SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4af2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 4af2 THIOL PEROXIDASE
(Escherichia
coli) 		4 / 8 PRO A  54
THR A  58
LEU A 127
ARG A 133
 None
 0.83A 1h4oG-4af2A:
18.7		 1h4oG-4af2A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1URM_A_BEZA201_0
(PEROXIREDOXIN 5)		 4af2 THIOL PEROXIDASE
(Escherichia
coli) 		5 / 9 PRO A  54
THR A  58
SER A  61
LEU A 127
ARG A 133
 None
 0.93A 1urmA-4af2A:
18.7		 1urmA-4af2A:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4af2 THIOL PEROXIDASE
(Escherichia
coli) 		4 / 7 THR A  58
VAL A  60
SER A  61
ARG A 133
 None
 0.27A 2v2gA-4af2A:
16.7
2v2gB-4af2A:
16.6		 2v2gA-4af2A:
24.90
2v2gB-4af2A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4af2 THIOL PEROXIDASE
(Escherichia
coli) 		4 / 7 THR A  58
VAL A  60
SER A  61
ARG A 133
 None
 0.31A 2v2gA-4af2A:
16.7
2v2gB-4af2A:
16.6		 2v2gA-4af2A:
24.90
2v2gB-4af2A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4af2 THIOL PEROXIDASE
(Escherichia
coli) 		4 / 7 THR A  58
VAL A  60
SER A  61
ARG A 133
 None
 0.28A 2v2gC-4af2A:
16.6
2v2gD-4af2A:
16.7		 2v2gC-4af2A:
24.90
2v2gD-4af2A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4af2 THIOL PEROXIDASE
(Escherichia
coli) 		4 / 7 THR A  58
VAL A  60
SER A  61
ARG A 133
 None
 0.29A 2v2gC-4af2A:
16.6
2v2gD-4af2A:
16.7		 2v2gC-4af2A:
24.90
2v2gD-4af2A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4af2 THIOL PEROXIDASE
(Escherichia
coli) 		4 / 8 THR A  58
VAL A  60
SER A  61
ARG A 133
 None
 0.23A 2v32A-4af2A:
16.5
2v32B-4af2A:
16.7		 2v32A-4af2A:
24.90
2v32B-4af2A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4af2 THIOL PEROXIDASE
(Escherichia
coli) 		4 / 8 THR A  58
VAL A  60
SER A  61
ARG A 133
 None
 0.29A 2v32A-4af2A:
16.5
2v32B-4af2A:
16.7		 2v32A-4af2A:
24.90
2v32B-4af2A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4af2 THIOL PEROXIDASE
(Escherichia
coli) 		5 / 8 PRO A  54
THR A  58
VAL A  60
SER A  61
ARG A 133
 None
 0.35A 2v32C-4af2A:
16.7
2v32D-4af2A:
18.1		 2v32C-4af2A:
24.90
2v32D-4af2A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4af2 THIOL PEROXIDASE
(Escherichia
coli) 		4 / 8 THR A  58
VAL A  60
SER A  61
ARG A 133
 None
 0.28A 2v32C-4af2A:
16.7
2v32D-4af2A:
18.1		 2v32C-4af2A:
24.90
2v32D-4af2A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_A_BEZA1222_0
(PEROXIREDOXIN 6.)		 4af2 THIOL PEROXIDASE
(Escherichia
coli) 		5 / 9 PRO A  54
THR A  58
VAL A  60
SER A  61
ARG A 133
 None
 0.41A 2v41A-4af2A:
16.2
2v41B-4af2A:
16.7		 2v41A-4af2A:
24.90
2v41B-4af2A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_B_BEZB1222_0
(PEROXIREDOXIN 6.)		 4af2 THIOL PEROXIDASE
(Escherichia
coli) 		5 / 9 PRO A  54
THR A  58
VAL A  60
SER A  61
ARG A 133
 None
 0.42A 2v41A-4af2A:
16.7
2v41B-4af2A:
16.7		 2v41A-4af2A:
24.90
2v41B-4af2A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 4af2 THIOL PEROXIDASE
(Escherichia
coli) 		5 / 8 PRO A  54
THR A  58
VAL A  60
SER A  61
ARG A 133
 None
 0.44A 2v41C-4af2A:
18.0
2v41D-4af2A:
18.2		 2v41C-4af2A:
24.90
2v41D-4af2A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 4af2 THIOL PEROXIDASE
(Escherichia
coli) 		5 / 8 PRO A  54
THR A  58
VAL A  60
SER A  61
ARG A 133
 None
 0.40A 2v41C-4af2A:
18.0
2v41D-4af2A:
18.2		 2v41C-4af2A:
24.90
2v41D-4af2A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 4af2 THIOL PEROXIDASE
(Escherichia
coli) 		4 / 7 THR A  58
VAL A  60
SER A  61
ARG A 133
 None
 0.39A 2v41E-4af2A:
16.6
2v41F-4af2A:
16.5		 2v41E-4af2A:
24.90
2v41F-4af2A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 4af2 THIOL PEROXIDASE
(Escherichia
coli) 		4 / 7 THR A  58
VAL A  60
SER A  61
ARG A 133
 None
 0.38A 2v41E-4af2A:
16.6
2v41F-4af2A:
16.5		 2v41E-4af2A:
24.90
2v41F-4af2A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 4af2 THIOL PEROXIDASE
(Escherichia
coli) 		4 / 8 THR A  58
VAL A  60
SER A  61
ARG A 133
 None
 0.36A 2v41G-4af2A:
16.8
2v41H-4af2A:
16.7		 2v41G-4af2A:
24.90
2v41H-4af2A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 4af2 THIOL PEROXIDASE
(Escherichia
coli) 		5 / 8 PRO A  54
THR A  58
VAL A  60
SER A  61
ARG A 133
 None
 0.41A 2v41G-4af2A:
16.7
2v41H-4af2A:
16.7		 2v41G-4af2A:
24.90
2v41H-4af2A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CB8_A_SAMA501_0
(PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME)		 4af2 THIOL PEROXIDASE
(Escherichia
coli) 		5 / 12 ASN A  51
SER A  61
VAL A 120
LEU A 115
TYR A 118
 None
 1.36A 3cb8A-4af2A:
undetectable		 3cb8A-4af2A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 4af2 THIOL PEROXIDASE
(Escherichia
coli) 		5 / 11 VAL A   5
ALA A 134
THR A 154
THR A 155
PRO A 157
 None
 1.13A 3mdzA-4af2A:
undetectable		 3mdzA-4af2A:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4af2 THIOL PEROXIDASE
(Escherichia
coli) 		3 / 3 VAL A 150
VAL A  60
SER A  64
 None
 0.62A 3n8xB-4af2A:
undetectable		 3n8xB-4af2A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4af2 THIOL PEROXIDASE
(Escherichia
coli) 		3 / 3 THR A  29
VAL A  31
GLU A 113
 None
 0.77A 3v4tA-4af2A:
undetectable
3v4tD-4af2A:
undetectable		 3v4tA-4af2A:
21.24
3v4tD-4af2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4af2 THIOL PEROXIDASE
(Escherichia
coli) 		4 / 6 THR A 155
GLN A 148
THR A  58
ASN A  51
 None
 1.28A 4pfjB-4af2A:
2.3		 4pfjB-4af2A:
21.00