SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4af1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 4af1 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1
(Halobacterium
salinarum) 		5 / 12 LEU A 312
GLY A 404
GLY A 405
THR A 308
LEU A 320
 None
 1.07A 1liiA-4af1A:
undetectable		 1liiA-4af1A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 4af1 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1
(Halobacterium
salinarum) 		3 / 3 ASP A 329
ARG A 347
ASP A 373
 None
 0.93A 1vptA-4af1A:
undetectable		 1vptA-4af1A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 4af1 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1
(Halobacterium
salinarum) 		4 / 6 ASP A  86
ILE A  45
LEU A  82
GLU A 116
 None
 1.02A 2ya7B-4af1A:
undetectable		 2ya7B-4af1A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 4af1 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1
(Halobacterium
salinarum) 		4 / 6 ASP A  86
ILE A  45
LEU A  82
GLU A 116
 None
 1.01A 2ya7D-4af1A:
undetectable		 2ya7D-4af1A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4af1 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1
(Halobacterium
salinarum) 		3 / 3 GLY A 106
ASP A 102
SER A  30
 None
 0.51A 3brfA-4af1A:
undetectable		 3brfA-4af1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 4af1 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1
(Halobacterium
salinarum) 		4 / 4 GLY A 106
ASP A 102
GLY A  31
THR A  69
 None
 1.08A 3k4vC-4af1A:
undetectable		 3k4vC-4af1A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 4af1 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1
(Halobacterium
salinarum) 		4 / 4 GLY A 149
TYR A 148
GLY A 224
ASP A 223
 None
 1.18A 3kl3A-4af1A:
undetectable		 3kl3A-4af1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4af1 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1
(Halobacterium
salinarum) 		4 / 8 SER A 413
GLY A 408
MET A 314
GLY A 315
 None
 0.69A 4fo4B-4af1A:
undetectable		 4fo4B-4af1A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 4af1 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1
(Halobacterium
salinarum) 		3 / 3 ASP A 329
ARG A 347
ASP A 373
 None
 0.68A 4fp9D-4af1A:
undetectable		 4fp9D-4af1A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4af1 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1
(Halobacterium
salinarum) 		3 / 3 ASP A 329
ARG A 347
ASP A 373
 None
 0.87A 4fzvA-4af1A:
undetectable		 4fzvA-4af1A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4af1 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1
(Halobacterium
salinarum) 		5 / 12 GLY A  29
PHE A  97
GLY A  99
ALA A 100
ILE A  37
 None
 1.00A 4rtmA-4af1A:
undetectable		 4rtmA-4af1A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4af1 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1
(Halobacterium
salinarum) 		5 / 12 LEU A 265
VAL A 160
ALA A 275
LEU A 247
LEU A 243
 None
 0.97A 5tudA-4af1A:
2.5		 5tudA-4af1A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 4af1 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1
(Halobacterium
salinarum) 		5 / 12 GLU A 306
LEU A 399
LEU A 320
ILE A 372
GLU A 328
 None
 1.15A 5v0vA-4af1A:
undetectable		 5v0vA-4af1A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4af1 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1
(Halobacterium
salinarum) 		4 / 5 MET A 288
TYR A 406
GLY A 405
GLY A 404
 None
 1.18A 5x7pA-4af1A:
undetectable		 5x7pA-4af1A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 4af1 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1
(Halobacterium
salinarum) 		4 / 7 LEU A 265
PHE A 237
GLY A 209
GLY A 161
 None
 0.76A 6eu9D-4af1A:
undetectable		 6eu9D-4af1A:
12.08