SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4aez'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 4aez MITOTIC SPINDLE
CHECKPOINT COMPONENT
MAD3
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP C 170
TYR C 173
GLU C 161
 None
 0.86A 1vm1A-4aezC:
undetectable		 1vm1A-4aezC:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 4aez MITOTIC SPINDLE
CHECKPOINT COMPONENT
MAD3
(Schizosaccharomy
ces
pombe) 		4 / 8 TYR C 191
PHE C 187
ARG C 197
ALA C 157
 None
 1.08A 1x8vA-4aezC:
undetectable		 1x8vA-4aezC:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 4aez MITOTIC SPINDLE
CHECKPOINT COMPONENT
MAD3
(Schizosaccharomy
ces
pombe) 		4 / 8 TYR C 191
PHE C 187
ARG C 197
ALA C 169
 None
 1.13A 1x8vA-4aezC:
undetectable		 1x8vA-4aezC:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 4aez MITOTIC SPINDLE
CHECKPOINT COMPONENT
MAD3
(Schizosaccharomy
ces
pombe) 		4 / 4 ILE C 122
ASP C  84
LEU C  96
ARG C 121
 None
 1.45A 2a7qA-4aezC:
undetectable		 2a7qA-4aezC:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 4aez MITOTIC SPINDLE
CHECKPOINT COMPONENT
MAD3
(Schizosaccharomy
ces
pombe) 		3 / 3 PHE C 139
VAL C 108
TRP C 123
 None
 0.89A 2cc8A-4aezC:
undetectable		 2cc8A-4aezC:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 4aez MITOTIC SPINDLE
CHECKPOINT COMPONENT
MAD3
(Schizosaccharomy
ces
pombe) 		3 / 3 PHE C 139
VAL C 108
TRP C 123
 None
 0.89A 2ccbA-4aezC:
undetectable		 2ccbA-4aezC:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 4aez WD REPEAT-CONTAINING
PROTEIN SLP1
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP A 208
SER A 209
SER A 211
GLN A 253
 None
 1.08A 2cmlB-4aezA:
6.4		 2cmlB-4aezA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4aez MITOTIC SPINDLE
CHECKPOINT COMPONENT
MAD3
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP C  84
ASN C  85
THR C  91
 None
 0.58A 2pymB-4aezC:
undetectable		 2pymB-4aezC:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 4aez MITOTIC SPINDLE
CHECKPOINT COMPONENT
MAD3
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP C  84
ASN C  85
THR C  91
 None
 0.73A 2q63B-4aezC:
undetectable		 2q63B-4aezC:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 4aez MITOTIC SPINDLE
CHECKPOINT COMPONENT
MAD3
(Schizosaccharomy
ces
pombe) 		3 / 3 PHE C 139
VAL C 108
TRP C 123
 None
 0.88A 2vx9A-4aezC:
undetectable		 2vx9A-4aezC:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 4aez MITOTIC SPINDLE
CHECKPOINT COMPONENT
MAD3
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU C 136
LEU C 120
VAL C 127
PHE C 137
THR C 104
 None
 1.13A 2w9gA-4aezC:
undetectable		 2w9gA-4aezC:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 4aez MITOTIC SPINDLE
CHECKPOINT COMPONENT
MAD3
WD REPEAT-CONTAINING
PROTEIN SLP1
(Schizosaccharomy
ces
pombe) 		4 / 6 ARG A 281
ASP A 180
ILE A 178
GLU C  47
 None
 1.45A 2ya7C-4aezA:
2.8		 2ya7C-4aezA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 4aez WD REPEAT-CONTAINING
PROTEIN SLP1
(Schizosaccharomy
ces
pombe) 		5 / 10 ALA A 389
ASP A 388
GLY A 367
ALA A 363
ILE A 373
 None
 0.94A 3ekpB-4aezA:
undetectable		 3ekpB-4aezA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 4aez WD REPEAT-CONTAINING
PROTEIN SLP1
(Schizosaccharomy
ces
pombe) 		5 / 9 ALA A 389
ASP A 388
GLY A 367
ALA A 363
ILE A 373
 None
 1.07A 3ektB-4aezA:
undetectable		 3ektB-4aezA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4aez WD REPEAT-CONTAINING
PROTEIN SLP1
(Schizosaccharomy
ces
pombe) 		5 / 12 TYR A 181
GLY A 322
GLY A 323
ALA A 351
VAL A 352
 None
 0.97A 3jb2A-4aezA:
undetectable		 3jb2A-4aezA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4aez WD REPEAT-CONTAINING
PROTEIN SLP1
MITOTIC SPINDLE
CHECKPOINT COMPONENT
MAD3
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		3 / 3 ASN A 459
ASP A 173
ARG C  55
 None
 0.92A 3k13C-4aezA:
undetectable		 3k13C-4aezA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB509_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4aez MITOTIC SPINDLE
CHECKPOINT COMPONENT
MAD2
(Schizosaccharomy
ces
pombe) 		4 / 4 PHE B 151
THR B 150
LEU B  31
TYR B  37
 None
 1.31A 3pgyB-4aezB:
undetectable		 3pgyB-4aezB:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 4aez WD REPEAT-CONTAINING
PROTEIN SLP1
MITOTIC SPINDLE
CHECKPOINT COMPONENT
MAD3
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		3 / 3 GLU C  24
PHE A 411
GLN C  88
 None
 0.86A 3r55A-4aezC:
undetectable		 3r55A-4aezC:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4aez MITOTIC SPINDLE
CHECKPOINT COMPONENT
MAD2
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP B 158
LYS B 159
ASP B 160
 None
 0.77A 4a7tA-4aezB:
undetectable		 4a7tA-4aezB:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 4aez MITOTIC SPINDLE
CHECKPOINT COMPONENT
MAD2
(Schizosaccharomy
ces
pombe) 		4 / 8 VAL B  19
TYR B  25
ILE B 193
ILE B 128
 None
 0.99A 4afgD-4aezB:
undetectable
4afgE-4aezB:
undetectable		 4afgD-4aezB:
20.48
4afgE-4aezB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4aez WD REPEAT-CONTAINING
PROTEIN SLP1
(Schizosaccharomy
ces
pombe) 		5 / 10 VAL A 266
ALA A 225
SER A 270
LEU A 276
VAL A 245
 None
 1.46A 4kyaC-4aezA:
undetectable		 4kyaC-4aezA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 4aez WD REPEAT-CONTAINING
PROTEIN SLP1
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A 186
LEU A 444
THR A 408
VAL A 439
 None
 0.95A 4udaA-4aezA:
undetectable		 4udaA-4aezA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 4aez WD REPEAT-CONTAINING
PROTEIN SLP1
MITOTIC SPINDLE
CHECKPOINT COMPONENT
MAD3
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		4 / 5 GLY A 367
THR A 368
GLY A 410
GLU C  21
 None
 1.09A 4v20A-4aezA:
undetectable		 4v20A-4aezA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4aez MITOTIC SPINDLE
CHECKPOINT COMPONENT
MAD3
(Schizosaccharomy
ces
pombe) 		4 / 6 ARG C 121
ILE C 122
GLN C 125
ILE C 151
 None
 1.13A 4z4cA-4aezC:
undetectable		 4z4cA-4aezC:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 4aez WD REPEAT-CONTAINING
PROTEIN SLP1
(Schizosaccharomy
ces
pombe) 		5 / 12 LYS A 342
ALA A 382
THR A 386
THR A 364
LEU A 362
 None
 1.29A 4z7fC-4aezA:
undetectable		 4z7fC-4aezA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4aez WD REPEAT-CONTAINING
PROTEIN SLP1
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE A 411
ARG A 438
PRO A 412
THR A 394
 None
 1.27A 5ih0A-4aezA:
undetectable		 5ih0A-4aezA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4aez WD REPEAT-CONTAINING
PROTEIN SLP1
(Schizosaccharomy
ces
pombe) 		5 / 12 ASP A 325
ALA A 284
SER A 282
GLY A 309
LEU A 310
 None
 1.25A 5m54E-4aezA:
undetectable		 5m54E-4aezA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 4aez WD REPEAT-CONTAINING
PROTEIN SLP1
(Schizosaccharomy
ces
pombe) 		5 / 12 ASP A 180
ALA A 197
ARG A 265
GLY A 241
LEU A 240
 None
 1.19A 5m5cB-4aezA:
undetectable		 5m5cB-4aezA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4aez WD REPEAT-CONTAINING
PROTEIN SLP1
(Schizosaccharomy
ces
pombe) 		5 / 10 ASP A 325
ALA A 284
SER A 282
GLY A 309
LEU A 310
 None
 1.23A 5m5cE-4aezA:
undetectable		 5m5cE-4aezA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4aez WD REPEAT-CONTAINING
PROTEIN SLP1
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP A 388
SER A 417
SER A 407
 None
 0.74A 6mxtA-4aezA:
undetectable		 6mxtA-4aezA:
23.24