
TYR A 119
 None
 1.20A 6ag0C-4aejA:
undetectable		 6ag0C-4aejA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 4aej COLLAGEN
ALPHA-1(III) CHAIN
(Homo
sapiens) 		5 / 12 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.44A 6eliA-4aejA:
undetectable		 6eliA-4aejA:
17.36